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Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine
Zhijin Fan, Cheng Jiang, Yichao Wang, Kaiyuan Wang, Jade Marsh, Da Zhang, Xin Chen and Liming Nie
Nanoscale Horiz., 2022, 7, 682
DOI: 10.1039/D2NH00070A

Recent advances in carbohydrate-based gelators
Rajdeep Tyagi, Kavita Singh, Nitin Srivastava and Ram Sagar
Mater. Adv., 2023, 4, 3929
DOI: 10.1039/D3MA00321C

Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy
Meiyu Wang, Bin Gao, Xiaoyu Wang, Wenzhong Li and Yakai Feng
Biomater. Sci., 2022, 10, 1883
DOI: 10.1039/D2BM00067A

Stimuli-responsive polymers for sensing and actuation
Liang Hu, Qiang Zhang, Xue Li and Michael J. Serpe
Mater. Horiz., 2019, 6, 1774
DOI: 10.1039/C9MH00490D

A tumour mRNA-triggered nanoassembly for enhanced fluorescence imaging-guided photodynamic therapy
Mei-Hao Xiang, Na Li, Jin-Wen Liu, Ru-Qin Yu and Jian-Hui Jiang
Nanoscale, 2020, 12, 8727
DOI: 10.1039/D0NR00941E

Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release
Yang Li, Yimin Niu, Jianhua Zhu, Cuicui Gao, Qunwei Xu, Zhiyu He, Dawei Chen, Ming Xu and Yang Liu
Nanoscale, 2020, 12, 2673
DOI: 10.1039/C9NR08558K

Ultrasound responsive erythrocyte membrane-derived hybrid nanovesicles with controlled drug release for tumor therapy
Dongdong Wang, Yuzhu Yao, Yi Xiao, Xue Chen, Jun Hu and Xiangliang Yang
Nanoscale, 2021, 13, 9945
DOI: 10.1039/D1NR01916C

Gold nanoparticle layer: a versatile nanostructured platform for biomedical applications
Jingxian Wu, Yangcui Qu, Qian Yu and Hong Chen
Mater. Chem. Front., 2018, 2, 2175
DOI: 10.1039/C8QM00449H

Trigger-responsive engineered-nanocarriers and image-guided theranostics for rheumatoid arthritis
Nadim Ahamad, Ameya Prabhakar, Sourabh Mehta, Ekta Singh, Eshant Bhatia, Shivam Sharma and Rinti Banerjee
Nanoscale, 2020, 12, 12673
DOI: 10.1039/D0NR01648A

Ultrasound-degradable serum albumin nanoplatform forin situcontrolled drug release
Jianjun Du, Yu Zhang, Haoying Ge, Chao Shi, Saran Long, Wen Sun, Jiangli Fan and Xiaojun Peng
Chem. Commun., 2020, 56, 7503
DOI: 10.1039/D0CC01937B

Smart polymers: key to targeted therapeutic interventions
Divyanshi Thakkar, Rhythm Sehgal, A. K. Narula and Deepa Deswal
Chem. Commun., 2025, 61, 192
DOI: 10.1039/D4CC05098C

Redox-sensitive dimeric paclitaxel choline phosphate nanoliposomes for improved anticancer efficacy
Jinzhong Hu, Zhiguo Gao, Kai Sun, Min Liu, Zining Wang, Jiaying Yu, Wanying Wei, Xiaofan He, Senlin Wang, Yaojia Li and Baiwang Sun
New J. Chem., 2023, 47, 16884
DOI: 10.1039/D3NJ02921B

Assessing the range of enzymatic and oxidative tunability for biosensor design
Hattie C. Schunk, Derek S. Hernandez, Mariah J. Austin, Kabir S. Dhada, Adrianne M. Rosales and Laura J. Suggs
J. Mater. Chem. B, 2020, 8, 3460
DOI: 10.1039/C9TB02666E

Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions
Hikaru Fujita, Yunlong Zhang, Zhiyuan Wu and Jonathan S. Lindsey
New J. Chem., 2020, 44, 3856
DOI: 10.1039/C9NJ06187H

Indoxyl-glucosides bearing tethers for enzymatically triggered cross-linking
Daisuke Sato, Zhiyuan Wu, Jinghuai Dou, Juno Son and Jonathan S. Lindsey
New J. Chem., 2023, 47, 8223
DOI: 10.1039/D2NJ06267D

Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers
Ying Yuan, Tianqi Nie, Yifen Fang, Xinru You, Hai Huang and Jun Wu
J. Mater. Chem. B, 2022, 10, 2077
DOI: 10.1039/D1TB02683F

Stimulus-responsive self-assembled prodrugs in cancer therapy
Xiao Dong, Rajeev K. Brahma, Chao Fang and Shao Q. Yao
Chem. Sci., 2022, 13, 4239
DOI: 10.1039/D2SC01003H

Expanding the scope of self-assembled supramolecular biosensors: a highly selective and sensitive enzyme-responsive AIE-based fluorescent biosensor for trypsin detection and inhibitor screening
Jasvir Kaur, Harshad A. Mirgane, Vrushali S. Patil, Geetika M. Ahlawat, Sheshanath V. Bhosale and Prabhat K. Singh
J. Mater. Chem. B, 2024, 12, 3786
DOI: 10.1039/D4TB00264D

Hydrophobicity as a tool for programming sequential mesophase transitions of enzyme-responsive polymeric amphiphiles
Shahar Tevet and Roey J. Amir
J. Mater. Chem. B, 2024, 12, 11685
DOI: 10.1039/D4TB01587H

Engineering therapeutic scaffolds: integrating drug delivery with tissue regeneration
Melika Mansouri Moghaddam, Mohamad Sadegh Aghajanzadeh and Rana Imani
J. Mater. Chem. B, 2025, 13, 10780
DOI: 10.1039/D5TB01338K

Tumor microenvironment-activatable boolean logic supramolecular nanotheranostics based on a pillar[6]arene for tumor hypoxia imaging and multimodal synergistic therapy
Xin Liu, Chi Meng, Guiqing Ji, Ji Liu, Peng Zhu, Jianqiang Qian, Shun-Xing Zhu, Yanan Zhang and Yong Ling
Mater. Chem. Front., 2021, 5, 5846
DOI: 10.1039/D1QM00411E

mRNA-activated DNAzyme nanoprobe for tumor cell precise imaging and gene therapy
Mingzhu Fan, Huakui Huang, Yang Xu, Shulong Wang, Shengyu Chen, Zhihui Luo and Jiayao Xu
Anal. Methods, 2023, 15, 4114
DOI: 10.1039/D3AY00937H

Advanced disease therapeutics using engineered living drug delivery systems
Narsimha Mamidi, Fátima Franco De Silva and Amin Orash Mahmoudsalehi
Nanoscale, 2025, 17, 7673
DOI: 10.1039/D4NR05298F

Ultrasound nanomedicine and materdicine
Zeyu Wang, Xue Wang, Meiqi Chang, Jia Guo and Yu Chen
J. Mater. Chem. B, 2023, 11, 5350
DOI: 10.1039/D2TB02640F

Stimulus-cleavable chemistry in the field of controlled drug delivery
Yufei Xue, Hua Bai, Bo Peng, Bin Fang, Jonathan Baell, Lin Li, Wei Huang and Nicolas Hans Voelcker
Chem. Soc. Rev., 2021, 50, 4872
DOI: 10.1039/D0CS01061H

Recent developments in selenium-containing polymeric micelles: prospective stimuli, drug-release behaviors, and intrinsic anticancer activity
Yihenew Simegniew Birhan and Hsieh-Chih Tsai
J. Mater. Chem. B, 2021, 9, 6770
DOI: 10.1039/D1TB01253C

Micromotor-assisted highly efficient Fenton catalysis by a laccase/Fe-BTC-NiFe2O4 nanozyme hybrid with a 3D hierarchical structure
Jie Yang, Jia Li, Dickon H. L. Ng, Ping Yang, Wenning Yang and Yong Liu
Environ. Sci.: Nano, 2020, 7, 2573
DOI: 10.1039/C9EN01443H

Enzyme-responsive targeted nanomedicines: a novel strategy for cancer therapy
Mingtang Zeng, Zhongzhen Yang, Liuxuan Yang, Xueyan Wang, Yao Wang, Tao Chen, Xi Yin and Fengbo Wu
J. Mater. Chem. B, 2026, 14, 3661
DOI: 10.1039/D6TB00076B

Controlling the semi-permeability of protein nanocapsules influences the cellular response to macromolecular payloads
Marina Machtakova, Sebastian Wirsching, Stephan Gehring, Katharina Landfester and Héloïse Thérien-Aubin
J. Mater. Chem. B, 2021, 9, 8389
DOI: 10.1039/D1TB01368H

One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors
Dongliang Yang, Fei Chen, Shili He, Haifeng Shen, Yanling Hu, Ning Feng, Siyu Wang, Lixing Weng, Zhimin Luo and Lianhui Wang
New J. Chem., 2019, 43, 13256
DOI: 10.1039/C9NJ03045J

A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly
Jie Gao, Huijuan Yu, Fang-Yuan Chen, Xin-Yue Hu, Yuefei Wang and Dong-Sheng Guo
Chem. Commun., 2019, 55, 14387
DOI: 10.1039/C9CC08199B

Nanocarrier strategies for deep tumour penetration
Jinbo Zhang, Guanjiang Wu and Valentin A. Bobrin
RSC Appl. Polym., 2025, 3, 1403
DOI: 10.1039/D5LP00154D

Biosignal-responsive polymer nanorods that specifically recognize hydrogen polysulfide (H2Sn) from reactive sulfur species
Xi Liu, Wei Sang, Kunbing Ouyang and Qiang Yan
Polym. Chem., 2020, 11, 2781
DOI: 10.1039/D0PY00360C

Single-atom nanozymes: classification, regulation strategy, and safety concerns
Jiping Han, Yaohua Gu, Changyi Yang, Lingchen Meng, Runmei Ding, Yifan Wang, Keren Shi and Huiqin Yao
J. Mater. Chem. B, 2023, 11, 9840
DOI: 10.1039/D3TB01644G

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection
Yuanbo Pan, Wei Tang, Wenpei Fan, Jianmin Zhang and Xiaoyuan Chen
Chem. Soc. Rev., 2022, 51, 9759
DOI: 10.1039/D1CS01145F

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
Vu Thanh Cong, Jacinta L. Houng, Maria Kavallaris, Xin Chen, Richard D. Tilley and J. Justin Gooding
Chem. Soc. Rev., 2022, 51, 7531
DOI: 10.1039/D1CS00707F

Current status and prospects of MOFs loaded with H2O2-related substances for ferroptosis therapy
Yu Deng, Sida Huang, Guanming Jiang, Luyi Zhou, Alireza Nezamzadeh-Ejhieh, Jianqiang Liu and Zhikun Zhou
RSC Med. Chem., 2024, 15, 2996
DOI: 10.1039/D4MD00261J

ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy
Jinghua Li, Yun Liu, Xiaonan Li, Gaofeng Liang, Changshun Ruan and Kaiyong Cai
Nanoscale Horiz., 2020, 5, 350
DOI: 10.1039/C9NH00490D

Enzymatically triggered chromogenic cross-linking agents under physiological conditions
Hikaru Fujita, Jinghuai Dou, Nobuyuki Matsumoto, Zhiyuan Wu and Jonathan S. Lindsey
New J. Chem., 2020, 44, 719
DOI: 10.1039/C9NJ04126E

Bioorthogonal chemistry-based prodrug strategies for enhanced biosafety in tumor treatments: current progress and challenges
Yongchao Yao, Ying Chen, Chang Zhou, Quanzhi Zhang, Xun He, Kai Dong, Chengli Yang, Bingyang Chu and Zhiyong Qian
J. Mater. Chem. B, 2024, 12, 10818
DOI: 10.1039/D4TB01413H

Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy
Haitao Sun, Meixia Feng, Siyu Chen, Ruizhi Wang, Yu Luo, Bo Yin, Jingchao Li and Xiaolin Wang
J. Mater. Chem. B, 2020, 8, 7149
DOI: 10.1039/D0TB01437K

