Bispidine coordination chemistry

Katharina Bleher, Patrick A. Cieslik and Peter Comba

Dalton Trans., 2025, 54, 4405
DOI: 10.1039/D5DT00050E

Theoretical study of heptadentate bispidine ligands for radiopharmaceutic applications

Attila Kovács

Computational and Theoretical Chemistry, 2022, 1212, 113716
DOI: 10.1016/j.comptc.2022.113716

Ring-System-Based Conformational Switches and their Applications in Sensing and Liposomal Drug Delivery

Hang Su and Christian Marcus Pedersen

Synthesis, 2022, 54, 4895
DOI: 10.1055/s-0040-1720045

64Cu tumor labeling with hexadentate picolinic acid‐based bispidine immunoconjugates

Manja Kubeil, Christin Neuber, Miriam Starke, Claudia Arndt, Liliana Rodrigues Loureiro, Lydia Hoffmann, Anja Feldmann, Michael Bachmann, Jens Pietzsch, Peter Comba and Holger Stephan

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400366

First‐Generation Bispidine Chelators for 213BiIII Radiopharmaceutical Applications

Frank Bruchertseifer, Peter Comba, Bodo Martin, Alfred Morgenstern, Johannes Notni, Miriam Starke and Hubert Wadepohl

ChemMedChem, 2020, 15, 1591
DOI: 10.1002/cmdc.202000361

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines

Ekaterina V. Neborak, Altynay B. Kaldybayeva, Lylia Bey, Aigul Y. Malmakova, Anna S. Tveritinova, Abdullah Hilal, Valentina K. Yu, Maria V. Ploskonos, Marina V. Komarova, Enzo Agostinelli and Dmitry D. Zhdanov

Molecules, 2022, 27, 3872
DOI: 10.3390/molecules27123872

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt

A. O. Kurskova, V. V. Dotsenko, K. A. Frolov, N. A. Aksenov, I. V. Aksenova, B. S. Krivokolysko, A. A. Peresypkina, E. A. Chigorina and S. G. Krivokolysko

Russ J Gen Chem, 2022, 92, 779
DOI: 10.1134/S1070363222050061

Eccentricities in Spectroscopy and Reactivity of Non‐Heme Metal Intermediates Contained in Bispidine Scaffolds

Gourab Mukherjee and Chivukula V. Sastri

Israel Journal of Chemistry, 2020, 60, 1032
DOI: 10.1002/ijch.202000045

Anticancer Activity of Bispidinone Derivative by Induction of Apoptosis

Man Gi Lee and Ryong Kwon

BSL, 2020, 26, 336
DOI: 10.15616/BSL.2020.26.4.336

Stable and inert manganese complexes for magnetic resonance imaging

Daouda Ndiaye and Éva Tóth

Comptes Rendus. Chimie, 2024, 27, 161
DOI: 10.5802/crchim.284

Bispidine Based Hg(II) 1D Coordination Polymers of Helical Topology: Stability, Selective Adsorption and 1D to 2D Dimensionality Change Via SC‐to‐SC Transformation

Alessandro Sayed and Massimo Cametti

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401464

Unprecedented Kinetic Inertness for a Mn2+‐Bispidine Chelate: A Novel Structural Entry for Mn2+‐Based Imaging Agents

Daouda Ndiaye, Maryame Sy, Agnès Pallier, Sandra Même, Isidro de Silva, Sara Lacerda, Aline M. Nonat, Loïc J. Charbonnière and Éva Tóth

Angew Chem Int Ed, 2020, 59, 11958
DOI: 10.1002/anie.202003685

Exceptional Manganese(II) Stability and Manganese(II)/Zinc(II) Selectivity with Rigid Polydentate Ligands**

Patrick Cieslik, Peter Comba, Benedikt Dittmar, Daouda Ndiaye, Éva Tóth, Gunasekaran Velmurugan and Hubert Wadepohl

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202115580

Structural Variations in Carboxylated Bispidine Ligands: Influence of Positional Isomerism and Rigidity on the Conformation, Stability, Inertness and Relaxivity of their Mn2+ Complexes

Daouda Ndiaye, Maryame Sy, Waygen Thor, Loïc J. Charbonnière, Aline M. Nonat and Éva Tóth

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301880

Bispidine-based Ligands as Bifunctional Chelators for Radiopharmaceuticals

Rui Li, Yuting Yan, Xiyan Ren, Hongyu Li and Jianhui Huang

COC, 2025, 29, 679
DOI: 10.2174/0113852728346887240924050723

Exceptional Manganese(II) Stability and Manganese(II)/Zinc(II) Selectivity with Rigid Polydentate Ligands**

Patrick Cieslik, Peter Comba, Benedikt Dittmar, Daouda Ndiaye, Éva Tóth, Gunasekaran Velmurugan and Hubert Wadepohl

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202115580

Unprecedented Kinetic Inertness for a Mn2+‐Bispidine Chelate: A Novel Structural Entry for Mn2+‐Based Imaging Agents

Daouda Ndiaye, Maryame Sy, Agnès Pallier, Sandra Même, Isidro de Silva, Sara Lacerda, Aline M. Nonat, Loïc J. Charbonnière and Éva Tóth

