This review highlights structural diversity, biosynthesis, biomimetic synthesis, and biological functions of trimeric natural products. These biosynthetic pathways could lead to the discovery of more bioactive trimers through (bio)synthesis.
Juggling between reactivity and selectivity, free radical oxidation offers a unique means to synthesize natural products in a direct and efficient way. The case study of sesquiterpenes is illustrative of how modern total synthesis should be conducted.
A comprehensive comparison between emulsion and spray methods for the fabrication of rapamycin-loaded Ace-DEX MPs, investigating physiochemical parameters, in vitro immunosuppressive efficacy, and in vivo trafficking.
A gel composed of Manganese Glycerophosphate was able to induce robust cellular and antibody responses when co-administered as an adjuvant of subunit vaccines.
Separation-free chiral analysis of mixtures at rates relevant to high-throughput experimentation in drug development is demonstrated using an automated platform based on ambient tandem mass spectrometry and following the kinetic method.