Review on mechanisms of hypoglycemic effects of compounds from highland barley and potential applications

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Food Funct., 2024, 15, 11365
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6,8-(1,3-Diaminoguanidine) luteolin and its Cr complex show hypoglycemic activities and alter intestinal microbiota composition in type 2 diabetes mice

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Food Funct., 2022, 13, 3572
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Porous starch microspheres loaded with luteolin exhibit hypoglycemic activities and alter gut microbial communities in type 2 diabetes mellitus mice

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Food Funct., 2025, 16, 54
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Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber

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Food Funct., 2022, 13, 2710
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Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

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Food Funct., 2022, 13, 11758
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Effects of jabuticaba, a Brazilian berry, on obesity, metabolic parameters, and gut health in high-fat diet animal models: a systematic review

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Food Funct., 2026, 17, 1145
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Heat-treated foxtail millet protein delayed the development of pre-diabetes to diabetes in mice by altering gut microbiota and metabolomic profiles

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Food Funct., 2023, 14, 4866
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Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice

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Food Funct., 2023, 14, 8487
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Studies on the inhibition mechanism of α-glucosidase by kaempferide: Enzyme kinetic, multi-spectroscopy and molecular docking techniques

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Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins alleviate insulin-resistance via activating PI3K/AKT pathway in HepG2 cells

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Journal of Functional Foods, 2022, 99, 105297
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(-)-Epicatechin and β-glucan from highland barley grain modulated glucose metabolism and showed synergistic effect via Akt pathway

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Journal of Functional Foods, 2021, 87, 104793
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Synthesis and Characterization of Ficus carica Polysaccharide-Gold Nanoparticles for Enhanced Antidiabetic Activity

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Journal of Future Foods, 2026
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Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents

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Whole-grain highland barley premade biscuit prepared by hot-extrusion 3D printing: Printability and nutritional assessment

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Food Chemistry, 2024, 432, 137226
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Fermented Rice Germ Extract Ameliorates Abnormal Glucose Metabolism via Antioxidant Activity in Type 2 Diabetes Mellitus Mice

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Applied Sciences, 2021, 11, 3091
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MicroRNA-mediated mechanisms in whole grain consumption for preventing type 2 diabetes mellitus

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Trends in Food Science & Technology, 2024, 153, 104745
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Schisandra sphenanthera extract modulates sweet taste receptor pathway, IRS/PI3K, AMPK/mTOR pathway and endogenous metabolites against T2DM

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Phenolic Compounds in Cereals: Advances and Challenges in the Extraction, Detection, and Health Implications

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Food Reviews International, 2025, 1
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The induced-fit and catalytic mechanisms of human G6PC1

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Steamed Multigrain Bread Prepared from Dough Fermented with Lactic Acid Bacteria and Its Effect on Type 2 Diabetes

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Foods, 2023, 12, 2319
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Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder

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Ferulic Acid Mediates Metabolic Syndrome via the Regulation of Hepatic Glucose and Lipid Metabolisms and the Insulin/IGF-1 Receptor/PI3K/AKT Pathway in Palmitate-Treated HepG2 Cells

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J. Agric. Food Chem., 2022, 70, 14706
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Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio) fed with a high-starch diet

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Front. Mol. Biosci., 2023, 10
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Fecal microbiota transplantation: whole grain highland barley improves glucose metabolism by changing gut microbiota

Xin Ren, Fulong Zhang, Min Zhang, Yuan Fang, Zenglong Chen and Meili Huan

Food Science and Human Wellness, 2024, 13, 2014
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Refined highland barley ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and liver transcriptomics

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Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota

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Food Bioscience, 2022, 50, 101946
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Traditional Chinese medicine for treatment of type 2 diabetes mellitus: Clinical evidence and pharmacological mechanisms

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Journal of Integrative Medicine, 2025, 23, 605
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Highland Barley Alleviates High-Fat Diet-Induced Obesity and Liver Injury Through the IRS2/PI3K/AKT Signaling Pathway in Rats

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Nutrients, 2024, 16, 3518
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Korean naked waxy barley (saechalssal) extract reduces blood glucose in diabetic mice by modulating the PI3K-Akt-GSK3β pathway

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Biomedicine & Pharmacotherapy, 2022, 150, 112976
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The Antioxidant Properties, Metabolism, Application and Mechanism of Ferulic Acid in Medicine, Food, Cosmetics, Livestock and Poultry

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Antioxidants, 2024, 13, 853
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Nutrigenomics in exercise science: interactions between gene, diet, and exercise

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Food Science and Human Wellness, 2025, 14, 9250529
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Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p

