Development of single-cell ICP-TOFMS to measure nanoplastics association with human cells

Lyndsey Hendriks, Vera M. Kissling, Tina Buerki-Thurnherr and Denise M. Mitrano

Environ. Sci.: Nano, 2023, 10, 3439
DOI: 10.1039/D3EN00681F

Two-stage semi-supervised machine learning for classification of Ti-rich nanoparticles and microparticles measured by spICP-TOFMS

Raven L. Buckman Johnson, Hark Karkee and Alexander Gundlach-Graham

J. Anal. At. Spectrom., 2025, 40, 1658
DOI: 10.1039/D5JA00108K

Quantitative sizing of microplastics up to 20 µm using ICP-TOFMS

Fazzolari Sandro, Hattendorf Bodo and Günther Detlef

J. Anal. At. Spectrom., 2025, 40, 276
DOI: 10.1039/D4JA00323C

Two-stage hierarchical clustering for analysis and classification of mineral sunscreen and naturally occurring nanoparticles in river water using single-particle ICP-TOFMS

Hark Karkee and Alexander Gundlach-Graham

Environ. Sci.: Nano, 2024, 11, 4162
DOI: 10.1039/D4EN00288A

Machine learning analysis to classify nanoparticles from noisy spICP-TOFMS data

Raven L. Buckman and Alexander Gundlach-Graham

J. Anal. At. Spectrom., 2023, 38, 1244
DOI: 10.1039/D3JA00081H

Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS

Veronica C. Bradley, Benjamin T. Manard, Lyndsey Hendriks, Daniel R. Dunlap, Amber N. Bible, Ada Sedova, Patricia Saint-Vincent, Brian C. Sanders and Hunter B. Andrews

Anal. Methods, 2024, 16, 3192
DOI: 10.1039/D4AY00268G

Particle signal considerations for isotope ratio analysis with single particle multi-collector inductively coupled plasma mass spectrometry

Sarah E. Szakas, Jordan S. Stanberry, N. Alex Zirakparvar, Hunter B. Andrews, Daniel R. Dunlap, Matt Darnell, Brian W. Ticknor, Lorianne R. Shultz-Johnson, Shawna K. Tazik and Benjamin T. Manard

J. Anal. At. Spectrom., 2025, 40, 1483
DOI: 10.1039/D5JA00107B

The elemental fingerprint as a potential tool for tracking the fate of real-life model nanoplastics generated from plastic consumer products in environmental systems

Mohammed Baalousha, Jingjing Wang, Md Mahmudun Nabi, Mahbub Alam, Mahdi Erfani, Julien Gigault, Florent Blancho, Mélanie Davranche, Phillip M. Potter and Souhail R. Al-Abed

Environ. Sci.: Nano, 2024, 11, 373
DOI: 10.1039/D3EN00559C

Measurement bias in spICP-TOFMS: insights from Monte Carlo simulations

Raven L. Buckman and Alexander Gundlach-Graham

Anal. Methods, 2024, 16, 5802
DOI: 10.1039/D4AY00859F

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

Robert Clough, Andy Fisher, Bridget Gibson and Ben Russell

J. Anal. At. Spectrom., 2023, 38, 2215
DOI: 10.1039/D3JA90038J

Advanced Optical Imaging Technologies for Microplastics Identification: Progress and Challenges

Yanmin Zhu, Yuxing Li, Jianqing Huang, Yunping Zhang, Yuen‐Wa Ho, James Kar‐Hei Fang and Edmund Y. Lam

Advanced Photonics Research, 2024, 5
DOI: 10.1002/adpr.202400038

Determination of carbon in microplastics and single cells by total consumption microdroplet ICP-TOFMS

Thomas Vonderach, Alexander Gundlach-Graham and Detlef Günther

Anal Bioanal Chem, 2024, 416, 2773
DOI: 10.1007/s00216-023-05064-0

Single-Particle ICP-TOFMS with Online Microdroplet Calibration: A Versatile Approach for Accurate Quantification of Nanoparticles, Submicron Particles, and Microplastics in Seawater

Stasia Harycki and Alexander Gundlach-Graham

Anal. Chem., 2023, 95, 15318
DOI: 10.1021/acs.analchem.3c02785

Single-Cell/Particle Sample Introduction Device for Mass Cytometry Based on Gas-Driven Flow Focusing

Huaiyi Chen, Jinhui Liu, Yu Zhao, Haitao Xu, Weiliang Liu, Zhi Xing, Fei Tang, Sichun Zhang and Xinrong Zhang

Anal. Chem., 2025, 97, 4590
DOI: 10.1021/acs.analchem.4c06466

Single Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry—A Powerful Tool for the Analysis of Nanoparticles in the Environment

Ziwei Meng, Lingna Zheng, Hao Fang, Pu Yang, Bing Wang, Liang Li, Meng Wang and Weiyue Feng

