Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

Diana V. Silva-Brenes, Shailesh Agrawal, Vilmalí López-Mejías, Jorge Duconge, Cornelis P. Vlaar, Jean-Christophe M. Monbaliu and Torsten Stelzer

React. Chem. Eng., 2024, 9, 2728
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A novel technique for determining the distribution of impurities in crystals during cooling crystallization

Yiting Xiao, Zhengbin Pan, Peichi Duan, Jiayou Yuan and Bo Kong

CrystEngComm, 2024, 26, 3455
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Impurity retention and pharmaceutical solid solutions: visualizing the effect of impurities on dissolution and growth using dyed crystals

Anne Nong, Claire Schleper, Abigail Martin, Mitchell Paolello, Fredrik L. Nordstrom and Gerard Capellades

CrystEngComm, 2024, 26, 5337
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Ultrasound mechanisms and their effect on solid synthesis and processing: a review

Cedric Devos, Ariana Bampouli, Elena Brozzi, Georgios D. Stefanidis, Michiel Dusselier, Tom Van Gerven and Simon Kuhn

Chem. Soc. Rev., 2025, 54, 85
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Microscopic kinetic model of gas hydrate and the effect of brine: a case study of natural gas hydrate from the seabed off the Tokachi coast

Satoshi Takeya, Kiyofumi Suzuki, Akihiro Hachikubo, Hirotoshi Sakagami, Hirotsugu Minami, Satoshi Yamashita, Keiichi Hirano, Kazuyuki Hyodo, Masahide Kawamoto and Akio Yoneyama

CrystEngComm, 2025, 27, 695
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Unveiling the GeI2‐Assisted Oriented Growth of Perovskite Crystallite for High‐Performance Flexible Sn Perovskite Solar Cells

Huagui Lai, Selina Olthof, Shengqiang Ren, Radha K. Kothandaraman, Matthias Diethelm, Quentin Jeangros, Roland Hany, Ayodhya N. Tiwari, Dewei Zhao and Fan Fu

Energy & Environ Materials, 2025, 8
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Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development

Paridhi Agrawal, Saurin H. Rawal, Venkata Ramana Reddy, Shekhar K. Viswanath and Jeremy M. Merritt

Org. Process Res. Dev., 2023, 27, 610
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Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations

Fredrik L. Nordstrom, Eric Sirota, Clara Hartmanshenn, Thomas T. Kwok, Mitchell Paolello, Huayu Li, Vincent Abeyta, Tommasina Bramante, Emma Madrigal, Taylor Behre and Gerard Capellades

Org. Process Res. Dev., 2023, 27, 723
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Water crystallization process and kinetics

Jianfeng Wan, Tianen Li, Wenyan Bi, Yikai Hou, Menglin Yu, Yihong Sun, Shizheng Xie, Dongkui Zhou and Weijie Li

Molecular Crystals and Liquid Crystals, 2025, 1
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Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction

Brittany M. Armstrong, Taylor Behre, Ben W. H. Turnbull, Daniel Bishara, Clara Hartmanshenn, Erin McCarthy, Michael Whittington, Yining Ji, Anna Jenks, Richard Desmond, Daniel J. Muzzio, James Corry, Ralph Zhao, Nadine Kuhl and Cheol K. Chung

Org. Process Res. Dev., 2023, 27, 763
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Focusing Impurities during Inert Gassing Crystallization of Complex Mixtures

Astrid I. Seifert, Anna Wehning, Jan Gutsch and Kerstin Wohlgemuth

Org. Process Res. Dev., 2023, 27, 1485
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Breaking separation bottleneck in sucralose production: Clarifying the obscure mechanism and pre-embedding second solvents for highly selective separation of chlorinated product

Xiaoping Chen, Jiayan Lei, Zhoulin Lv, Zi'ang Chen, Shitong Lin, Zhenming Guo, Huadong Luo, Yingshu Wang, Jingjing Chen, Haohong Li and Huidong Zheng

Chemical Engineering Journal, 2025, 504, 158949
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Nanoscale Crystal Growth Processes Triggered by Captured Solid Impurity Particles