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Synthesis of new chalcones and pyrimidine derivatives as antidiabetic agents for type 2 diabetes mellitus: In vitro and in vivo studies

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Bioorganic Chemistry, 2025, 163, 108696
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A New Perspective on Signaling Pathways and Structure–Activity Relationships of Natural Active Ingredients in Metabolic Crosstalk Between Liver and Brown Adipose Tissue: A Narrative Review

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Phytotherapy Research, 2025, 39, 3062
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Modulation Effects of Sargassum pallidum Extract on Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice

Xing Xie, Chun Chen and Xiong Fu

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Improvement of glucose metabolism disorder by wheat dietary fibre depended on the intake mode and regulated through TLRs/NF-κB/TNF pathway in db/db mice

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Food and Agricultural Immunology, 2024, 35
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Yao-Shan of traditional Chinese medicine: an old story for metabolic health

Shuangling Yang, Hongzhi Yang and Yaxing Zhang

Front. Pharmacol., 2023, 14
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Beneficial Effects of Partly Milled Highland Barley on the Prevention of High-Fat Diet-Induced Glycometabolic Disorder and the Modulation of Gut Microbiota in Mice

Siqi Li, Mengqian Wang, Chang Li, Qingjia Meng, Yantong Meng, Jian Ying, Shuqun Bai, Qun Shen and Yong Xue

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PACAP ameliorates obesity‐induced insulin resistance through FAIM/Rictor/AKT axis

Jia Feng, Wenhui Chen, Shanshan Li, Qianchen Fang, Xingwu Chen, Ge Bai, Meng Tian, Yongmei Huang, Pei Xu, Zixian Wang and Yi Ma

The FEBS Journal, 2024
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Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice

Zehua Liu, Zhaowan Zhang, Ruoxin Tang, Jianshen Liu and Yijie Yang

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Isobavachalcone Inhibits Hyperglycemia and Hyperlipemia in Type 2 Diabetes and the Underlying Mechanisms

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Hypermethylation of the Promoter of miR-338-5p Mediates Aberrant Expression of ETS-1 and Is Correlated With Disease Severity Of Astrocytoma Patients

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Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome

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Revealing the potential hypoglycaemic ingredients of Terminalia chebula Retz. by spectrum–effect relationship combining molecular docking and experimental validation

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T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

Yang Yang, Ma Yue, Han Jing, Peng Weijia, Pi Rongbiao, Yang Bo, Zhu Zeyu and Akhilesh K. Verma

Journal of Food Biochemistry, 2023, 2023, 1
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Antihyperglycemic effects of triterpenoid saponins from the seeds of Bge

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Exploration of the molecular mechanism of Polygonati Rhizoma in the treatment of hyperlipidemia based on network pharmacology and molecular docking

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Procyanidin B1 and p‐Coumaric Acid from Highland Barley Grain Showed Synergistic Effect on Modulating Glucose Metabolism via IRS‐1/PI3K/Akt Pathway

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Bovine Pre-adipocyte Adipogenesis Is Regulated by bta-miR-150 Through mTOR Signaling

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Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs

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Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals

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Hypoglycemic effect and intestinal transport of phenolics-rich extract from digested mulberry leaves in Caco-2/insulin-resistant HepG2 co-culture model

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Anti-Diabetic Activity of Heuksoojeongchal Bran Prethanol Extract in HFD/STZ-Induced Diabetic Mice

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JKFN, 2021, 50, 655
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Hyperglycemia symptom amelioration by Ascophyllum nodosum polysaccharides in mice with type 2 diabetes

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Bioactive compounds of highland barley and their health benefits

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Recent advances of Sargassum pallidum in chemical and biological aspects

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Front. Pharmacol., 2025, 16
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Integrated metabolomic and transcriptome analyses reveal the regulatory mechanisms of partridge tea phenolics-rich extracts on type 2 diabetes mice

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Metformin: Expanding the Scope of Application—Starting Earlier than Yesterday, Canceling Later

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Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells

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Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives

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Whole Grain Proso Millet (Panicum miliaceum L.) Attenuates Hyperglycemia in Type 2 Diabetic Mice: Involvement of miRNA Profile

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Effects of physical activity on cell‐to‐cell communication during type 2 diabetes: A focus on miRNA signaling

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Based on network pharmacology to explore the effect and mechanism of Yipibushen decoction in improving obese type 2 diabetes mellitus with oligoasthenotspermia

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Involvement of intestinal flora and miRNA into the mechanism of coarse grains improving type 2 diabetes: an overview

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Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K / AKT signaling pathway in high‐fat diet and streptozotocin‐induced diabetic mice

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