A multifunctional polymeric coating with self-adsorbed, antifouling and in situ remineralization properties for caries management

Wenlin Chu, Haiqin Tang, Zhiyun Dong, Ailin Hou, Rongmin Qiu, Xinyuan Xu, Jiaojiao Yang, Libang He, Jun Luo and Jianshu Li

J. Mater. Chem. B, 2023, 11, 5151
DOI: 10.1039/D3TB00377A

A bioactive poly(ether-ether-ketone) nanocomposite scaffold regulates osteoblast/osteoclast activity for the regeneration of osteoporotic bone

Mengen Zhao, Guo Chen, Shixiong Zhang, Bin Chen, Zhaoying Wu and Chao Zhang

J. Mater. Chem. B, 2022, 10, 8719
DOI: 10.1039/D2TB01387H

Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis

Xinyi Dong, Hao Liu, Dian Yuan, Karan Gulati and Yan Liu

J. Mater. Chem. B, 2025, 13, 4938
DOI: 10.1039/D4TB02628D

Reinforcement of PVA in a gadolinium-doped 45S5 bioglass-capped chitosan hydrogel with superior magnetic resonance contrast and osteogenic and angiogenic features

Deepa Murugan, Hariharan Arumugam, Abhishek Kumar, Arunkumar Dhayalan and S. Kannan

New J. Chem., 2025
DOI: 10.1039/D5NJ02414E

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Pengfei Zhang, Jin Qi, Ran Zhang, Yifan Zhao, Jingyu Yan, Yajuan Gong, Xiaoming Liu, Binbin Zhang, Xiao Wu, Xiuping Wu, Cheng Zhang, Bing Zhao and Bing Li

Biomater. Sci., 2024, 12, 308
DOI: 10.1039/D3BM01795H

Bone/cartilage targeted hydrogel: Strategies and applications

Hao Zhang, Shunli Wu, Weikai Chen, Yan Hu, Zhen Geng and Jiacan Su

Bioactive Materials, 2023, 23, 156
DOI: 10.1016/j.bioactmat.2022.10.028

Addressing the Osteoporosis Problem—Multifunctional Injectable Hybrid Materials for Controlling Local Bone Tissue Remodeling

Adriana Gilarska, Alicja Hinz, Monika Bzowska, Grzegorz Dyduch, Kamil Kamiński, Maria Nowakowska and Joanna Lewandowska-Łańcucka

ACS Appl. Mater. Interfaces, 2021, 13, 49762
DOI: 10.1021/acsami.1c17472

A Novel Formulation of Hydrogel Incorporated with Alendronate to Enhance Bone Regeneration: Synthesis, Characterization and In Vitro Study Using Human Osteoblast-Like Cells (Saos2 Cell Line)

Shiyang Chen, Shilpa Perumal Narasimhamoorthi, Palanisamy Arulselvan and Xueqiang Qi

J Inorg Organomet Polym, 2025
DOI: 10.1007/s10904-025-03931-0

Overview of Polyethylene Glycol-based Materials with a Special Focus on Core-Shell Particles for Drug Delivery Application

Nasrullah Shah, Manzoor Hussain, Touseef Rehan, Abbas Khan and Zubair Ullah Khan

CPD, 2022, 28, 352
DOI: 10.2174/1381612827666210910104333

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Xiao Wang, Jia Zeng, Donglin Gan, Kun Ling, Mingfang He, Jianshu Li and Yongping Lu

Nano-Micro Lett., 2025, 17
DOI: 10.1007/s40820-024-01557-4

Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

Guoke Tang, Bingyan Zhou, Feng Li, Weiheng Wang, Yi Liu, Xing Wang, Chao Liu and Xiaojian Ye

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00745

Current Trends of Targeted Drug Delivery for Oral Cancer Therapy

Mingming Zhang, Jianqin Liang, Yanyu Yang, Huize Liang, Huaping Jia and Dawei Li

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.618931

Robust, anti-freezing and conductive bonding of chitosan-based double-network hydrogels for stable-performance flexible electronic

Yanyu Yang, Manhua Zhou, Junbo Peng, Xing Wang, Yang Liu, Wanjie Wang and Decheng Wu

Carbohydrate Polymers, 2022, 276, 118753
DOI: 10.1016/j.carbpol.2021.118753

Towards Controlling the Local Bone Tissue Remodeling—Multifunctional Injectable Composites for Osteoporosis Treatment

Joanna Klara, Sylwia Onak, Andrzej Kowalczyk, Wojciech Horak, Kinga Wójcik and Joanna Lewandowska-Łańcucka