Natalia Nikolaevna Piskunova

SSRN Journal, 2022
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Control of crystal nucleation, size and morphology using micro−/nanobubbles as green additives – a review

Isaac D. Tegladza, Guihong Lin, Chang Liu and Xuehong Gu

Separation and Purification Technology, 2023, 311, 123232
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Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization – Part 2: Industrial Case Studies

Fredrik L. Nordstrom, Mitchell Paolello, Na Yao, Travis Armiger, Qi Jiang, James Nicholson, Joseph Kratz, Michael Toresco, Alexander Lipp, Swjatoslaw Witte, Manuel Henry, C. Scott Shultz, Eric Sirota and Gerard Capellades

Org. Process Res. Dev., 2024, 28, 388
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Nanoscale crystal growth processes triggered by captured solid impurity particles

Natalia N. Piskunova

Journal of Crystal Growth, 2023, 603, 127013
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Comparison of the Effects of Crystalline Particle Size Modified by Crystallization on the Mother Liquor Removal Profiles of Washing and Reslurry

Ryota Miyamoto, Shuntaro Amari and Hiroshi Takiyama

Journal of Chemical Engineering of Japan, 2023, 56
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Study of the Effects of Different Factors on Crystal Growth from Solution: Data of Atomic Force Microscopy

N. N. Piskunova

Geochem. Int., 2024, 62, 634
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Effects of Properties of Crystalline Particles on Mother Liquor Holdup in Crystal Cake and Residue Behaviors of Impurities

Ryota Miyamoto, Shuntaro Amari and Hiroshi Takiyama

Journal of Chemical Engineering of Japan, 2023, 56
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Real-Time Optimization and Genetic Algorithm for Enhanced Process Control of Coupling Cooling and Antisolvent Crystallization

Shutian XuanYuan, Ying Sun, Xiaomeng Zhou, Yunhe Bai, Yang Ye, Cuihong Hu, Hongxun Hao and Chuang Xie

Ind. Eng. Chem. Res., 2025, 64, 2199
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Controlling Energetic Crystal Morphology Using Tailored Polymeric Additives

Shelby T. Nicolau and Adam J. Matzger

Crystal Growth & Design, 2025, 25, 1667
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Modeling of the Crystallization Conditions for Organic Synthesis Product Purification Using Deep Learning

Mantas Vaškevičius, Jurgita Kapočiūtė-Dzikienė and Liudas Šlepikas

Electronics, 2022, 11, 1360
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Continuous crystallization and its potential use in drug substance Manufacture: A review

Ayse Eren, Francesco Civati, Wenchuan Ma, Janaka C. Gamekkanda and Allan S. Myerson

Journal of Crystal Growth, 2023, 601, 126958
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In-situ microscopic observation of single-crystal diamond during chemical vapor deposition

Kaishu Nitta, Takehiro Shimaoka, Hideaki Yamada, Nobuteru Tsubouchi, Akiyoshi Chayahara and Yoshiaki Mokuno

Diamond and Related Materials, 2025, 154, 112154
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Effects of structure similar additive on the crystallization of L-phenylalanine from aqueous solution

Yan Li, Shan Ling, Xujiao Gao, Lin Cheng, Kai Li and Xingang Li

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 703, 135364
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Unveiling the potential of metal-organic framework-based membranes: Transforming material science for a sustainable future

Mohamed Abboud, Abdelkarim Chaouiki, Maryam Chafiq, Siti Fatimah, Noureddine Elboughdiri, Jee-Hyun Kang and Young Gun Ko

Separation and Purification Technology, 2025, 361, 131332
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Growth of broken crystals tracked in 4D using X-ray computed tomography and its influence on impurity incorporation

S. A. Schiele, T. Haider and H. Briesen

Sci Rep, 2024, 14
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Microelectron Diffraction Reveals Contamination of Polymorphs by Structure Analysis of Microscale Crystals in a Novel Pharmaceutical Cocrystal