Chemical probes for enzyme imaging: challenges in design, synthesis and biomedical applications
Julia Nguyen, Maksymilian Zabijak and Marcin Poręba
Chem. Sci., 2025, 16, 21174
DOI: 10.1039/D5SC05683G

Layered double hydroxide-based nanomaterials for biomedical applications
Tingting Hu, Zi Gu, Gareth R. Williams, Margarita Strimaite, Jiajia Zha, Zhan Zhou, Xingcai Zhang, Chaoliang Tan and Ruizheng Liang
Chem. Soc. Rev., 2022, 51, 6126
DOI: 10.1039/D2CS00236A

Stimuli responsive dynamic transformations in supramolecular gels
Santanu Panja and Dave J. Adams
Chem. Soc. Rev., 2021, 50, 5165
DOI: 10.1039/D0CS01166E

Innovative strategies for enhanced tumor photodynamic therapy
Guo Li, Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin, Xiaobo Zhou and Li Wu
J. Mater. Chem. B, 2021, 9, 7347
DOI: 10.1039/D1TB01466H

Recent advances in activatable NIR-II organic fluorophores for biomedical applications
Yanzi Xu, Peijuan Zhang, Anran Gao, Ruohan Xu, Zhi Wang, Qifei Shen, Zhiqin Zhao, Lingjie Meng and Dongfeng Dang
Mater. Chem. Front., 2023, 7, 828
DOI: 10.1039/D2QM01120D

Enzymatically Activatable Polymers for Disease Diagnosis and Treatment
Bin Ma, Jiahao Shi, Yuhe Zhang, Zhili Li, Haiyang Yong, Ya‐Nan Zhou, Shuai Liu, Sigen A and Dezhong Zhou
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202306358

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors
Yanan Li, Ting Mei, Shupeng Han, Tao Han, Yongbing Sun, Hui Zhang and Feifei An
Chinese Chemical Letters, 2020, 31, 3027
DOI: 10.1016/j.cclet.2020.05.027

Versatile Peptide-Based Nanosystems for Photodynamic Therapy
Qiuyan Li, Ruiqi Ming, Lili Huang and Ruoyu Zhang
Pharmaceutics, 2024, 16, 218
DOI: 10.3390/pharmaceutics16020218

In situ formulation of biomaterials for disease therapy: Recent advances in peptide assembly strategies
Wenmin Xiong, Na Song, Xiaowei Mo, Zeyu Zhang, Jinyan Song, Yushi Wang, Junyu Li and Zhilin Yu
Coordination Chemistry Reviews, 2025, 523, 216251
DOI: 10.1016/j.ccr.2024.216251

Nanofibers in Organelles: From Structure Design to Biomedical Applications
Jing‐Jing Hu, Niya Lin, Yunfan Zhang, Fan Xia and Xiaoding Lou
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202313139

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss
Shi Cheng, Kong‐Huai Wang, Lu Zhou, Zhi‐Jun Sun and Lu Zhang
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202304021

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation
Petr Rozhin, Jada Abdel Monem Gamal, Silvia Giordani and Silvia Marchesan
Materials, 2022, 15, 1037
DOI: 10.3390/ma15031037

Revolutionizing drug delivery: The power of stimulus-responsive nanoscale systems
Shumeng Hu, Runan Zhao, Yue Shen and Bo Lyu
Chemical Engineering Journal, 2024, 496, 154265
DOI: 10.1016/j.cej.2024.154265

Enzyme-triggered smart antimicrobial drug release systems against bacterial infections
Qian Zhou, Zhangyong Si, Kun Wang, Kunpeng Li, Weilin Hong, Yuezhou Zhang and Peng Li
Journal of Controlled Release, 2022, 352, 507
DOI: 10.1016/j.jconrel.2022.10.038

Transformable vesicles for cancer immunotherapy
Shuang Wang, Xiaoming Hu, Wei Wei and Guanghui Ma
Advanced Drug Delivery Reviews, 2021, 179, 113905
DOI: 10.1016/j.addr.2021.113905

Red-Light-Responsive Polypeptoid Nanoassemblies Containing a Ruthenium(II) Polypyridyl Complex with Synergistically Enhanced Drug Release and ROS Generation for Anticancer Phototherapy
Yandong Ma, Zhihua Zhang, Fan Sun, Pierre Mesdom, Xin Ji, Pierre Burckel, Gilles Gasser and Min-Hui Li
Biomacromolecules, 2023, 24, 5940
DOI: 10.1021/acs.biomac.3c00949

Combretastatin A4 Nanodrug‐Induced MMP9 Amplification Boosts Tumor‐Selective Release of Doxorubicin Prodrug
Jian Jiang, Na Shen, Tianyuan Ci, Zhaohui Tang, Zhen Gu, Gao Li and Xuesi Chen
Advanced Materials, 2019, 31
DOI: 10.1002/adma.201904278

Pd@Pt-GOx/HA as a Novel Enzymatic Cascade Nanoreactor for High-Efficiency Starving-Enhanced Chemodynamic Cancer Therapy
Jiang Ming, Tianbao Zhu, Wangheng Yang, Yiran Shi, Doudou Huang, Jingchao Li, Sijin Xiang, Jingjuan Wang, Xiaolan Chen and Nanfeng Zheng
ACS Appl. Mater. Interfaces, 2020, 12, 51249
DOI: 10.1021/acsami.0c15211

Activatable dual-functional molecular agents for imaging-guided cancer therapy
Peng Zhang, Yaowei Zhu, Chunsheng Xiao and Xuesi Chen
Advanced Drug Delivery Reviews, 2023, 195, 114725
DOI: 10.1016/j.addr.2023.114725

Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis
Tomoaki Kurosaki, Hiroki Kanda, Junya Hashizume, Kayoko Sato, Hitomi Harasawa, Tadahiro Nakamura, Hitoshi Sasaki and Yukinobu Kodama
Pharmaceutics, 2021, 13, 1983
DOI: 10.3390/pharmaceutics13111983

Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging
Hang He, Song Meng, Haimin Li, Qingyuan Yang, Ziqiang Xu, Xueqin Chen, Zhengguang Sun, Bingbing Jiang and Cao Li
Microchim Acta, 2021, 188
DOI: 10.1007/s00604-021-04810-4

Smart Materials and Devices for Enhanced Delivery of Extracellular Vesicles
Yang You, Mengrui Liu, Na Yan, Dashuai Zhu, Xiao Cheng, Yilan Hu, Yuan Li, Zhen Qin, Zhixin Zhu and Ke Cheng
Advanced Materials, 2025, 37
DOI: 10.1002/adma.202501081

Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine
Peng He, Guozheng Yang, Danzhu Zhu, Hao Kong, Yendry Regina Corrales-Ureña, Lucio Colombi Ciacchi and Gang Wei
J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01691-4

Cellulose Nanocrystal-Based Sulfatase-Responsive Hydrogel for Sustained Celecoxib Release in Ulcerative Colitis Therapy
Panalee Pomseethong, Mydhili Govindarasu, Garima Sharma, Yuyuan Guo, Jomon George Joy, Songrae Kim, Seung-Hwan Lee and Jin-Chul Kim
Biomater Res, 2026, 30
DOI: 10.34133/bmr.0304

100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery
Huanli Sun and Zhiyuan Zhong
ACS Macro Lett., 2020, 9, 1292
DOI: 10.1021/acsmacrolett.0c00488

Core–Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging
Xianlei Li, Massimo Bottini, Luyao Zhang, Shuai Zhang, Jing Chen, Tingbin Zhang, Lu Liu, Nicola Rosato, Xibo Ma, Xinghua Shi, Yan Wu, Weisheng Guo and Xing-Jie Liang
ACS Nano, 2019, 13, 176
DOI: 10.1021/acsnano.8b05136

Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
Pengxuan Zhao, Youbin Deng, Guangya Xiang and Yani Liu
IJN, 2021, Volume 16, 4615
DOI: 10.2147/IJN.S307885

Targeted Delivery of Doxorubicin to Hepatoma Cells by Lactobionic Acid-Decorated Dual Redox-Responsive Polyethylene Glycol-Doxorubicin Nanoparticles
Yang Fu, Chaohui Ji, Zhiheng Ma, Defeng Xu and Hang Hu
Int. J. Nanosci., 2023, 22
DOI: 10.1142/S0219581X23500199

Stimuli-Induced Architectural Transition as a Tool for Controlling the Enzymatic Degradability of Polymeric Micelles
Gadi Slor, Shahar Tevet and Roey J. Amir
ACS Polym. Au, 2022, 2, 380
DOI: 10.1021/acspolymersau.2c00023

NIR-activated self-sensitized polymeric micelles for enhanced cancer chemo-photothermal therapy
Lijun Yang, Xiaoxue Hou, Yumin Zhang, Dianyu Wang, Jinjian Liu, Fan Huang and Jianfeng Liu
Journal of Controlled Release, 2021, 339, 114
DOI: 10.1016/j.jconrel.2021.09.017

Time and Space Dual‐Blockade Strategy for Highly Invasive Nature of Triple‐Negative Breast Cancer in Enhanced Sonodynamic Therapy Based on Fe‐MOF Nanoplatforms
Cheng Cao, Yi Lu, Xinni Pan, Yuwan Lin, Shanshan Fan, Jiaqi Niu, Shujing Lin, Haisong Tan, You Wang, Shengsheng Cui and Yanlei Liu
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202304249

Enzyme immobilization using two processing methods onto silica core-shell particles
Milan P. Nikolić, Vladimir B. Pavlović, Slobodanka Stanojević-Nikolić and Vladimir V. Srdić
Boletín de la Sociedad Española de Cerámica y Vidrio, 2021, 60, 243
DOI: 10.1016/j.bsecv.2020.03.004

Site-specific adaptive nanovesicles for oral insulin delivery
Bozhang Xia, Fengfei Xu, Junge Chen, Shaobo Shan, Jiuheng Shen, Yuxuan Zhang, Jinjin Wang, Ziran Zhou, Weilun Sun, Yaru Jia, Ya-Li Zhang, Jie Zhong, Gang Zhang, Yichen Wan, Zhongbo Hu, Wenlin An, Yubo Fan, Massimo Bottini, Jinqiang Wang and Xing-Jie Liang
Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.ady6386

Enzyme Tagged Poly (Acrylic Acid)‐grafted‐Nanoparticles: A Unique Strategy to Improve Stability and Activity of Enzyme
Somdatta Rudra, Sounak Chatterjee and Tushar Jana
Macro Chemistry & Physics, 2026, 227
DOI: 10.1002/macp.202500457

Recent trends and development in targeted delivery of therapeutics through enzyme responsive intelligent nanoplatform
Sundus Irshad, Bazla Siddiqui, Asim. ur.Rehman, Rai Khalid Farooq and Naveed Ahmed
International Journal of Polymeric Materials and Polymeric Biomaterials, 2022, 71, 403
DOI: 10.1080/00914037.2020.1848829

Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications
Chaeyoung Lim and Whitney C. Blocher McTigue
ACS Biomater. Sci. Eng., 2024, 10, 6766
DOI: 10.1021/acsbiomaterials.4c01105

Stimuli‐Responsive Pickering Emulsions Regulated via Polymerization‐Induced Self‐Assembly Nanoparticles
Shuo Zhou, Min Zeng, Yanlin Liu, Xiaofeng Sui and Jinying Yuan
Macromol. Rapid Commun., 2022, 43
DOI: 10.1002/marc.202200010

A versatile biocatalytic nano-platform based on Fe3O4-filled and zirconia shrunk holey carbon nanotubes
Jie Shi, Shan Zhang, Qianchun Deng, Ya Li, Zhigang Geng, Lei Zheng and Bo Tang
Chemical Engineering Journal, 2020, 402, 125737
DOI: 10.1016/j.cej.2020.125737

Self-Assembly of Intelligent Nanoplatform for Endogenous H2S-Triggered Multimodal Cascade Therapy of Colon Cancer
Lan Yang, Yupeng Zhu, Liuqing Liang, Chenhui Wang, Xinghai Ning and Xuli Feng
Nano Lett., 2022, 22, 4207
DOI: 10.1021/acs.nanolett.2c01131

