Two series of gold(III) bis(dithiolene) complex-based therapeutic agents displaying both anticancer and antiplasmodial activities have been synthesized and characterized.
Thiazolines and their derivatives hold significant importance in the field of medicinal chemistry due to their promising potential as pharmaceutical agents.
A facile method for selective N-(hetero)arylation of coordinating 3(5)-amino-1,2,4-triazoles under Pd/NHC catalysis using TPEDO as a new efficient Pd(II) to Pd(0) reductant has been developed.
New pyrazolylindolin-2-one linked coumarin derivatives were designed as dual BRAFV600E/VEGFR-2 inhibitors targeting melanoma cells A375. Docking simulation showed various interactions with the binding residues in BRAFV600E and VEGFR-2 active sites.
High conductivity is found in a 1 : 2 mixed-valence salt of a selone-substituted nickel bis(dithiolene) complex with a rare cis arrangement of the two dithiolene ligands around the Ni atom.