The tremendous potential of transition metal-free multi-component reactions (MCR) in the synthesis of N-heterocyclic frameworks is examined in this review, offering a complete overview of this subject matter.
This review focuses on the application of vinyl azide in organic synthesis and highlights new strategies and methods using this compound to produce heterocycles and other organic compounds.
A novel class of Betti base-thiourea-derived bifunctional organocatalysts have been synthesized.
The copper-catalyzed three-component annulation of α,β-unsaturated ketoximes, 1,3-dicarbonyls and paraformaldehyde for the synthesis of 2,3-disubstituted pyrroles has been documented.
A chiral Brønsted acid-catalyzed methodology for the introduction of a congested tetrasubstituted stereogenic center at the β-(C3) position of 2,5-disubstituted pyrroles and at the α-(C5) position of 2-monosubstituted pyrroles is reported.