A strategy for orthogonal deubiquitination using a bump-and-hole approach

Takumi Suzuki, Yuki Utsugi, Satoshi Yamanaka, Hirotaka Takahashi, Yusuke Sato, Tatsuya Sawasaki and Yusaku Miyamae

RSC Chem. Biol., 2023, 4, 879
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Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Wioletta Rut, Mikolaj Zmudzinski, Scott J. Snipas, Miklos Bekes, Tony T. Huang and Marcin Drag

Chem. Sci., 2020, 11, 6058
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Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion

Sheng-Kai Hsu, Chon-Kit Chou, I-Ling Lin, Wen-Tsan Chang, I-Ying Kuo and Chien-Chih Chiu

Cell Commun Signal, 2024, 22
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Assay Systems for Profiling Deubiquitinating Activity

Jinhong Cho, Jinyoung Park, Eunice EunKyeong Kim and Eun Joo Song

IJMS, 2020, 21, 5638
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Imaging of proteases using activity-based probes

Mikolaj Zmudzinski, Oliwia Malon, Marcin Poręba and Marcin Drąg

Current Opinion in Chemical Biology, 2023, 74, 102299
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Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells

Yanyan Chen, Hao Jiang, Tingting Hao, Nan Zhang, Mingyu Li, Xingyun Wang, Xiuxiu Wang, Wei Wei and Jing Zhao

Chemical & Biomedical Imaging, 2023, 1, 590
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On the Study of Deubiquitinases: Using the Right Tools for the Job

Cody Caba, Azam Mohammadzadeh and Yufeng Tong

Biomolecules, 2022, 12, 703
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Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies

Jason Q. Tang, Mary M. Marchand and Gianluca Veggiani

Cells, 2023, 12, 2117
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Technologies for Direct Detection of Covalent Protein–Drug Adducts

Elma Mons, Robbert Q. Kim and Monique P. C. Mulder

Pharmaceuticals, 2023, 16, 547
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Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors

Shiyao Chen, Yunqi Liu and Huchen Zhou

IJMS, 2021, 22, 4546
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Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36

Rachel O’Dea, Nafizul Kazi, Alicia Hoffmann-Benito, Zhou Zhao, Sarah Recknagel, Kim Wendrich, Petra Janning and Malte Gersch

Nat Chem Biol, 2023, 19, 1394
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Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3

Chad S. Hewitt, Chittaranjan Das and Daniel P. Flaherty

Biomolecules, 2022, 12, 62
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USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

Jin Gan, Adán Pinto-Fernández, Dennis Flierman, Jimmy J. L. L. Akkermans, Darragh P. O’Brien, Helene Greenwood, Hannah Claire Scott, Günter Fritz, Klaus-Peter Knobeloch, Jacques Neefjes, Hans van Dam, Huib Ovaa, Hidde L. Ploegh, Benedikt M. Kessler, Paul P. Geurink and Aysegul Sapmaz

Proc. Natl. Acad. Sci. U.S.A., 2023, 120
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State of the art in (semi-)synthesis of Ubiquitin- and Ubiquitin-like tools

Yara Huppelschoten and Gerbrand J. van der Heden van Noort

Seminars in Cell & Developmental Biology, 2022, 132, 74
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Chemical biology tools to study Deubiquitinases and Ubl proteases

Magdalena Gorka, Helge Magnus Magnussen and Yogesh Kulathu

Seminars in Cell & Developmental Biology, 2022, 132, 86
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Covalent Small Molecule Immunomodulators Targeting the Protease Active Site

Hong-Rae Kim, Ravichandra Tagirasa and Euna Yoo

J. Med. Chem., 2021, 64, 5291
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Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

Raymond Kooij, Sijia Liu, Aysegul Sapmaz, Bo-Tao Xin, George M. C. Janssen, Peter A. van Veelen, Huib Ovaa, Peter ten Dijke and Paul P. Geurink

J. Am. Chem. Soc., 2020, 142, 16825
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