Penggang Han, Fuli Wang, Shaoheng Bao, Ge Yao, Xiukun Wan, JiaJia Liu and Hui Jiang
RSC Adv., 2023,13, 866-872
Abstract
The clickable and photoreactive amino acid is prepared in 11 steps from 3-(4-bromophenyl)-1-propanol.
Monika Lisauskaitė, Gemma L. Nixon, Christopher M. Woodley, Neil G. Berry, Andy Coninckx, L. Charlie Qie, Suet C. Leung, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Stephen A. Ward, Oscar Vadas, Dominique Soldati-Favre, W. David Hong and Paul M. O'Neill
RSC Chem. Biol., 2024,5, 19-29
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
We report the synthesis and biological profiling of photoreactive chemical probes based on an established plasmepsin X inhibitor scaffold. Maintained antimalarial and recombinant enzyme activity support their use in future chemical proteomic studies.
Xiangyu Wu and Min Dong
Chem. Sci., 2025,16, 12043-12050
Abstract
S-Adenosylmethionine (SAM) serves as an important substrate in a variety of biochemical reactions. We developed three SAM photoaffinity probes to label, enrich and identify SAM-binding proteins.
Ian Ford, Miranda Villanueva, Min Sub Lee, Quan D. Zhou, Constance Yuen, Robert Damoiseaux, Steven J. Bensinger and Keriann M. Backus
RSC Chem. Biol., 2025,6, 1451-1464
Abstract
Chemoproteomic and genetic approaches reveal sterol interactions with stimulator of interferon genes (STING)-sterol, with subcellular localization and activation also responsive to sterol content.
Maciej Zakrzewski, Zuzanna Sas, Benjamin Cocom-Chan, Moh Egy Rahman Firdaus, Marcin Kałek, Karolina Szczepanowska, Piotr Gerlach, Anna Marusiak and Remigiusz A. Serwa
RSC Chem. Biol., 2025,6, 1787-1796
Abstract
Photoaffinity polyamine analogs were synthesized and used to map polyamine–protein interactions in living cells, identifying over 400 protein interactors with structure-dependent specificity.