Bioresponsive drug delivery systems for the treatment of inflammatory diseases
Yin Dou, Chenwen Li, Lanlan Li, Jiawei Guo and Jianxiang Zhang
Journal of Controlled Release, 2020, 327, 641
DOI: 10.1016/j.jconrel.2020.09.008

Cancer Nanomedicines Based on Synthetic Polypeptides
Huanli Sun, Xiaolei Gu, Qiang Zhang, Hao Xu, Zhiyuan Zhong and Chao Deng
Biomacromolecules, 2019, 20, 4299
DOI: 10.1021/acs.biomac.9b01291

Lipid Drug Conjugates in Pharmaceutical Formulations and Drug Delivery Systems
Chitrali Talele, Dipali Talele, Niyati Shah, Mamta Kumari, Piyushkumar Sadhu and Chintan Aundhia
DDL, 2025, 15, 1
DOI: 10.2174/0122103031304145240805092718

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
Zhong-Jian Chen, Si-Cong Yang, Xue-Liang Liu, Yuhao Gao, Xiao Dong, Xing Lai, Mao-Hua Zhu, Hai-Yi Feng, Xin-Di Zhu, Qin Lu, Mei Zhao, Hong-Zhuan Chen, Jonathan F. Lovell and Chao Fang
Nano Lett., 2020, 20, 4177
DOI: 10.1021/acs.nanolett.0c00495

Recent advances in hydrogel-based drug delivery systems for enhanced cancer therapy: A review
Fatemeh Davodabadi, Saman Sargazi and Francesco Baino
Materials Today Communications, 2025, 48, 113615
DOI: 10.1016/j.mtcomm.2025.113615

Tumor‐Targeted Catalytic Immunotherapy
En‐Li Yang, Wu‐Yin Wang, Ying‐Qi Liu, Hong Yi, Aiwen Lei and Zhi‐Jun Sun
Advanced Materials, 2025, 37
DOI: 10.1002/adma.202413210

Navigating tumor microenvironment with TME-responsive nanocarriers: Strategies for targeted drug delivery in solid tumor
Nandkishore Rajankar, Ankaj Kumar and Arvind Gulbake
Journal of Drug Delivery Science and Technology, 2025, 110, 107050
DOI: 10.1016/j.jddst.2025.107050

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Jinglin Wang, Haozhen Ren and Yuanjin Zhao
Nano-Micro Lett., 2023, 15
DOI: 10.1007/s40820-023-01018-4

Stimulus-responsive liposomes for biomedical applications
Antonia I. Antoniou, Sabrina Giofrè, Pierfausto Seneci, Daniele Passarella and Sara Pellegrino
Drug Discovery Today, 2021, 26, 1794
DOI: 10.1016/j.drudis.2021.05.010

Smart Nanoparticles for Chemo-Based Combinational Therapy
Binita Shrestha, Lijun Wang, Eric M. Brey, Gabriela Romero Uribe and Liang Tang
Pharmaceutics, 2021, 13, 853
DOI: 10.3390/pharmaceutics13060853

Biomarker-Guided Drug Delivery Systems and Oral Bioavailability Enhancement
Dang-Khoa Vo and Van-An Duong
Pharmaceuticals, 2026, 19, 454
DOI: 10.3390/ph19030454

Reactive Oxygen Species (ROS)-Based Nanomedicine
Bowen Yang, Yu Chen and Jianlin Shi
Chem. Rev., 2019, 119, 4881
DOI: 10.1021/acs.chemrev.8b00626

Computational assessment of thermostability in miRNA:CNT system using molecular dynamics simulations
Aysa Güvensoy-Morkoyun and Ozge Kurkcuoglu
Biochimica et Biophysica Acta (BBA) - General Subjects, 2021, 1865, 129808
DOI: 10.1016/j.bbagen.2020.129808

A Leucine Aminopeptidase-Activated Theranostic Prodrug for Cancer Diagnosis and Chemotherapy
Feiyi Wang, Sisi Hu, Qi Sun, Qiang Fei, Chao Ma, Cuifen Lu, Junqi Nie, Zuxing Chen, Jun Ren, Guo-Rong Chen, Guichun Yang, Xiao-Peng He and Tony D James
ACS Appl. Bio Mater., 2019, 2, 4904
DOI: 10.1021/acsabm.9b00655

Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment
Yaohua Wei, Xiao Weng, Yayun Wang and Weijing Yang
Biomacromolecules, 2024, 25, 4663
DOI: 10.1021/acs.biomac.4c00706

Exploring the Potential of Nanoparticles in the Treatment of Breast Cancer: Current Applications and Future Directions
Puja Patel, Vadanasundari Vedarethinam, Maame A. Korsah, Michael K. Danquah and Jaison Jeevanandam
Applied Sciences, 2024, 14, 1809
DOI: 10.3390/app14051809

Endogenous stimuli-responsive linkers in nanoliposomal systems for cancer drug targeting
Mahdi Faal Maleki, Arash Jafari, Elaheh Mirhadi, Anis Askarizadeh, Behrouz Golichenari, Farzin Hadizadeh, Seyed Mohammad Jalilzadeh Moghimi, Reihaneh Aryan, Mohammad Mashreghi and Mahmoud Reza Jaafari
International Journal of Pharmaceutics, 2019, 572, 118716
DOI: 10.1016/j.ijpharm.2019.118716

2-(Benzylthio)ethyl Glycidyl Ether: A Gateway to Redox-Responsive Polyethers
Ahyun Kim, Jinsu Baek and Byeong-Su Kim
Macromolecules, 2024, 57, 8544
DOI: 10.1021/acs.macromol.4c00949

Nanotechnology-based drug delivery for breast cancer treatment: Current applications and future directions
Md Abdus Samad, Iftikhar Ahmad, Torki A. Zughaibi, Mohd Suhail, Syed Kashif Zaidi, Fahad A. Al-Abbasi and Shams Tabrez
European Journal of Medicinal Chemistry Reports, 2025, 14, 100268
DOI: 10.1016/j.ejmcr.2025.100268

Stimuli-responsive nano-assemblies for remotely controlled drug delivery
Fangyuan Li, Yu Qin, Jiyoung Lee, Hongwei Liao, Nan Wang, Thomas P. Davis, Ruirui Qiao and Daishun Ling
Journal of Controlled Release, 2020, 322, 566
DOI: 10.1016/j.jconrel.2020.03.051

Thermomagneto-Responsive Smart Biocatalysts for Malonyl-Coenzyme A Synthesis
Baiju P. Krishnan, Lizbeth Ofelia Prieto-López, Sandra Hoefgen, Lulu Xue, Sheng Wang, Vito Valiante and Jiaxi Cui
ACS Appl. Mater. Interfaces, 2020, 12, 20982
DOI: 10.1021/acsami.0c04344

Redox-Activatable Theranostic Co-Prodrug for Precise Tumor Diagnosis and Selective Combination Chemotherapy
Jianqiang Qian, Zhongyuan Xu, Chi Meng, Yun Liu, Hongmei Wu, Yunyun Wang, Jinxian Yang, Hongwei Zheng, Fansheng Ran, Gong-Qing Liu and Yong Ling
J. Med. Chem., 2022, 65, 10393
DOI: 10.1021/acs.jmedchem.2c00130

Tumor microenvironment-responsive self-assembled drug-drug conjugate nanosystems: A smart platform for precision cancer therapy
Xiuyun Li, Wanpeng Yu, Yujing Zhang, Haibo Zhao, Jianwei Wang, Min Sun, Dongming Xing and Chao Wang
Coordination Chemistry Reviews, 2026, 547, 217097
DOI: 10.1016/j.ccr.2025.217097

Emerging selenium-containing nano-systems for cancer therapy
Bowen Zhang, Xin Wang, Yi Zheng, Minglong Huang, Qing Wang, Jin Sun, Zhonggui He, Lingxiao Li and Bingjun Sun
Coordination Chemistry Reviews, 2026, 548, 217159
DOI: 10.1016/j.ccr.2025.217159

AND-Logic-Based Dual-Lock Hemicyanine Fluorescence Probe for Accurate Hypoxia Assessment in Tumors
Yurong Liu, Yaru Wang, Wei Sun, Yue Li, Xuan Zhou, Junjie Chen, Shanshan Jiang, Hengke Liu, Peng Huang and Jing Lin
Chemical & Biomedical Imaging, 2026, 4, 619
DOI: 10.1021/cbmi.5c00145

Dendrimer grafted persistent luminescent nanoplatform for aptamer guided tumor imaging and acid-responsive drug delivery
Hong-Jiao Zhang, Xu Zhao, Li-Jian Chen, Cheng-Xiong Yang and Xiu-Ping Yan
Talanta, 2020, 219, 121209
DOI: 10.1016/j.talanta.2020.121209

Endogenous tumor microenvironment-responsive multifunctional nanoplatforms for precision cancer theranostics
Cong Wang, Shuizi Ding, Shaoxiong Wang, Zikuan Shi, Nil Kanatha Pandey, Lalit Chudal, Lingyun Wang, Zijian Zhang, Yu Wen, Hongliang Yao, Liangwu Lin, Wei Chen and Li Xiong
Coordination Chemistry Reviews, 2021, 426, 213529
DOI: 10.1016/j.ccr.2020.213529

A ratiometric fluorescence nanoprobe for ultrafast imaging of hypochlorite in living cells and zebrafish
Xiaoqing Wang, Jingjing Zhang, Yijing Cui, Hong Wang, Wen Lu and Li Xu
Microchemical Journal, 2022, 183, 107998
DOI: 10.1016/j.microc.2022.107998

Nitroreductase-Induced Bioorthogonal Ligation for Prodrug Activation: A Traceless Strategy for Cancer-Specific Imaging and Therapy
Liangkui Hu, Bing Li, Yulong Liao, Simeng Wang, Peng Hou, Yangyang Cheng and Shiyong Zhang
SSRN Journal, 2022
DOI: 10.2139/ssrn.4156111

Hybrid Graphene‐Gold Nanoparticle‐Based Nucleic Acid Conjugates for Cancer‐Specific Multimodal Imaging and Combined Therapeutics
Letao Yang, Tae‐Hyung Kim, Hyeon‐Yeol Cho, Jeffrey Luo, Jong‐Min Lee, Sy‐Tsong Dean Chueng, Yannan Hou, Perry To‐Tien Yin, Jiyou Han, Jong Hoon Kim, Bong Geun Chung, Jeong‐Woo Choi and Ki‐Bum Lee
Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202006918

Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases
Niuniu Yang, Mengyuan Sun, Huixin Wang, Danlei Hu, Aoxue Zhang, Suliman Khan, Zhen Chen, Dongmei Chen and Shuyu Xie
Advances in Colloid and Interface Science, 2024, 324, 103078
DOI: 10.1016/j.cis.2024.103078

Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview
Hiral Kapalatiya, Yamini Madav, Varunesh Sanjay Tambe and Sarika Wairkar
Drug Deliv. and Transl. Res., 2022, 12, 1293
DOI: 10.1007/s13346-021-01020-6

Organelle-inspired supramolecular nanomedicine to precisely abolish liver tumor growth and metastasis
Jie Zhan, Yuhan Wang, Shaodan Ma, Qin Qin, Ling Wang, Yanbin Cai and Zhimou Yang
Bioactive Materials, 2022, 9, 120
DOI: 10.1016/j.bioactmat.2021.07.021

Folate-targeting and reduction-responsive nano-delivery system based on curcumin polymer to enhance the anti-cancer activity
Wenjing Ren, Huiru Zhu, Dongshuai Shang, Xinyu Zhou, Hua Zhang, Juan Zhang, Guangpu Liu, Yunbo Wei, Kaiming Wang, Chengshi Jiang and Ping Sun
Journal of Drug Delivery Science and Technology, 2025, 105, 106616
DOI: 10.1016/j.jddst.2025.106616