IJMS, 2023, 24, 4959
DOI: 10.3390/ijms24054959

Current Status of the Diagnosis and Management of Osteoporosis

Agustín Aibar-Almazán, Ana Voltes-Martínez, Yolanda Castellote-Caballero, Diego Fernando Afanador-Restrepo, María del Carmen Carcelén-Fraile and Elena López-Ruiz

IJMS, 2022, 23, 9465
DOI: 10.3390/ijms23169465

Biotesting of titanium tetrapolyethylene glycolate in 10 molar excess on granulosa cell culture of porcine follicles

A. O. Prituzhalova, T. I. Kuzmina, T. G. Khonina and U. S. Nikulina

Аграрная наука Евро-Северо-Востока, 2024, 25, 920
DOI: 10.30766/2072-9081.2024.25.5.920-929

Advances in materials-based therapeutic strategies against osteoporosis

Chen Lei, Jing-han Song, Song Li, Yi-na Zhu, Ming-yi Liu, Mei-chen Wan, Zhao Mu, Franklin R. Tay and Li-na Niu

Biomaterials, 2023, 296, 122066
DOI: 10.1016/j.biomaterials.2023.122066

Three-Dimensional Bioprinting for Intervertebral Disc Regeneration

Md Amit Hasan Tanvir, Md Abdul Khaleque, Junhee Lee, Jong-Beom Park, Ga-Hyun Kim, Hwan-Hee Lee and Young-Yul Kim

JFB, 2025, 16, 105
DOI: 10.3390/jfb16030105

Cascade Reaction of Thiol–Disulfide Exchange Potentiates Rapid Fabrication of Polymer Hydrogels

Peiyu Zhang, Ning Wang, Dandan Ren, Zongyu Jing, Kanaparedu P. C. Sekhar, Jingcheng Hao and Jiwei Cui

ACS Macro Lett., 2023, 12, 1437
DOI: 10.1021/acsmacrolett.3c00482

Alendronate-decorated strontium-containing bioactive glass nanoparticles with dual osteogenic and anti-osteoclastic effects for osteoporosis

Mengen Zhao, Chao Zhang, Chenyu Gao and Zhaoying Wu

Journal of Non-Crystalline Solids, 2023, 622, 122681
DOI: 10.1016/j.jnoncrysol.2023.122681

Bioactive composite hydrogel with effects of robust promoting osteogenesis and immunomodulation for osteoporotic bone regeneration

Bin Sun, Hufei Wang, Bing Xiao, Huichun Yan, Huiqiao Wu, Rongcheng Zhang, Ying Zhang, Wen Yuan, Xing Wang and Changgui Shi

Chemical Engineering Journal, 2023, 476, 146743
DOI: 10.1016/j.cej.2023.146743

Alendronate-functionalized double network hydrogel scaffolds for effective osteogenesis

Guoke Tang, Liang Zhu, Weiheng Wang, Dongqing Zuo, Changgui Shi, Xiaojie Yu and Rui Chen

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.977419

Engineered Dynamic Hydrogel Niches for the Regulation of Redox Homeostasis in Osteoporosis and Degenerative Endocrine Diseases

Weihao Yuan, Jiankun Xu, Na Yang, Han Wang, Jinteng Li, Mengyao Zhang and Meiling Zhu

Gels, 2023, 10, 31
DOI: 10.3390/gels10010031

Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1

Weilin Zhang, Hongrui Rong, Jinguo Liang, Chao Mao, Zhencong Li, Zhiwen Dai, Dingbin Li, Weixiong Guo, Siyuan Chen, Zhongwei Wang and Jinsong Wei

J Biol Eng, 2024, 18
DOI: 10.1186/s13036-024-00422-7

Bioinspired injectable hydrogels for bone regeneration

Xuan Tang, Fengjin Zhou, Sicheng Wang, Guangchao Wang, Long Bai and Jiacan Su

Journal of Advanced Research, 2024
DOI: 10.1016/j.jare.2024.10.032

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Dawei Li, Jing Chen, Xing Wang, Mingming Zhang, Chunlin Li and Jin Zhou

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00926

Fabrication of an injectable hydrogel scaffold embedding kartogenin-encapsulated PLGA microsphere with long-term drug release to promote chondrogenesis

Wei Zhang, Guoke Tang, Baoyu Zhu, Meijun Yan, Fangyuan Yu, Xing Wang and Bin Yu

Reactive and Functional Polymers, 2024, 196, 105821
DOI: 10.1016/j.reactfunctpolym.2023.105821

Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation

Tingting Yu, Lingyun Zhang, Xueyu Dou, Rushui Bai, Hufei Wang, Jie Deng, Yunfan Zhang, Qiannan Sun, Qian Li, Xing Wang and Bing Han

Advanced Science, 2022, 9
DOI: 10.1002/advs.202203734

How Efficient are Alendronate-Nano/Biomaterial Combinations for Anti-Osteoporosis Therapy? An Evidence-Based Review of the Literature

Joanna Klara and Joanna Lewandowska-Łańcucka

IJN, 2022, Volume 17, 6065
DOI: 10.2147/IJN.S388430

An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation

Tao Yu, Yunping Hu, Wenbao He, Yong Xu, Anqi Zhan, Kai Chen, Mingxiang Liu, Xiufeng Xiao, Xiangyang Xu, Qian Feng and Liangfu Jiang

Materials Today Bio, 2023, 19, 100558
DOI: 10.1016/j.mtbio.2023.100558

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Shouye Sun, Yutao Cui, Baoming Yuan, Minghan Dou, Gan Wang, Hang Xu, Jingwei Wang, Wen Yin, Dankai Wu and Chuangang Peng

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1117647

Enhanced osteogenic differentiation of alendronate-conjugated nanodiamonds for potential osteoporosis treatment

Guk Young Ahn, Sung-Eun Kim, Tae Hoon Yun, Inseong Choi, Daewon Park and Sung-Wook Choi

Biomater Res, 2021, 25
DOI: 10.1186/s40824-021-00231-9

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

Daoyang Fan, Qi Wang, Tengjiao Zhu, Hufei Wang, Bingchuan Liu, Yifan Wang, Zhongjun Liu, Xunyong Liu, Dongwei Fan and Xing Wang

Front. Chem., 2020, 8
DOI: 10.3389/fchem.2020.00745

Facile Construction of Hybrid Hydrogels with High Strength and Biocompatibility for Cranial Bone Regeneration

Shuai Chang, Jiedong Wang, Nanfang Xu, Shaobo Wang, Hong Cai, Zhongjun Liu and Xing Wang

Gels, 2022, 8, 745
DOI: 10.3390/gels8110745

Biofabrication Approaches for Peri-Implantitis Tissue Regeneration: A Focus on Bioprinting Methods

Dobromira Shopova, Anna Mihaylova, Antoniya Yaneva, Desislava Bakova and Mariana Dimova-Gabrovska

Prosthesis, 2024, 6, 372
DOI: 10.3390/prosthesis6020028

Prodrug approaches for the development of a long-acting drug delivery systems

Shin-Tian Chien, Ian T. Suydam and Kim A. Woodrow

Advanced Drug Delivery Reviews, 2023, 198, 114860
DOI: 10.1016/j.addr.2023.114860

A sustained release of alendronate from an injectable tetra-PEG hydrogel for efficient bone repair

Shuai Chang, Chao Li, Nanfang Xu, Jiedong Wang, Zehao Jing, Hong Cai, Yun Tian, Shaobo Wang, Zhongjun Liu and Xing Wang

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.961227

Material‐Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair

Pengfei Xue, Jiayi Wang, Yu Fu, Hongyan He, Qi Gan and Changsheng Liu

Small, 2025, 21
DOI: 10.1002/smll.202409886

Polyhedral Oligomeric Silsesquioxanes (POSS)‐based Hybrid Materials: Molecular Design, Solution Self‐Assembly and Biomedical Applications

Linfeng Fan, Xing Wang and Decheng Wu

Chin. J. Chem., 2021, 39, 757
DOI: 10.1002/cjoc.202000536

Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Chunlan Jing, Shenmao Chen, Sehajdev Singh Bhatia, Bowen Li, Hongze Liang, Chaozong Liu, Zhenjiang Liang, Junying Liu, Haiyan Li, Ziyu Liu, Hui Tan and Lingling Zhao

Polymer Testing, 2022, 110, 107584
DOI: 10.1016/j.polymertesting.2022.107584

Functional Hydrogel Interfaces for Cartilage and Bone Regeneration

Yucheng Cao, Changyi Liu, Wenjun Ye, Tianrui Zhao and Fanfan Fu

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202403079

Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer

Yingning He, Yue Yu, Yuqian Yang, Yexin Gu, Tianjiao Mao, Yang Shen, Qiong Liu, Ruili Liu and Jiandong Ding

