Penggang Han, Fuli Wang, Shaoheng Bao, Ge Yao, Xiukun Wan, JiaJia Liu and Hui Jiang
RSC Adv., 2023,13, 866-872
Abstract
The clickable and photoreactive amino acid is prepared in 11 steps from 3-(4-bromophenyl)-1-propanol.
Xiangyu Wu and Min Dong
Chem. Sci., 2025,16, 12043-12050
Abstract
S-Adenosylmethionine (SAM) serves as an important substrate in a variety of biochemical reactions. We developed three SAM photoaffinity probes to label, enrich and identify SAM-binding proteins.
Monika Lisauskaitė, Gemma L. Nixon, Christopher M. Woodley, Neil G. Berry, Andy Coninckx, L. Charlie Qie, Suet C. Leung, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Stephen A. Ward, Oscar Vadas, Dominique Soldati-Favre, W. David Hong and Paul M. O'Neill
RSC Chem. Biol., 2024,5, 19-29
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
We report the synthesis and biological profiling of photoreactive chemical probes based on an established plasmepsin X inhibitor scaffold. Maintained antimalarial and recombinant enzyme activity support their use in future chemical proteomic studies.
Li Shen, Yue Yang, Lijun Lu, Jili Huang, Wen He, Chunfang Zhao, Feng Guo, Chunbo Zhang, Haijun Zhong and Fan Liao
Chem. Commun., 2025,61, 669-672
Abstract
We designed and synthesized two minimalist photoaffinity probes to investigate the targets of piperine, providing a valuable tool for elucidating the pharmacologic mechanism of piperine.
Jessica G. K. O'Brien, Louis P. Conway, Paramesh K. Ramaraj, Appaso M. Jadhav, Jun Jin, Jason K. Dutra, Parrish Evers, Shadi S. Masoud, Manuel Schupp, Iakovos Saridakis, Yong Chen, Nuno Maulide, John P. Pezacki, Christopher W. am Ende, Christopher G. Parker and Joseph M. Fox
Chem. Sci., 2024,15, 15463-15473
Abstract
Linear diazirines can produce relatively long-lived diazoalkanes which are also capable of labeling proteins whereas cyclobutanediazirines are proposed to give minimal diazo product and labeling occurs predominantly via a carbene mechanism.