Ultrasound triggered local sequential reactive oxygen species and nitric oxide release for enhanced cerasomal drug delivery
Ruiqi Wu, Yuan Wang, Suhui Sun, Qingshuang Tang, Jinxia Zhang, Chaoyi Chen, Shuyu Xu, Xiaotu Ma and Xiaolong Liang
Chemical Engineering Journal, 2024, 486, 150134
DOI: 10.1016/j.cej.2024.150134

Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy
Zesen Li, Zhuoran Li, Zhongyuan Cheng, Claudia Borri, Ambra Giannetti, Ni Lan, Junqiu Long, Wenwei Chen, Xiangran Cai, Jingge Yang, Bai-Ou Guan, Francesco Chiavaioli and Yang Ran
Light Sci Appl, 2026, 15
DOI: 10.1038/s41377-026-02219-3

Towards precision medicine using biochemically triggered cleavable conjugation
Badri Parshad, Smriti Arora, Balram Singh, Yuanwei Pan, Jianbin Tang, Zhigang Hu and Hirak K. Patra
Commun Chem, 2025, 8
DOI: 10.1038/s42004-025-01491-5

Multifunctional peptides for tumor therapy
Ke Li, Chuan-Jun Liu and Xian-Zheng Zhang
Advanced Drug Delivery Reviews, 2020, 160, 36
DOI: 10.1016/j.addr.2020.10.009

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics
Alexander B. Cook and Paolo Decuzzi
ACS Nano, 2021, 15, 2068
DOI: 10.1021/acsnano.0c09115

Endogenous Enzyme‐Operated Spherical Nucleic Acids for Cell‐Selective Protein Capture and Localization Regulation
Qing Liu, Yuanyu Huang, Lele Li, Zhengping Li and Mengyuan Li
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202214958

Carboxylated paclitaxel prodrug nanofibers for enhanced chemotherapy
Shaojin Lu, Dengyuan Hao, Xiujuan Xiang, Qing Pei and Zhigang Xie
Journal of Controlled Release, 2023, 355, 528
DOI: 10.1016/j.jconrel.2023.02.013

Electrochemical Detection of miRNA Combining T7 Exonuclease-Assisted Cascade Signal Amplification and DNA-Templated Copper Nanoparticles
Peng Miao, Tian Zhang, Jianhua Xu and Yuguo Tang
Anal. Chem., 2018, 90, 11154
DOI: 10.1021/acs.analchem.8b03425

Electrically Triggered Fluorescein and Dexamethasone Release from Conducting Polymer Hydrogels
Matthew S. Horrocks, Kirill E. Zhurenkov, Matthew S. Ting, Darren Svirskis and Jenny Malmström
Tissue Engineering Part A, 2026
DOI: 10.1177/19373341251373100

One-Pot Synthesis of Enzyme and GSH Dual-Responsive Zwitterionic Copolymers with Cross-Linked Shells for Enhanced Anticancer Drug Delivery
Fangjun Liu, Jiaqi Wang, Yang Qin, Bo Huang, Chaoyi Liu, Huiru Zhang, Cui-Yun Yu and Hua Wei
ACS Appl. Polym. Mater., 2025, 7, 2061
DOI: 10.1021/acsapm.4c03864

Responsive Zwitterionic Materials for Enhanced Drug Delivery
Ke Zheng, Xumei Ouyang, Hong Xie and Shaojun Peng
Langmuir, 2025, 41, 3744
DOI: 10.1021/acs.langmuir.4c04809

Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma
Muhammad Ismail, Yibin Wang, Yundong Li, Jiayi Liu, Meng Zheng and Yan Zou
Biomacromolecules, 2024, 25, 6250
DOI: 10.1021/acs.biomac.4c00722

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems
Shi Su and Peter M. Kang
Pharmaceutics, 2020, 12, 837
DOI: 10.3390/pharmaceutics12090837

Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy
Ya-Nan Hao, Cong-Cong Qu, Yang Shu, Jian-Hua Wang and Wei Chen
Nanomaterials, 2021, 11, 1843
DOI: 10.3390/nano11071843

Hydrogel-Encapsulated Heterogenous Mesoporous Resin Catalyst for In Situ Anti-Cancer Agent Production under Biological Conditions
Mahboubeh Nabavinia, Baishali Kanjilal, Manoj Pandey, Subash Jonnalagadda, Robert Hesketh, Manuela Martins-Green and Iman Noshadi
Biomolecules, 2022, 12, 1796
DOI: 10.3390/biom12121796

Recent Organic Photosensitizer Designs for Evoking Proinflammatory Regulated Cell Death in Antitumor Immunotherapy
Xuan Sun, Min Li, Peng Wang, Qingqing Bai, Xuchen Cao and Duo Mao
Small Methods, 2023, 7
DOI: 10.1002/smtd.202201614

Smart drug delivery systems for precise cancer therapy
Xiaoyou Wang, Chong Li, Yiguang Wang, Huabing Chen, Xinxin Zhang, Cong Luo, Wenhu Zhou, Lili Li, Lesheng Teng, Haijun Yu and Jiancheng Wang
Acta Pharmaceutica Sinica B, 2022, 12, 4098
DOI: 10.1016/j.apsb.2022.08.013

Putting Hybrid Nanomaterials to Work for Biomedical Applications
Dong Zhang, Yidan Chen, Min Hao and Younan Xia
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319567

Nanoparticle drug delivery systems responsive to tumor microenvironment: Promising alternatives in the treatment of triple‐negative breast cancer
Ye Cao, Fansu Meng, Tiange Cai, Lanwen Gao, Jaiwoo Lee, Sergey O. Solomevich, Uladzislau E. Aharodnikau, Tingting Guo, Meng Lan, Fengjie Liu, Qianwen Li, Timoshenko Viktor, Detang Li and Yu Cai
WIREs Nanomed Nanobiotechnol, 2024, 16
DOI: 10.1002/wnan.1950

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth
Rongtao Huang, Zhaoyang Ding, Bang‐Ping Jiang, Zilan Luo, Ting Chen, Zhengxi Guo, Shi‐Chen Ji, Hong Liang and Xing‐Can Shen
Small, 2020, 16
DOI: 10.1002/smll.202004345

Reconstitution of microtubule into GTP-responsive nanocapsules
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima and Takuzo Aida
Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-33156-5

Esterase-Responsive Polypeptide Vesicles as Fast-Response and Sustained-Release Nanocompartments for Fibroblast-Exempt Drug Delivery
Weihua Duan, Sifan Ji, Yu Guan, Xueluer Mu, Sha Fang, Yingxi Lu, Xianfeng Zhou, Jing Sun and Zhibo Li
Biomacromolecules, 2020, 21, 5093
DOI: 10.1021/acs.biomac.0c01251

Shape morphing of hydrogels by harnessing enzyme enabled mechanoresponse
Kuan Zhang, Yu Zhou, Junsheng Zhang, Qing Liu, Christina Hanenberg, Ahmed Mourran, Xin Wang, Xiang Gao, Yi Cao, Andreas Herrmann and Lifei Zheng
Nat Commun, 2024, 15
DOI: 10.1038/s41467-023-44607-y

Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Shaojun Peng, Fengfeng Xiao, Meiwan Chen and Huile Gao
Advanced Science, 2022, 9
DOI: 10.1002/advs.202103836

Bio‐Responsive Hyaluronic Acid‐Stearylamine Copolymer as an Enzyme Responsive Drug Carrier System: Intelligent Fusidic Acid Loaded Nanomicelles for Potential Treatment of Bacterial Wound Infections
Noor Ullah, Asim ur Rehman, Parsa Gul, Dildar Khan, Naveed Ahmad, Irfa Basharat Rajput and Kifayat Ullah Shah
J of Applied Polymer Sci, 2025, 142
DOI: 10.1002/app.57771

Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy
Haitao Sun, Qin Zhang, Jingchao Li, Shaojun Peng, Xiaolin Wang and Rong Cai
Nano Today, 2021, 37, 101073
DOI: 10.1016/j.nantod.2020.101073

Nanofibers in Organelles: From Structure Design to Biomedical Applications
Jing‐Jing Hu, Niya Lin, Yunfan Zhang, Fan Xia and Xiaoding Lou
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202313139

Stimuli‐responsive magnesium‐based materials for biomedical applications: A review
Xianli Wang, Yanbin Zhao, Qiangsheng Dong, Chenglin Chu, Feng Xue, Cheng Wang and Jing Bai
Responsive Materials, 2025, 3
DOI: 10.1002/rpm.20240037

Design strategies for aggregation-induced emission photosensitizers with enhanced safety in photodynamic therapy
Jucai Gao, Yu Tian, Yonggang Li, Fang Hu and Wenbo Wu
Coordination Chemistry Reviews, 2024, 507, 215756
DOI: 10.1016/j.ccr.2024.215756

Smart stimuli-responsive biomaterials for oral and maxillofacial tissue repair and regeneration
Yixuan Jiang, Xingrui Li, Zhuozhen Li, Hanyu Jiang, Bin Wang and Lin Xiang
Chemical Engineering Journal, 2025, 524, 168339
DOI: 10.1016/j.cej.2025.168339

Endogenous Enzyme‐Operated Spherical Nucleic Acids for Cell‐Selective Protein Capture and Localization Regulation
Qing Liu, Yuanyu Huang, Lele Li, Zhengping Li and Mengyuan Li
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202214958

Mesoporous silica nanoparticles: Synthesis and multifaceted functionalization for controlled drug delivery
Jayesh Gupta, Mural Quadros and Munira Momin
Journal of Drug Delivery Science and Technology, 2023, 81, 104305
DOI: 10.1016/j.jddst.2023.104305

Recent Development of Photofunctional Transition Metal−Peptide Conjugates for Bioimaging and Therapeutic Applications
Lawrence Cho‐Cheung Lee, Lili Huang, Peter Kam‐Keung Leung and Kenneth Kam‐Wing Lo
Eur J Inorg Chem, 2022, 2022
DOI: 10.1002/ejic.202200455

Update on modified chitosan frameworks and their applications for food, wastewater, toxic heavy metals, dyes treatment and cancer drug delivery
Anil Kumar Sahdev, Chaitany Jayprakash Raorane, Divya Shastri, Vinit Raj, Anita Singh and Seong Cheol Kim
Journal of Environmental Chemical Engineering, 2022, 10, 108656
DOI: 10.1016/j.jece.2022.108656

From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications
Yue Yin, Qiaoqiao Zhao, Zihan Wang, Zixuan Li, Hening Liu, Fatemeh Eghbalitabar, Jing Shang, Lu Tang and Wei Wang
Acta Pharmaceutica Sinica B, 2026, 16, 1804
DOI: 10.1016/j.apsb.2026.01.021

Recent advances of bioresponsive polymeric nanomedicine for cancer therapy
Tu Hong, Xinyuan Shen, Madiha Zahra Syeda, Yang Zhang, Haonan Sheng, Yipeng Zhou, JinMing Xu, Chaojie Zhu, Hongjun Li, Zhen Gu and Longguang Tang
Nano Res., 2023, 16, 2660
DOI: 10.1007/s12274-022-5002-2

Nanocosmeceuticals for Dermatological and Aesthetic Applications: Bridging Material Innovation with Clinical and Regulatory Translation
Tianzhi Zhao, Wenyao Zhen, Xiaoyuan Chen and Jingjing Zhang
ACS Nano Med., 2026, 1, 302
DOI: 10.1021/acsnanomed.5c00046

Stimuli‐Sensitive Linear–Dendritic Block Copolymer–Drug Prodrug as a Nanoplatform for Tumor Combination Therapy
Hao Cai, Ping Tan, Xiaoting Chen, Michal Kopytynski, Dayi Pan, Xiuli Zheng, Lei Gu, Qiyong Gong, Xiaohe Tian, Zhongwei Gu, Hu Zhang, Rongjun Chen and Kui Luo
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202108049

Putting Hybrid Nanomaterials to Work for Biomedical Applications
Dong Zhang, Yidan Chen, Min Hao and Younan Xia
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202319567

Recent progress in the design and antitumor application of iridium(III) photosensitizers
Qiaoshan Lie and Hui Chao
Sci. Sin.-Chim, 2024, 54, 1522
DOI: 10.1360/SSC-2024-0091