Processes, 2023, 11, 1237
DOI: 10.3390/pr11041237

Rapid isotopic analysis of uranium microparticles via SP-ICP-TOF-MS

Jordan S. Stanberry, Sarah E. Szakas, Hunter B. Andrews, Lyndsey Hendriks, Brian W. Ticknor, Rachel A. Bergin, Shawna K. Tazik, Philip Kegler, Stefan Neumeier, N. Alex Zirakparvar, Daniel R. Dunlap and Benjamin T. Manard

Talanta, 2026, 297, 128578
DOI: 10.1016/j.talanta.2025.128578

High-throughput single-cell analysis of nanoparticle-cell interactions

Majood Haddad, Alex N. Frickenstein and Stefan Wilhelm

TrAC Trends in Analytical Chemistry, 2023, 166, 117172
DOI: 10.1016/j.trac.2023.117172

Direct Measurement of Microplastics by Carbon Detection via Single Particle ICP-TOFMS in Complex Aqueous Suspensions

Lyndsey Hendriks and Denise M. Mitrano

Environ. Sci. Technol., 2023, 57, 7263
DOI: 10.1021/acs.est.3c01192

Capabilities of simultaneous 193 nm - LIBS/LA-ICP-MS imaging for microplastics characterization

Lukas Brunnbauer, Mara Jirku, C Derrick Quarles and Andreas Limbeck

Talanta, 2024, 269, 125500
DOI: 10.1016/j.talanta.2023.125500

Recent Applications in Analytical Techniques of Microplastics

Meng Zhang, Jinhang Pan, Daqian Song, Jie Jiang and Yanxiao Jiang

Critical Reviews in Analytical Chemistry, 2025, 1
DOI: 10.1080/10408347.2025.2518328

Potential health, environmental implication of microplastics: A review on its detection

Bhawana Yadav, Payal Gupta, Vinay Kumar, Mridul Umesh, Deepak Sharma, Jithin Thomas and Suraj Kumar Bhagat

Journal of Contaminant Hydrology, 2025, 268, 104467
DOI: 10.1016/j.jconhyd.2024.104467

Characterization and Quantification of Natural and Anthropogenic Titanium-Containing Particles Using Single-Particle ICP-TOFMS

Hark Karkee and Alexander Gundlach-Graham

Environ. Sci. Technol., 2023, 57, 14058
DOI: 10.1021/acs.est.3c04473

The emerging field of inductively coupled plasma mass spectrometry for (micro)nanoplastic analysis: “The 3As” analysis, advances, and applications

Gurusamy Kutralam-Muniasamy, V.C. Shruti, Fermín Pérez-Guevara and Joel Alba Flores

TrAC Trends in Analytical Chemistry, 2024, 174, 117673
DOI: 10.1016/j.trac.2024.117673

Particle Size Measurement and Detection of Bound Proteins of Non-Porous/Mesoporous Silica Microspheres by Single-Particle Inductively Coupled Plasma Mass Spectrometry

Shin-ichi Miyashita, Toshihiko Ogura, Shun-ichi Matsuura and Eriko Fukuda

Molecules, 2024, 29, 1086
DOI: 10.3390/molecules29051086

Single-Particle ICP-TOFMS Analysis of Aerosol Particulate Matter Released by Fused Deposition Modeling 3D Printers

Tristen L. Taylor, Madison Strait and Alexander Gundlach-Graham

Anal. Chem., 2024, 96, 20535
DOI: 10.1021/acs.analchem.4c04937

Elemental and isotopic analyses of individual nanoparticles using single particle inductively coupled plasma mass spectrometry

Masaki Nakazato and Takafumi Hirata

ANAL. SCI., 2025, 41, 1185
DOI: 10.1007/s44211-025-00766-0

Inductively coupled plasma mass spectrometry

Thibaut Van Acker, Sarah Theiner, Eduardo Bolea-Fernandez, Frank Vanhaecke and Gunda Koellensperger

Nat Rev Methods Primers, 2023, 3
DOI: 10.1038/s43586-023-00235-w

Wildfire induced release of Cr nanoparticles from Tire Crumb Rubber

Carmen M. Villarruel, Aaron Goodman, Hark Karkee, Heather Lowers, Jay Thompson, Alexander Gundlach-Graham and James F. Ranville

Journal of Hazardous Materials, 2025, 495, 138880
DOI: 10.1016/j.jhazmat.2025.138880

Single Cell–ICP–ToF-MS for the Multiplexed Determination of Proteins: Evaluation of the Cellular Stress Response

Paula Menero-Valdés, Michail I. Chronakis, Beatriz Fernández, C. Derrick Quarles, Héctor González-Iglesias, Björn Meermann and Rosario Pereiro

Anal. Chem., 2023, 95, 13322
DOI: 10.1021/acs.analchem.3c02558