Tetsuya Miyano, Yuya Hirakawa, Akihito Yamano and Hiroshi Ueda

Crystal Growth & Design, 2023, 23, 7706
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Use of automation, dynamic image analysis, and process analytical technologies to enable data rich particle engineering efforts at the Drug Substance / Drug Product interface: A case study using Lovastatin

Shailesh Agrawal, Saurin H. Rawal, Venkata Ramana Reddy and Jeremy M. Merritt

Chemical Engineering Research and Design, 2024, 205, 578
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Unveiling the solvent effects on the solubility of 2-Amyl Anthraquinone in eleven single solvents

Hongmei Zhang, Xudong Zhang, Hongyu Miao, Minna Liu, Mingdong Zhou and Yu Liu

Journal of Molecular Liquids, 2025, 424, 127079
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The Solubility of Ethyl Candesartan in Mono Solvents and Investigation of Intermolecular Interactions

Cunbin Du

Liquids, 2022, 2, 404
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Scale-Up and Postapproval Changes in Orally Inhaled Drug Products: Scientific and Regulatory Considerations

Gur Jai Pal Singh and S. Prasad Peri

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2025, 38, 39
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Inert Gassing Crystallization for Improved Product Separation of Oleo-Chemicals toward an Efficient Circular Economy

Astrid I. Seifert, Justin Simons, Jan Gutsch and Kerstin Wohlgemuth

Org. Process Res. Dev., 2023, 27, 136
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Sensitizing Explosives Through Molecular Doping

Shelby T. Nicolau and Adam J. Matzger

ChemPlusChem, 2024, 89
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A changing paradigm in industrial pharmaceutical crystallization

Stefani Kocevska, Christopher L. Burcham, Fredrik Nordstrom and Giovanni Maria Maggioni

Nat Chem Eng, 2024, 1, 327
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Enhancement of Hydrate Stability through Substitutional Defects

Megan E. Fleming and Jennifer A. Swift

Crystal Growth & Design, 2023, 23, 5860
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Probing the Molecular and Macroscopic Structure of Solid Solutions by Dynamic Nuclear Polarization (DNP) Enhanced 13C and 15N Solid-State NMR Spectroscopy

Jiashan Mi, Yunhua Chen, Benjamin A. Atterberry, Fredrik L. Nordstrom, David A. Hirsh and Aaron J. Rossini

Mol. Pharmaceutics, 2024, 21, 2949
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Novel twisted hexagonal tubular crystallizer used for thiourea cooling crystallization: Improving crystal qualities

Tong Zhou, Xueke Wang, Zhongxiang Ding, Tuo Ji, Xin Feng and Changsong Wang

Powder Technology, 2024, 447, 120217
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NaCl Crystals as Carriers for Micronutrient Delivery

Simon E. G. Lepinay, Raymond Nijveld, Krassimir P. Velikov and Noushine Shahidzadeh

ACS Omega, 2022, 7, 28955
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Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection

Fredrik L. Nordstrom, Mitchell Paolello, Na Yao, Travis Armiger, Qi Jiang, James Nicholson, Joseph Kratz, Michael Toresco, Alexander Lipp, Swjatoslaw Witte, Manuel Henry, C. Scott Shultz, Eric Sirota and Gerard Capellades

Org. Process Res. Dev., 2024, 28, 367
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Mathematical Modeling and Optimization to Inform Impurity Control in an Industrial Active Pharmaceutical Ingredient Manufacturing Process

Samir Diab, Charalampos Christodoulou, George Taylor and Philip Rushworth

Org. Process Res. Dev., 2022, 26, 2864
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Study of the Effects of Different Factors on Crystal Growth from Solution: Data of Atomic Force Microscopy

N. N. Piskunova

Geohimiâ, 2024, 69, 535
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Kinetic Optimization of the Batch Crystallization of an Active Pharmaceutical Ingredient in the Presence of a Low-Solubility, Precipitating Impurity

Mitchell Paolello, Ilyes Bichari, Davinia Brouckaert, Mirvatte Francis, Dawn Yang and Gerard Capellades

Crystals, 2023, 13, 1569
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