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems
Xing Qin and Yongsheng Li
ChemBioChem, 2020, 21, 1236
DOI: 10.1002/cbic.201900550

Microneedle patch tattoos
Song Li, Youngeun Kim, Jeong Woo Lee and Mark R. Prausnitz
iScience, 2022, 25, 105014
DOI: 10.1016/j.isci.2022.105014

Redox-activated photosensitizers for visualizing precise diagnosis and potentiating cancer therapy
Shuwen Fu, Zixuan Chen, Li Li, Yinwei Wu, Yalan Liao and Xingshu Li
Coordination Chemistry Reviews, 2024, 507, 215734
DOI: 10.1016/j.ccr.2024.215734

Electro‐Stimulated Graphene‐Polymer Nanocomposites Enable Wearable Patches With Feedback‐Controlled Drug Release
Santosh K. Misra, Ketan Dighe, Pranay Saha, Teresa Aditya, Muhammad S. Khan, Maha Alafeef, Parikshit Moitra and Dipanjan Pan
Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202505894

Emerging 2D material-based nanocarrier for cancer therapy beyond graphene
Yingwei Wang, Meng Qiu, Miae Won, Eugeine Jung, Taojian Fan, Ni Xie, Sung-Gil Chi, Han Zhang and Jong Seung Kim
Coordination Chemistry Reviews, 2019, 400, 213041
DOI: 10.1016/j.ccr.2019.213041

Multiplexed Imaging with Coordination Nanoparticles for Cancer Diagnosis and Therapy
Jie Feng, Zhen Xu, Dan Luo and Xiaoqing Liu
ACS Appl. Bio Mater., 2020, 3, 713
DOI: 10.1021/acsabm.9b01038

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment
Hao Xiao, Gui‐long Wu, Senyou Tan, Xiaofeng Tan and Qinglai Yang
Chemistry — An Asian Journal, 2024, 19
DOI: 10.1002/asia.202301036

Nanodynamic therapies for osteosarcoma: Recent advances and future perspectives
Yujia Xin, Jialing Yao, Wenyan Qiao, Wan Liu, Xiufu Hua, Xiaoyan Zheng, Junfeng Hui and Daidi Fan
Chemical Engineering Journal, 2026, 527, 171582
DOI: 10.1016/j.cej.2025.171582

Water dispersible cobalt single-atom catalysts with efficient Chemiluminescence enhancement for sensitive bioassay
Shuai Luo, Jiaqi Gao, Ying Chen, Hui Ouyang, Lin Wang and Zhifeng Fu
Talanta, 2022, 250, 123732
DOI: 10.1016/j.talanta.2022.123732

Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics
Bo Zhou, Zhengxi Guo, Zhaoxin Lin, Bang‐Ping Jiang and Xing‐Can Shen
ChemMedChem, 2021, 16, 919
DOI: 10.1002/cmdc.202000831

Chitosan/gelatin hybrid nanogel containing doxorubicin as enzyme-responsive drug delivery system for breast cancer treatment
Shaghayegh Aslzad, Parisa Heydari, Elaheh Dalir Abdolahinia, Nazanin Amiryaghoubi, Azam Safary, Marziyeh Fathi and Hamid Erfan-Niya
Colloid Polym Sci, 2023, 301, 273
DOI: 10.1007/s00396-023-05066-5

Radioiodine based biomedical carriers for cancer theranostics
Jingru Guo, Hehua Xiong, Huihui Liu, Tao Zhang and Xiaolian Sun
Coordination Chemistry Reviews, 2023, 497, 215430
DOI: 10.1016/j.ccr.2023.215430

Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy
Di Chang, Yuanyuan Ma, Xiaoxuan Xu, Jinbing Xie and Shenghong Ju
Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.707319

Hydrophobicity Effects of γ-Glutamyl Transpeptidase-Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy
Quan Zhou, Jianxiang Huang, Lingqiao Hao, Yu Geng, Changhuo Xu, Zhuxian Zhou, Jianbin Tang, Ruhong Zhou and Youqing Shen
Bioconjugate Chem., 2022, 33, 2132
DOI: 10.1021/acs.bioconjchem.2c00391

Emerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy
Kaiyue Song, Jiang Ming, Bailong Tao, Feng Zhao, Shaorong Huang, Wencheng Wu, Cong Jiang and Xianglong Li
Journal of Controlled Release, 2025, 381, 113580
DOI: 10.1016/j.jconrel.2025.02.076

Stimuli‐Responsive Iron Oxide Nanotheranostics: A Versatile and Powerful Approach for Cancer Therapy
Morgan E. Lorkowski, Prabhani U. Atukorale, Ketan B. Ghaghada and Efstathios Karathanasis
Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202001044

Infection microenvironment-responsive multifunctional peptide coated gold nanorods for bimodal antibacterial applications
Guoping Sheng, Jiali Ni, Kuoran Xing, Linxiao Fan, Tingting Dai, Jiawei Yu, Xiahong Dai, Richai Chen, Jiajun Wu, Nan Li, Jin Chen, Zhengwei Mao and Lanjuan Li
Colloid and Interface Science Communications, 2021, 41, 100379
DOI: 10.1016/j.colcom.2021.100379

Visible Light‐Triggered Precision SO2 Release from Polymeric Nanomedicine for Cancer Therapy
Anushree Mondal, Swastika Dey, Soumya Paul, Arnab Gupta and Priyadarsi De
Small, 2025, 21
DOI: 10.1002/smll.202502727

Liposome-Stabilized Black Phosphorus for Photothermal Drug Delivery and Oxygen Self-Enriched Photodynamic Therapy
Luo Hai, Anman Zhang, Xu Wu, Hong Cheng, Dinggeng He, Tianzheng Wang, Xiaoxiao He and Kemin Wang
ACS Appl. Nano Mater., 2020, 3, 563
DOI: 10.1021/acsanm.9b02119

Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer
Yanshu Wang, Liping Jiang, Yuwen Zhang, Yimei Lu, Jinning Li, He Wang, Defan Yao and Dengbin Wang
ACS Appl. Mater. Interfaces, 2020, 12, 33564
DOI: 10.1021/acsami.0c10397

Intracellular Activation of Bioorthogonal Nanozymes through Endosomal Proteolysis of the Protein Corona
Xianzhi Zhang, Yuanchang Liu, Sanjana Gopalakrishnan, Laura Castellanos-Garcia, Gengtan Li, Morgane Malassiné, Imad Uddin, Rui Huang, David C. Luther, Richard W. Vachet and Vincent M. Rotello
ACS Nano, 2020, 14, 4767
DOI: 10.1021/acsnano.0c00629

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Qiang Lu, Dongquan Kou, Shenghan Lou, Milad Ashrafizadeh, Amir Reza Aref, Israel Canadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan and Peng Han
J Hematol Oncol, 2024, 17
DOI: 10.1186/s13045-024-01535-8

Smart Nanotherapeutics and Lung Cancer
Mohammad Doroudian, Mohammad H. Azhdari, Nima Goodarzi, David O’Sullivan and Seamas C. Donnelly
Pharmaceutics, 2021, 13, 1972
DOI: 10.3390/pharmaceutics13111972

Advance Progress in Assembly Mechanisms of Carrier-Free Nanodrugs for Cancer Treatment
Xiaoyu Zhang, Shuyang Hu, Lifei Huang, Xiyue Chen, Xin Wang, Ya-nan Fu, Hui Sun, Guofeng Li and Xing Wang
Molecules, 2023, 28, 7065
DOI: 10.3390/molecules28207065

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications
Wenting Zhang, Jiawei Zhu, Jinsong Ren and Xiaogang Qu
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202405318

Research review of enzyme-responsive packaging in food preservation
Chaoping Jiang, Yu Hao, Zichun Jin, Jialin Liu and Wenxiu Sun
Food Sci Biotechnol, 2026, 35, 775
DOI: 10.1007/s10068-025-01965-1

Gold Nanoparticle-Incorporated Chitosan Nanogels as a Theranostic Nanoplatform for CT Imaging and Tumour Chemotherapy
Zhe Liu, Dong Zhou, Xuan Yan, Lan Xiao, Pei Wang, Junchao Wei and Lan Liao
IJN, 2022, Volume 17, 4757
DOI: 10.2147/IJN.S375999

Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer
Marziyeh Fathi, Jaleh Barar, Hamid Erfan-Niya and Yadollah Omidi
International Journal of Biological Macromolecules, 2020, 154, 1175
DOI: 10.1016/j.ijbiomac.2019.10.272

Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment
Shicui Luo, Zhuo Lv, Qiuqiong Yang, Renjie Chang and Junzi Wu
Pharmaceutics, 2023, 15, 1928
DOI: 10.3390/pharmaceutics15071928

Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence
Fei Ding, Jing Feng, Xueli Zhang, Jielin Sun, Chunhai Fan and Zhilei Ge
Advanced Drug Delivery Reviews, 2021, 173, 141
DOI: 10.1016/j.addr.2021.03.008

Polymeric Drugs via Multicomponent Reactions
Zeyu Ma, Chongyu Zhu and Lei Tao
Macromol. Rapid Commun., 2026, 47
DOI: 10.1002/marc.202500731

CRISPR-Cas9 Gene Therapy: Non-Viral Delivery and Stimuli-Responsive Nanoformulations
Hyunwoo Lee, Won-Yeop Rho, Yoon-Hee Kim, Hyejin Chang and Bong-Hyun Jun
Molecules, 2025, 30, 542
DOI: 10.3390/molecules30030542

Stimuli-responsive antimicrobial polymer systems: From structural design to biomedical applications
Jia Guo, Yaqi Tao, Zhen Du, Siqi Zhang, Wei Zheng, Zhibo Wang, Zhuomin Yi, Yangqing Gou and Wen Tang
Giant, 2025, 24, 100366
DOI: 10.1016/j.giant.2025.100366

Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy
Xiaoting Gao, Shanshan Jiang, Chunying Li, Yunzhi Chen, Yifan Zhang, Peng Huang and Jing Lin
Biomaterials, 2021, 267, 120454
DOI: 10.1016/j.biomaterials.2020.120454

Self-Assembled Hybrid Nanogel as a Multifunctional Theranostic Probe for Enzyme-Regulated Ultrasound Imaging and Tumor Therapy
Qing Wu, Qi Zhang, Tianyu Yu, Xia Wang, Chunping Jia, Zonghui Zhao and Jianlong Zhao
ACS Appl. Bio Mater., 2021, 4, 4244
DOI: 10.1021/acsabm.1c00079

Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection
Lulu Jin, Fangfang Cao, Yong Gao, Chenyin Zhang, Zhefeng Qian, Jiaojiao Zhang and Zhengwei Mao
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202301349

Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy
Cheng Xu, Yuyan Jiang, Jingsheng Huang, Jiaguo Huang and Kanyi Pu
Advanced Materials, 2021, 33
DOI: 10.1002/adma.202101410

Hydrogen Sulfide Dual-Activated NIR-II Photoacoustic Probes for Accurate Imaging and Efficient Photothermal Therapy of Colon Cancer
Shulong Wang, Liangliang Zhang, Jingjin Zhao, Li Hou, Changchun Wen, Hong Liang and Shulin Zhao
ACS Appl. Bio Mater., 2021, 4, 974
DOI: 10.1021/acsabm.0c01428

Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films
Mark D Ashton, Isabel C Appen, Melike Firlak, Naomi E Stanhope, Christine E Schmidt, William R Eisenstadt, Byul Hur and John G Hardy
Polymer International, 2021, 70, 467
DOI: 10.1002/pi.6089

Nanomedicine from amphiphilized prodrugs: Concept and clinical translation
Jiajia Xiang, Xin Liu, Guiping Yuan, Runnan Zhang, Quan Zhou, Tao Xie and Youqing Shen
Advanced Drug Delivery Reviews, 2021, 179, 114027
DOI: 10.1016/j.addr.2021.114027

Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing
Tengfei Liu, Yifei Lu, Rixing Zhan, Wei Qian and Gaoxing Luo
Advanced Drug Delivery Reviews, 2023, 193, 114670
DOI: 10.1016/j.addr.2022.114670

Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy
Dao Shi, Nan Wang, Jie Zhang, Xi Hu, Qiyue Wang, Ruixue Xiao, Baoyue Ding, Fangyuan Li and Daishun Ling
Nano Res., 2023, 16, 11125
DOI: 10.1007/s12274-023-5844-2

Toward the Specificity of Bare Nanomaterial Surfaces for Protein Corona Formation
Fabio Vianello, Alessandro Cecconello and Massimiliano Magro
IJMS, 2021, 22, 7625
DOI: 10.3390/ijms22147625

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma
Tianci Yu, Zongyan Cai, Xingyu Chang, Chengwei Xing, Sylvia White, Xiaoxue Guo and Jiaxin Jin
Orthopaedic Surgery, 2023, 15, 2244
DOI: 10.1111/os.13806

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications
Meng Yang, Yuanyuan Shi, Feng Wang, Xin Zhang, Jiayi Shao, Fan Yang, Hao Sun, Chong Zhang, Zheng Zhou, Jianyong Huang, Pengyu Lv, Patrick Shu‐Hang Yung, Jin Cheng, Hong‐Jie Huang and Jian‐Quan Wang
MedComm, 2025, 6
DOI: 10.1002/mco2.70423

Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications
Yan Zhang, Fang Lei, Wanlong Qian, Chengfeng Zhang, Qi Wang, Chaoqun Liu, Haiwei Ji, Zhengwei Liu and Faming Wang
Journal of Controlled Release, 2024, 373, 929
DOI: 10.1016/j.jconrel.2024.07.073

Erastin-induced multi-pathway cell death in endometriosis: a mechanistic and translational narrative review
Zhe Gao and Juan Du
Front. Med., 2025, 12
DOI: 10.3389/fmed.2025.1594702

Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles
Carmen Paus, Robbert van der Voort and Alessandra Cambi
Exploration of Medicine, 2021
DOI: 10.37349/emed.2021.00040

Dual Enzyme Cascade-Activated Popcorn-Like Nanoparticles Efficiently Remodeled Stellate Cells to Alleviate Pancreatic Desmoplasia
Jinxu Cao, Jing Wu, Peng Yang, Kang Qian, Yunlong Cheng, Minjun Xu, Dongyu Sheng, Ran Meng, Tianying Wang, Yixian Li, Yan Wei and Qizhi Zhang
ACS Nano, 2023, 17, 19793
DOI: 10.1021/acsnano.3c03838

“Smart” stimuli-responsive biomaterials revolutionizing the theranostic landscape of inflammatory arthritis
Sagnik Nag, Sourav Mohanto, Mohammed Gulzar Ahmed and Vetriselvan Subramaniyan
Materials Today Chemistry, 2024, 39, 102178
DOI: 10.1016/j.mtchem.2024.102178

Novel, Self-Distinguished, Dual Stimulus-Responsive Therapeutic Nanoplatform for Intracellular On-Demand Drug Release
Heng Sun, Zhongxiong Fan, Sijin Xiang, Wenbao Zuo, Yifan Yang, Doudou Huang, Guanghao Su, Xu Fu, Qingliang Zhao and Zhenqing Hou
Mol. Pharmaceutics, 2020, 17, 2435
DOI: 10.1021/acs.molpharmaceut.0c00165

Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies
Hongxu Liu, Hung-Hsun Lu, Yasin Alp, Ruiling Wu and S. Thayumanavan
Progress in Polymer Science, 2024, 148, 101765
DOI: 10.1016/j.progpolymsci.2023.101765

Dynamic DNA-based biomaterials interacting with external, macroscopic, and molecular stimuli
Shuaidong Huo, Minseok Kwak, Jingbo Qin, Barbara Dittrichn and Andreas Herrmann
Materials Today, 2021, 49, 378
DOI: 10.1016/j.mattod.2021.04.010

Hydrogel design strategies for drug delivery
Cécile A. Dreiss
Current Opinion in Colloid & Interface Science, 2020, 48, 1
DOI: 10.1016/j.cocis.2020.02.001

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications
Bole Li, Xiaotong Xu, Yanfei Lv, Zhaohui Wu, Lei He and Yu‐Fei Song
Small, 2024, 20
DOI: 10.1002/smll.202305539

Biomedical and environmental applications via nanobiocatalysts and enzyme immobilization
Yosri A. Fahim, Waleed Mahmoud Ragab, Ibrahim W. Hasani and Ahmed M. El-Khawaga
Eur J Med Res, 2025, 30
DOI: 10.1186/s40001-025-02782-2

Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
Xianghong Wang, Mengyao Shan, Shike Zhang, Xin Chen, Wentao Liu, Jinzhou Chen and Xuying Liu
Advanced Science, 2022, 9
DOI: 10.1002/advs.202104843

Stimuli-Responsive Dendrimers as Nanoscale Vectors in Drug and Gene Delivery Systems: A Review Study
Niloufar Torabi Fard, Homayon Ahmad Panahi, Elham Moniri, Elham Reza Soltani and Mohammadreza Mahdavijalal
J Polym Environ, 2024, 32, 4959
DOI: 10.1007/s10924-024-03280-y

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer
Gan Huang and Shu-Ting Pan
Oxidative Medicine and Cellular Longevity, 2020, 2020, 1
DOI: 10.1155/2020/5047987

Architecture-Based Programming of Polymeric Micelles to Undergo Sequential Mesophase Transitions
Parul Rathee, Nicole Edelstein-Pardo, Francesca Netti, Lihi Adler-Abramovich, Amit Sitt and Roey J. Amir
ACS Macro Lett., 2023, 12, 814
DOI: 10.1021/acsmacrolett.3c00153

Smart Hydrogels for Advanced Drug Delivery Systems
Aydin Bordbar-Khiabani and Michael Gasik
IJMS, 2022, 23, 3665
DOI: 10.3390/ijms23073665

Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications
Yang Zhu, Yaxin Liao, Jianhua Zou, Junjie Cheng, Yuanbo Pan, Lisen Lin and Xiaoyuan Chen
Small, 2023, 19
DOI: 10.1002/smll.202300750

Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges
Weiyi He, Jiahao Wu, Jianli Liu and Jing Li
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202312116

Cyanine Polymersomes Inbreathe Gas Signaling Molecule: SO2‐Driven Bilayer Tubular Deformation for Transmembrane Traffic Regulation
Xuefeng Li, Yixin Wang and Qiang Yan
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202305290

Tuning the Cloud-Point and Flocculation Temperature of Poly(2-(diethylamino)ethyl methacrylate)-Based Nanoparticles via a Postpolymerization Betainization Approach
Matthieu P. J. Miclotte, Stefan B. Lawrenson, Spyridon Varlas, Bilal Rashid, Emma Chapman and Rachel K. O’Reilly
ACS Polym. Au, 2021, 1, 47
DOI: 10.1021/acspolymersau.1c00010

Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies
Namdev Dhas, Ritu Kudarha, Abhijeet Pandey, Ajinkya N. Nikam, Shilpa Sharma, Ashutosh Singh, Atul Garkal, Kartik Hariharan, Amanpreet Singh, Priyanka Bangar, Dattatray Yadhav, Dhaivat Parikh, Krutika Sawant, Srinivas Mutalik, Neha Garg and Tejal Mehta
Journal of Controlled Release, 2021, 333, 188
DOI: 10.1016/j.jconrel.2021.03.021

The development of light-responsive, organic dye based, supramolecular nanosystems for enhanced anticancer therapy
Hong-Bo Cheng, Yixin Cui, Rui Wang, Nahyun Kwon and Juyoung Yoon
Coordination Chemistry Reviews, 2019, 392, 237
DOI: 10.1016/j.ccr.2019.04.004

In Vivo Near-Infrared Fluorescence/Ratiometric Photoacoustic Duplex Imaging of Lung Cancer-Specific hNQO1
Xinming Zhang, Kejia Jiang, Shanshan Jiang, Feng Zhao, Penghang Chen, Peng Huang and Jing Lin
Anal. Chem., 2022, 94, 13770
DOI: 10.1021/acs.analchem.2c02153

Ancient and Emerging Nanostructures for Innovations to Fight Head and Neck Cancer
Nina Kummer, Ömür Acet, Burcu Önal Acet, Mike Blueggel, Aya Khamis, Désirée Gül, Shirley K. Knauer and Roland H. Stauber
Cells, 2026, 15, 339
DOI: 10.3390/cells15040339

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
Yongjia Huang, Tingting Wang, Qunyou Tan, Dan He, Mingjun Wu, Jingchuan Fan, Jie Yang, Cailing Zhong, Kailing Li and Jingqing Zhang
IJN, 2021, Volume 16, 4117
DOI: 10.2147/IJN.S315368

Environment-triggered nanoagent with programmed gas release performance for accelerating diabetic infected wound healing
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong and Yu Cai
Chemical Engineering Journal, 2024, 479, 147645
DOI: 10.1016/j.cej.2023.147645

Hyaluronidase-responsive polymeric nanomaterials for targeted antimicrobial therapy: Structure–function relationships and biomaterial design strategy
Nazia Tabassum, Riza Jane S. Banicod, Aqib Javaid, Young-Mog Kim and Fazlurrahman Khan
International Journal of Biological Macromolecules, 2025, 332, 148561
DOI: 10.1016/j.ijbiomac.2025.148561

Antibacterial hydrogels for skin infected wounds: frontier approaches as antibiotic alternatives therapy
Xiangyang Li, Yueying Fan, Jinfu Li, Chao Yan, Peng Wang and Chiyu Jia
Front. Cell. Infect. Microbiol., 2026, 16
DOI: 10.3389/fcimb.2026.1769669

Recent Progress in Stimuli-Induced Morphology Transformations of Block Copolymer Assemblies
Haoxiang Zeng and Derrick A. Roberts
Australian Journal of Chemistry, 2022, 75, 55
DOI: 10.1071/CH21200

Self‐Amplified Photodynamic Therapy through the 1O2‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer
Zhiyong Liu, Tianye Cao, Yudong Xue, Mengting Li, Mengsi Wu, Jonathan W. Engle, Qianjun He, Weibo Cai, Minbo Lan and Weian Zhang
Angew Chem Int Ed, 2020, 59, 3711
DOI: 10.1002/anie.201914434

Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?
Gadi Slor and Roey J. Amir
Macromolecules, 2021, 54, 1577
DOI: 10.1021/acs.macromol.0c02263

DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Fangzhi Yu, Xiangfei Li, Chuangui Sheng and Lele Li
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202409351

Surface Plasmon Resonance–Enhanced Photoacoustic Imaging and Photothermal Therapy of Endogenous H2S‐Triggered Au@Cu2O
Cheng Tao, Lu An, Jiaomin Lin, Qiwei Tian and Shiping Yang
Small, 2019, 15
DOI: 10.1002/smll.201903473

Therapeutic impacts of enzyme-responsive smart nanobiosystems
Marziyeh Fathi, Azam Safary and Jaleh Barar
Bioimpacts, 2019, 10, 1
DOI: 10.15171/bi.2020.01

Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma
Tao Feng, Zixin Tang, Johannes Karges, Jinchao Shen, Chengzhi Jin, Yu Chen, Yihang Pan, Yulong He, Liangnian Ji and Hui Chao
Biomaterials, 2023, 301, 122212
DOI: 10.1016/j.biomaterials.2023.122212

Endogenous Stimuli-Responsive DNA Nanostructures Toward Cancer Theranostics
Xiaoxue Hu, Ziqi Xu, Qianhao Min, Chao Teng and Ye Tian
Front. Nanotechnol., 2020, 2
DOI: 10.3389/fnano.2020.574328

Enzyme-Triggered DNA Sensor Technology for Spatially-Controlled, Cell-Selective Molecular Imaging
Mengyuan Li and Lele Li
Acc. Chem. Res., 2023, 56, 1482
DOI: 10.1021/acs.accounts.3c00085

