The tremendous potential of transition metal-free multi-component reactions (MCR) in the synthesis of N-heterocyclic frameworks is examined in this review, offering a complete overview of this subject matter.
Direct synthesis of 3-acylpyrroles via acceptorless dehydrogenative coupling with the merits of high step- and atom efficiency, broad substrate scope, operational simplicity, and water and hydrogen gas as the sole by-products.
The review summarizes the recent progress on manganese-catalyzed (de)hydrogenation and hydroelementation reactions. It provides a complete and critical analysis of ligand design, reaction pathways, and synthetic applications.
Direct access to a diverse range of 2-amino-4H-chromenes was established in excellent yields through a one-pot multicomponent ADC reaction of benzyl alcohols catalysed by p-cymene Ru(II) complexes under additive/promotor-free conditions.
We report a cost-effective, green, and acceptorless dehydrogenative one-pot synthesis of triazines from primary alcohols and amidines using an alumina-supported Pt nanoparticle catalyst (Pt/Al2O3).