Bioactive Materials, 2022, 15, 288
DOI: 10.1016/j.bioactmat.2021.12.010

Advances of Hydrogel-Based Bioprinting for Cartilage Tissue Engineering

Xue Han, Shuai Chang, Mingming Zhang, Xiangbing Bian, Chunlin Li and Dawei Li

Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.746564

Synergistic control of dual cross-linking strategy toward tailor-made hydrogels

Xueyu Dou, Qingchen Cao, Feifei Sun, Yaqiang Wang, Hufei Wang, Hong Shen, Fei Yang, Xing Wang and Decheng Wu

Sci. China Chem., 2020, 63, 1793
DOI: 10.1007/s11426-020-9821-2

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Guoke Tang, Zhihong Tan, Wusi Zeng, Xing Wang, Changgui Shi, Yi Liu, Hailong He, Rui Chen and Xiaojian Ye

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.587658

Hydrogel-based delivery system applied in the local anti-osteoporotic bone defects

Yining Gong, Yazhong Bu, Yongliang Li, Dingjun Hao, Baorong He, Lingbo Kong, Wangli Huang, Xiangcheng Gao, Bo Zhang, Zechao Qu, Dong Wang and Liang Yan

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1058300

In vitro/ex vivo evaluation of multifunctional collagen/chitosan/hyaluronic acid hydrogel-based alendronate delivery systems

Joanna Klara, Alicja Hinz, Monika Bzowska, Wojciech Horak and Joanna Lewandowska-Łańcucka

International Journal of Biological Macromolecules, 2024, 262, 130142
DOI: 10.1016/j.ijbiomac.2024.130142

Facile synthesis of mechanically robust and injectable tetra-polyethylene glycol/methacrylate chitosan double-network hydrogel cartilage repair

Rui Chen, Xiaojie Yu, Weiheng Wang, Liang Zhu, Ronghua Yu, Guoke Tang, Xing Wang and Jiangming Yu

Polymer Testing, 2024, 133, 108410
DOI: 10.1016/j.polymertesting.2024.108410

Matrix Metalloproteinase‐Responsive Hydrogel with On‐Demand Release of Phosphatidylserine Promotes Bone Regeneration Through Immunomodulation

Mingjin Zhang, Tingting Yu, Jing Li, Huichun Yan, Liang Lyu, Yi Yu, Gengchen Yang, Ting Zhang, Yanheng Zhou, Xing Wang and Dawei Liu

Advanced Science, 2024, 11
DOI: 10.1002/advs.202306924

Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review

Diego De Leon-Oliva, Diego Liviu Boaru, Roque Emilio Perez-Exposito, Oscar Fraile-Martinez, Cielo García-Montero, Raul Diaz, Julia Bujan, Natalio García-Honduvilla, Laura Lopez-Gonzalez, Melchor Álvarez-Mon, Jose V. Saz, Basilio de la Torre and Miguel A. Ortega

Gels, 2023, 9, 885
DOI: 10.3390/gels9110885

Light-Triggered Cross-Linking of Linear Poly(ethylene glycol) Hydrogels for Enhanced Antibacterial Delivery

Siyuan Liu, Yuan Tian, Kaijie Zhao, Peiyu Zhang, Jia Li and Jiwei Cui

Biomacromolecules, 2025, 26, 4848
DOI: 10.1021/acs.biomac.5c00266

Biomaterials for surgical repair of osteoporotic bone defects

Xu Luo, Jinwen Xiao, Qiming Yang, Xiaolong Lu, Qianjun Huang, Xiaojun Ai, Bo Li, Li Sun and Long Chen

Chinese Chemical Letters, 2025, 36, 109684
DOI: 10.1016/j.cclet.2024.109684

Translational Applications of Hydrogels

Santiago Correa, Abigail K. Grosskopf, Hector Lopez Hernandez, Doreen Chan, Anthony C. Yu, Lyndsay M. Stapleton and Eric A. Appel

Chem. Rev., 2021, 121, 11385
DOI: 10.1021/acs.chemrev.0c01177

Bioactive hydrogel formulations for regeneration of pathological bone defects

Zuhao Li, Kaixuan Ren, Jiajia Chen, Yaling Zhuang, Shujun Dong, Jincheng Wang, He Liu and Jianxun Ding

Journal of Controlled Release, 2025, 380, 686
DOI: 10.1016/j.jconrel.2025.01.061

Synergistic Therapy of Celecoxib-Loaded Magnetism-Responsive Hydrogel for Tendon Tissue Injuries

Jingxin Wang, Likang Wang, Yueming Gao, Zhao Zhang, Xiaofeng Huang, Tong Han, Biyuan Liu, Yujie Zhang, Yilan Li and Lining Zhang

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.592068