ROS-Responsive Nanoparticles for Suppressing the Cytotoxicity and Immunogenicity Caused by PM2.5 Particulates
Yixian Zhang, Haolan Zhang, Zhengwei Mao and Changyou Gao
Biomacromolecules, 2019, 20, 1777
DOI: 10.1021/acs.biomac.9b00174

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications
Kai Xu, Jie Weng, Jianshu Li and Xingyu Chen
Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202300014

Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology
Cerise M. Siamof, Shreya Goel and Weibo Cai
Front. Chem., 2020, 8
DOI: 10.3389/fchem.2020.598100

Cyanine Polymersomes Inbreathe Gas Signaling Molecule: SO2‐Driven Bilayer Tubular Deformation for Transmembrane Traffic Regulation
Xuefeng Li, Yixin Wang and Qiang Yan
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202305290

A Self-Transformed N-Chlorinated ε-Polylysine Coating Endows Titanium Implants with Programmed Integration of Robust Antibacterial and Pro-Osteogenic Abilities
Junshen Huang, Youchen Tang, Peng Wang, Zhi Liang, Hang Ren, Ziying Cheng, Hanwen Huang, Ziming Wang, Yanfeng Wu, Zhongyu Xie, Dingcai Wu, Zhaopeng Cai and Huiyong Shen
Chemical Engineering Journal, 2024, 493, 152073
DOI: 10.1016/j.cej.2024.152073

Mesoporous silica nanoparticles as a versatile nanocarrier for cancer treatment: A review
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh and Azam Marjani
Journal of Molecular Liquids, 2021, 328, 115417
DOI: 10.1016/j.molliq.2021.115417

Design of ratiometric monoaromatic fluorescence probe via modulating intramolecular hydrogen bonding: A case study of alkaline phosphatase sensing
Mingce Tian, Kai Zhang, Yanjun Zhang, He Zhou, Zhiqin Yuan and Chao Lu
Analytica Chimica Acta, 2021, 1143, 144
DOI: 10.1016/j.aca.2020.11.048

Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration
Xiaojun Zhou, Shuo Chen, Andrij Pich and Chuanglong He
ACS Biomater. Sci. Eng., 2025, 11, 182
DOI: 10.1021/acsbiomaterials.4c02037

Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers
Radka Boyuklieva, Nikolay Zahariev, Plamen Simeonov, Dimitar Penkov and Plamen Katsarov
Biomedicines, 2025, 13, 1464
DOI: 10.3390/biomedicines13061464

Tethered Indoxyl-Glucuronides for Enzymatically Triggered Cross-Linking
Juno Son, Zhiyuan Wu, Jinghuai Dou, Hikaru Fujita, Phuong-Lien Doan Cao, Qihui Liu and Jonathan S. Lindsey
Molecules, 2023, 28, 4143
DOI: 10.3390/molecules28104143

Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics
Shahar Tevet, Michal Brodsky and Roey J. Amir
Biomacromolecules, 2025, 26, 7423
DOI: 10.1021/acs.biomac.5c00955

An epidermal growth factor receptor-targeted and endoplasmic reticulum-localized organic photosensitizer toward photodynamic anticancer therapy
Xuan Zhao, Haixia Ma, Juanjuan Chen, Fengling Zhang, Xiao Jia and Jinping Xue
European Journal of Medicinal Chemistry, 2019, 182, 111625
DOI: 10.1016/j.ejmech.2019.111625

Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability
Yang Fu, Yuanxin Ge, Shixiong Yi, Qifeng Peng, Heng Jiang and Jie Zhou
J Mater Sci: Mater Med, 2026, 37
DOI: 10.1007/s10856-026-07012-7

Lysozyme-Responsive Glycol Chitosan Hydrogel Facilitates On-Demand Release of Antibacterial Nanoparticles for Wound Healing Applications
Baoer Fan, Jia Guo, Siqi Zhang, Yingying Wang, Yaqi Tao, Wei Zheng, Kun Chen and Wen Tang
ACS Appl. Bio Mater., 2026, 9, 390
DOI: 10.1021/acsabm.5c01924

A Versatile Supramolecular Assembly Platform for Tumor Microenvironment Motivated Drug Release and Ferroptosis Synergistic Therapy
Dandan Liu, Min Lin, Lilei Shu, Jing Sun and Xuesi Chen
Nano Lett., 2023, 23, 5713
DOI: 10.1021/acs.nanolett.3c01440

Enzyme‐Instructed Host‐Guest Assembly/Disassembly for Biomedical Applications
Hongzhe Yan, Xiaoyang Liu, Caifeng Ding and Gaolin Liang
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202300648

Spherical Nucleic Acids as Modulators of CRISPR/Cas12a by a Steric Barrier Effect for Designing Versatile Biosensors
Fengxi Zhu and Qiang Zhao
Anal. Chem., 2025, 97, 12215
DOI: 10.1021/acs.analchem.5c00937

Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
Adenia Mirela Alves Nunes, José de Oliveira Alves Júnior, Valéria Springer Haydée and João Augusto Oshiro Júnior
CPD, 2024, 30, 2345
DOI: 10.2174/0113816128291108240613094515

Biomedical applications of stimuli‐responsive nanomaterials
Xiaojie Chen, Di Wu and Zhong Chen
MedComm, 2024, 5
DOI: 10.1002/mco2.643

Endogenous stimuli-responsive drug delivery nanoplatforms for kidney disease therapy
Hufeng Fang, Shan Xu, Yu Wang, Hao Yang and Dan Su
Colloids and Surfaces B: Biointerfaces, 2023, 232, 113598
DOI: 10.1016/j.colsurfb.2023.113598

Stimuli-Responsive Microneedle: A Novel Frontier in Melanoma Therapy
Rabinarayan Parhi
Biomedical Materials & Devices, 2025
DOI: 10.1007/s44174-025-00499-8

Smart nanophotonics for enzyme-driven drug resistance sensing and controlled therapeutic release
Bakr Ahmed Taha, Ali J. Addie, Marwa Amin Al-Rawi, Adawiya J. Haider, Amit K. Yadav, Dhiraj Bhatia, Majid S. Jabir, Khalid Hassan Ibnaouf and Norhana Arsad
Journal of Drug Delivery Science and Technology, 2025, 114, 107488
DOI: 10.1016/j.jddst.2025.107488

Self‐Amplified Photodynamic Therapy through the 1O2‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer
Zhiyong Liu, Tianye Cao, Yudong Xue, Mengting Li, Mengsi Wu, Jonathan W. Engle, Qianjun He, Weibo Cai, Minbo Lan and Weian Zhang
Angewandte Chemie, 2020, 132, 3740
DOI: 10.1002/ange.201914434

Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers
Hadiqa Zafar, Bin Liu, Hung V.-T. Nguyen and Jeremiah A. Johnson
ACS Macro Lett., 2024, 13, 571
DOI: 10.1021/acsmacrolett.4c00119

Nanomaterials for targeted therapy of kidney diseases: Strategies and advances
Zhiwen Wang and Chun Zhang
Materials Today Bio, 2025, 31, 101534
DOI: 10.1016/j.mtbio.2025.101534

Biology-Oriented Design Strategies of AIE Theranostic Probes
Duo Mao and Bin Liu
Matter, 2021, 4, 350
DOI: 10.1016/j.matt.2020.12.006

DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Fangzhi Yu, Xiangfei Li, Chuangui Sheng and Lele Li
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202409351

Smart dendrimers: Synergizing the targeting of anticancer bioactives
Vikrant Saluja, Abhinav Mankoo, Gaurav K. Saraogi, Murtaza M. Tambuwala and Vijay Mishra
Journal of Drug Delivery Science and Technology, 2019, 52, 15
DOI: 10.1016/j.jddst.2019.04.014

A core-satellite MOF-on-MOF hybrid for intelligent delivery of multi-agrochemicals for sustainable agriculture
Song Ma, Xipeng Yang, Yingjie Wang, Xin Yang, Yuhu Li and Shaoyu Lü
Applied Surface Science, 2023, 624, 157129
DOI: 10.1016/j.apsusc.2023.157129

Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging
Ramar Thangam, Ramasamy Paulmurugan and Heemin Kang
Nanomaterials, 2021, 12, 18
DOI: 10.3390/nano12010018

Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications
Xin Zhang, Han Zhang, Xiaonan Liu, Jiao Wang, Shifeng Li and Peng Gao
Polymers, 2024, 16, 3163
DOI: 10.3390/polym16223163

Antibacterial Micro/Nanorobots: Innovations, Challenges, and Future Perspectives in Combatting Infection
Yichao Chen, Chenlin Jiang, Chuxie Zhang, Wenqing He and Changshun Hou
Nano Select, 2026, 7
DOI: 10.1002/nano.70084

Tumor microenvironment activatable immunomodulator for cancer immunotherapy
Weiqi Wang, Xingxing Liu, Zijiao Yan, Ke Yan, Mengjiao Zhou, Yumin Yang and Haijun Yu
Journal of Controlled Release, 2026, 395, 114949
DOI: 10.1016/j.jconrel.2026.114949

DNA-Based nanostructures for tumor microenvironment-responsive drug delivery
Siqi Li, Mengdi Xu, Chi Yao and Dayong Yang
Advanced Drug Delivery Reviews, 2025, 223, 115610
DOI: 10.1016/j.addr.2025.115610

Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles
Jarmila Prieložná, Veronika Mikušová and Peter Mikuš
International Journal of Pharmaceutics: X, 2024, 8, 100281
DOI: 10.1016/j.ijpx.2024.100281

Recent advances in nano material-based application of liver neoplasms
Yuan Cao and Hong-Wu Zhang
Smart Materials in Medicine, 2021, 2, 114
DOI: 10.1016/j.smaim.2021.03.001

Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis
Yan Zhang, Taixia Wang, Xiulin Dong, Chunyan Zhu, Qiuxia Peng, Chang Liu, Yifeng Zhang, Fubo Chen and Kun Zhang
Advanced Science, 2024, 11
DOI: 10.1002/advs.202308439

Photothermally triggered biomimetic drug delivery of Teriparatide via reduced graphene oxide loaded chitosan hydrogel for osteoporotic bone regeneration
Xiaoting Wang, Weiming Guo, Lvyuan Li, Fei Yu, Jiayi Li, Lu Liu, Bing Fang and Lunguo Xia
Chemical Engineering Journal, 2021, 413, 127413
DOI: 10.1016/j.cej.2020.127413

Molecular Trojan Based on Membrane‐Mimicking Conjugated Electrolyte for Stimuli‐Responsive Drug Release
Yingying Meng, Ji Gao, Xiaoran Huang, Pengke Liu, Chibin Zhang, Peirong Zhou, Yuanqing Bai, Jingjing Guo, Cheng Zhou, Kai Li, Fei Huang and Yong Cao
Advanced Materials, 2025, 37
DOI: 10.1002/adma.202415705

Recent Trends in In Situ Enzyme-Activatable Prodrugs for Targeted Cancer Therapy
In-Cheol Sun, Hong Yeol Yoon, Dong-Kwon Lim and Kwangmeyung Kim
Bioconjugate Chem., 2020, 31, 1012
DOI: 10.1021/acs.bioconjchem.0c00082

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes
Craig J. Neal, Elayaraja Kolanthai, Fei Wei, Melanie Coathup and Sudipta Seal
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202211261

A review on advancements in the application of starch-based nanomaterials in biomedicine: Precision drug delivery and cancer therapy
JinJin Pei, Yuqiang Yan, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Prabhu Manickam Natarajan, Vidhya Rekha Umapathy, Sridevi Gopathy, Jeane Rebecca Roy, Janaki Coimbatore Sadagopan, Dwarakesh Thalamati, Chella Perumal Palanisamy and Monica Mironescu
International Journal of Biological Macromolecules, 2024, 265, 130746
DOI: 10.1016/j.ijbiomac.2024.130746

Recently Developed Carbohydrate Based Gelators and Their Applications
Joedian Morris, Jonathan Bietsch, Kristen Bashaw and Guijun Wang
Gels, 2021, 7, 24
DOI: 10.3390/gels7010024

Insight into the Prospects for Tumor Therapy Based on Photodynamic Immunotherapy
Xiaoxia Cheng, Yiqu Wei, Xiaomei Jiang, Chunli Wang, Mengyu Liu, Jiaxin Yan, Lei Zhang and Yaqi Zhou
Pharmaceuticals, 2022, 15, 1359
DOI: 10.3390/ph15111359

Plasmonic nanomaterials: A versatile phototheranostic platform of cancers
Zhiguo He, Can Yang Zhang, Yu Lei, Guolin Song and Youwei Yao
Materials Today, 2023, 62, 168
DOI: 10.1016/j.mattod.2022.11.011

Activatable NIR Schaap’s 1,2-Dioxetane-Based Chemiluminescent Probes for Bioimaging Applications
Meiqin Li, Chonglu Li and Yao Sun
Chemical & Biomedical Imaging, 2025
DOI: 10.1021/cbmi.5c00157

Label-free SERS-colorimetry dual-mode biosensor based on CRISPR/Cas12a triggered G-quadruplex capped magnetic meso-porous silica microspheres
Cong Wang, Wenxiao Ma, Tongtong Jia, Xiaoru Zhang and Xiaopeng Fan
Sensors and Actuators B: Chemical, 2025, 422, 136452
DOI: 10.1016/j.snb.2024.136452

Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy
Longfei Li, Ruinan Hao, Junjie Qin, Jian Song, Xiaofeng Chen, Feng Rao, Jiliang Zhai, Yu Zhao, Liqun Zhang and Jiajia Xue
Adv. Fiber Mater., 2022, 4, 1375
DOI: 10.1007/s42765-022-00198-9

Stimulus-responsive inorganic semiconductor nanomaterials for tumor-specific theranostics
Xin Hu, Enna Ha, Fujin Ai, Xiaojuan Huang, Li Yan, Shuqing He, Shuangchen Ruan and Junqing Hu
Coordination Chemistry Reviews, 2022, 473, 214821
DOI: 10.1016/j.ccr.2022.214821

Self-Adaptive Nanomaterials for Rational Drug Delivery in Cancer Therapy
Guanqing Yang, Yang Liu, Jinjin Chen, Jianxun Ding and Xuesi Chen
Acc. Mater. Res., 2022, 3, 1232
DOI: 10.1021/accountsmr.2c00147

Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy
Yang Li, Jianfeng Gao, Shuping Wang, Shijun Li, Xiaowen Hou, Yanna Pan, Jialu Gao, Xue Qiao, Zhiquan Tian, Deliang Chen, Hai Deng, Zixin Deng, Xuechuan Hong and Yuling Xiao
Journal of Controlled Release, 2022, 342, 157
DOI: 10.1016/j.jconrel.2022.01.005

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks
Gadi Slor, Alis R. Olea, Sílvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi and Roey J. Amir
Biomacromolecules, 2021, 22, 1197
DOI: 10.1021/acs.biomac.0c01708

Upconversion and downshifting of the luminescence of reticular lanthanide metal-organic frameworks for biomarker signalling: Where do we stand in 2024?
Sourav Bej, Xintian Wang, Jin Zhang, Xuemei Yang and Peng Ren
Coordination Chemistry Reviews, 2024, 513, 215862
DOI: 10.1016/j.ccr.2024.215862

Constructing mesoporous silica-grown reduced graphene oxide nanoparticles for photothermal-chemotherapy
Dongxue Guo, Huailin Yang, Yu Zhang and Li Chen
Microporous and Mesoporous Materials, 2019, 288, 109608
DOI: 10.1016/j.micromeso.2019.109608

Advances in Engineered Phages for Disease Treatment
Xiaolin Hou, Lin Zhai, Laiying Fu, Junna Lu, Peilin Guo, Yu Zhang, Diwei Zheng and Guanghui Ma
Small Methods, 2025, 9
DOI: 10.1002/smtd.202401611

Unravelling the Enzymatic Degradation Mechanism of Supramolecular Peptide Nanofibers and Its Correlation with Their Internal Viscosity
Yejiao Shi, Peter A. Summers, Marina K. Kuimova and Helena S. Azevedo
Nano Lett., 2020, 20, 7375
DOI: 10.1021/acs.nanolett.0c02781

pH/enzyme/light triple‐responsive vesicles from lysine‐based amphiphilic diblock copolymers
Guoyang Qin, Cong Hu, Yanfen Jiang, Shuqi Dong, Li Liu and Hanying Zhao
Journal of Polymer Science, 2021, 59, 1958
DOI: 10.1002/pol.20210245

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety
Lile Dong, Wenjuan Li, Lining Sun, Luodan Yu, Yu Chen and Guobin Hong
WIREs Nanomed Nanobiotechnol, 2021, 13
DOI: 10.1002/wnan.1663

Sequential enzyme-activated macrotheranostic probe for selective tumor mitochondria targeting
Di Ma, Qingyu Zong, Yuchen Du, Fangzhou Yu, Xuan Xiao, Rong Sun, Yuan Guo, Xinhua Wei and Youyong Yuan
Acta Biomaterialia, 2021, 135, 628
DOI: 10.1016/j.actbio.2021.08.002

Ultrasound-Activated Prodrugs for Tumor-Specific Immunotherapy
Wenhao Tan, Linrong Chen, Tianyu Zhang, Qianqian Mu, Muhetaerjiang Mamuti, Haoqi Wu, Siqi Li, Jing Ma, Xiqun Jiang and Xu Zhen
J. Am. Chem. Soc., 2026, 148, 11296
DOI: 10.1021/jacs.6c00735

Recent composition and applications of liposomes in cancer therapy
Iqra Noor Khan, Nida Arshad, Farwa Shaheen, Rabiya Shakoor, Ahmad Hassan and Muhammad Ahsan Waqar
International Journal of Polymeric Materials and Polymeric Biomaterials, 2025, 74, 720
DOI: 10.1080/00914037.2024.2368896

Reactive Oxygen Species (ROS)-Degradable Polymeric Nanoplatform for Hypoxia-Targeted Gene Delivery: Unpacking DNA and Reducing Toxicity
Yuxin Zhang, Jie Zhou, Shengnan Ma, Yiyan He, Jun Yang and Zhongwei Gu
Biomacromolecules, 2019, 20, 1899
DOI: 10.1021/acs.biomac.9b00054

Peptide Nanostructure-Mediated Antibiotic Delivery by Exploiting H2S-Rich Environment in Clinically Relevant Bacterial Cultures
Narendra Singh, Ramesh Singh, Manjulika Shukla, Grace Kaul, Sidharth Chopra, Khashti Ballabh Joshi and Sandeep Verma
ACS Infect. Dis., 2020, 6, 2441
DOI: 10.1021/acsinfecdis.0c00227

Nanomedicine Reimagined: Translational Strategies for Precision Tumor Theranostics
Qinghe Wu, Xiaotong Yao, Xurui Duan, Xiaoyuan Chen and Jingjing Zhang
Advanced Materials, 2026, 38
DOI: 10.1002/adma.202510293

Enzyme Responsive Magnetic Nanoparticles for Targeted Drug Delivery and Precision Medicine
Zhenchen Du, Ebraheem Abdu Musad Saleh, M. M.Moharam, Safia Obaidur Rab, Suhas Ballal, Abhayveer Singh, A. Sabarivani, Samir Sahoo and Chou‐Yi Hsu
Drug Development Research, 2025, 86
DOI: 10.1002/ddr.70185

Enzyme-Assisted Photodynamic Therapy Based on Nanomaterials
Baoji Du and Ching-Hsuan Tung
ACS Biomater. Sci. Eng., 2020, 6, 2506
DOI: 10.1021/acsbiomaterials.9b00968

Design principles for bacteria-responsive antimicrobial nanomaterials
J.Y. Quek, E. Uroro, N. Goswami and K. Vasilev
Materials Today Chemistry, 2022, 23, 100606
DOI: 10.1016/j.mtchem.2021.100606

Advances in nanomedicine strategies for modulating the tumor microenvironment: Recent progress and clinical perspectives
Talha Bin Emran, Md. Al Amin, Safia Obaidur Rab, Patibandla Jahnavi, Rajeshwar Vodeti, Jeetendra Kumar Gupta, Uppuluri Varuna Naga Venkata Arjun, T. N. Umamaheswari, P. Balaji, Girija Dayalan, Soniya Rani and Prem Shankar Gupta
3 Biotech, 2026, 16
DOI: 10.1007/s13205-025-04651-5

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface
Joshua D Simpson, Samuel A Smith, Kristofer J. Thurecht and Georgina Such
Polymers, 2019, 11, 1441
DOI: 10.3390/polym11091441

Fluorescence “Turn-On” Enzyme-Responsive Supra-Amphiphile Fabricated by Host–Guest Recognition between γ-Cyclodextrin and a Tetraphenylethylene-Sodium Glycyrrhetinate Conjugate
Qi Hao, Yuetong Kang, Jiang-Fei Xu and Xi Zhang
Langmuir, 2021, 37, 6062
DOI: 10.1021/acs.langmuir.1c00781

Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms
Xin Chen, Shan Lei, Jing Lin and Peng Huang
Expert Opinion on Drug Delivery, 2022, 19, 1487
DOI: 10.1080/17425247.2022.2134853

Carbon Dots for In Vivo Bioimaging and Theranostics
Jianjun Du, Ning Xu, Jiangli Fan, Wen Sun and Xiaojun Peng
Small, 2019, 15
DOI: 10.1002/smll.201805087

Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host–Guest Interactions
Danyu Xia, Pi Wang, Xiaofan Ji, Niveen M. Khashab, Jonathan L. Sessler and Feihe Huang
Chem. Rev., 2020, 120, 6070
DOI: 10.1021/acs.chemrev.9b00839

Glucose transporter 1 (GLUT1)-targeting and hypoxia-activated mitochondria-specific chemo-thermal therapy via a glycosylated poly(amido amine)/celastrol (PAMAM/Cel) complex
Guijie Wei, Jianhua Chen, Ziqi Jing, Yanyi Li, Zhihui Li, Wei Zheng, Xiurui Sun, Wenwen Zhao, Zhe Zhang, Xue Wang, Hongcui Han, Chu Li, Yujie Zhang and Pengkai Ma
Journal of Colloid and Interface Science, 2022, 608, 1355
DOI: 10.1016/j.jcis.2021.10.129

Nitroreductase-induced bioorthogonal ligation for prodrug activation: A traceless strategy for cancer-specific imaging and therapy
Liangkui Hu, Bing Li, Yulong Liao, Simeng Wang, Peng Hou, Yangyang Cheng and Shiyong Zhang
Bioorganic Chemistry, 2022, 129, 106167
DOI: 10.1016/j.bioorg.2022.106167

Bio‐Inspired Far‐From‐Equilibrium Hydrogels: Design Principles and Applications
Jiadong Tang, Yibo Cheng, Muhua Ding and Chen Wang
ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202300449

Engineering smart hydrogels for intelligent drug delivery
Mitra Baghali, Hakimeh Ziyadi and Antonio Di Martino
Polym. Bull., 2025, 82, 2287
DOI: 10.1007/s00289-024-05618-x

Enzyme-Responsive Materials as Carriers for Improving Photodynamic Therapy
Houhe Liu, Fanwen Yang, Wenjie Chen, Teng Gong, Yi Zhou, Xiaoyan Dai, Wingnang Leung and Chuanshan Xu
Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.763057

Current Advances in Nanotheranostics for Molecular Imaging and Therapy of Cardiovascular Disorders
Aseem Setia, Abhishesh Kumar Mehata, Vishnu Priya, Datta Maroti Pawde, Dharmendra Jain, Sanjeev Kumar Mahto and Madaswamy S. Muthu
Mol. Pharmaceutics, 2023, 20, 4922
DOI: 10.1021/acs.molpharmaceut.3c00582

Stimuli-Responsive Polymers for Sensing and Reacting to Environmental Conditions
Qiang Zhang, Yingnan Zhang, Yu Wan, Wildemar Carvalho, Liang Hu and Michael J. Serpe
Progress in Polymer Science, 2021, 116, 101386
DOI: 10.1016/j.progpolymsci.2021.101386