Angewandte Chemie, 2020, 132, 12056
DOI: 10.1002/ange.202003685

1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction

V. V. Dotsenko, A. N. Khrustaleva, K. A. Frolov, N. A. Aksenov, I. V. Aksenova and S. G. Krivokolysko

Russ J Gen Chem, 2021, 91, 44
DOI: 10.1134/S1070363221010047

Excited State Properties of Lanthanide(III) Complexes with a Nonadentate Bispidine Ligand

Laura Abad‐Galán, Patrick Cieslik, Peter Comba, Michael Gast, Olivier Maury, Lucca Neupert, Amandine Roux and Hubert Wadepohl

Chemistry A European J, 2021, 27, 10303
DOI: 10.1002/chem.202005459

Evaluation of a Bispidine‐Based Chelator for Gallium‐68 and of the Porphyrin Conjugate as PET/PDT Theranostic Agent

Thomas W. Price, Steven Y. Yap, Raphaël Gillet, Huguette Savoie, Loïc J. Charbonnière, Ross W. Boyle, Aline M. Nonat and Graeme J. Stasiuk

Chemistry A European J, 2020, 26, 7602
DOI: 10.1002/chem.201905776

Octadentate Bispidine Chelators for Tb(III) Complexation: Pyridine Carboxylate versus Pyridine Phosphonate Donors

Lucas Petitpoisson, Anli Mahamoud, Valérie Mazan, Maryame Sy, Olivier Jeannin, Eva Tóth, Loïc J. Charbonnière, Mourad Elhabiri and Aline M. Nonat

Inorg. Chem., 2024, 63, 22829
DOI: 10.1021/acs.inorgchem.4c03691

Metal–Ligand Interactions in Scandium Complexes with Radiopharmaceutical Applications

Attila Kovács

Inorg. Chem., 2023, 62, 20733
DOI: 10.1021/acs.inorgchem.3c02211

Metal-ligand bonding in bispidine chelate complexes for radiopharmaceutical applications

Attila Kovács

Struct Chem, 2023, 34, 5
DOI: 10.1007/s11224-022-01902-6

Mn2+ Bispidine Complexes as Potential Magnetic Resonance Imaging Agents : Noncoordinating Peripheral Functional Groups Affect Structural, Kinetic, and Relaxation Properties

Maryame Sy, Daouda Ndiaye, Hervé Meudal, Loïc J. Charbonnière, Aline M. Nonat and Éva Tóth

ChemistryEurope, 2026, 4
DOI: 10.1002/ceur.202500263

Metal Complexes of Bispidine Derivatives: Achievements and Prospects for the Future

Altynay B. Kaldybayeva, Valentina K. Yu, Feyyaz Durap, Murat Aydemir and Khaidar S. Tassibekov

Molecules, 2025, 30, 1138
DOI: 10.3390/molecules30051138

Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics

Ian Moore F. Gilpin, Martin Ullrich, Thomas Wünsche, Kristof Zarschler, Ondřej Lebeda, Jens Pietzsch, Hans‐Jürgen Pietzsch and Martin Walther

ChemMedChem, 2021, 16, 2645
DOI: 10.1002/cmdc.202100131

55/52Mn2+ Complexes with a Bispidine-Phosphonate Ligand: High Kinetic Inertness for Imaging Applications

Maryame Sy, Daouda Ndiaye, Isidro da Silva, Sara Lacerda, Loïc J. Charbonnière, Éva Tóth and Aline M. Nonat

Inorg. Chem., 2022, 61, 13421
DOI: 10.1021/acs.inorgchem.2c01681

Exploring VOCs Adsorption in a New Series of Hg(II) Bispidine-Based Coordination Polymers

Martina Lippi, Meriem Goudjil, Emilio Valentini, Patrizia Rossi, Paola Paoli and Massimo Cametti

Inorganica Chimica Acta, 2025, 577, 122469
DOI: 10.1016/j.ica.2024.122469

Versatile Bispidine‐Based Bifunctional Chelators for 64CuII‐Labelling of Biomolecules

Garima Singh, Kristof Zarschler, Sebastian Hunoldt, Irma Ivette Santana Martínez, Carmen L. Ruehl, Madlen Matterna, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Michael Bachmann, Peter Comba and Holger Stephan

Chemistry A European J, 2020, 26, 1989
DOI: 10.1002/chem.201904654

Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide, and Main Group Metal Ions

Ina Kopp, Patrick Cieslik, Karl Anger, Thomas Josephy, Lucca Neupert, Gunasekaran Velmurugan, Michael Gast, Hubert Wadepohl, Santiago Andrés Brühlmann, Martin Walther, Klaus Kopka, Michael Bachmann, Holger Stephan, Manja Kubeil and Peter Comba

Inorg. Chem., 2023, 62, 20754
DOI: 10.1021/acs.inorgchem.3c02340

Emerging chelators for nuclear imaging

Deborah Sneddon and Bart Cornelissen

Current Opinion in Chemical Biology, 2021, 63, 152
DOI: 10.1016/j.cbpa.2021.03.001

Synthesis and Characterization of New Triazole-Bispidinone Scaffolds and Their Metal Complexes for Catalytic Applications

Arianna Rossetti, Alessandro Sacchetti, Fiorella Meneghetti, Greta Colombo Dugoni, Matteo Mori and Carlo Castellano

Molecules, 2023, 28, 6351
DOI: 10.3390/molecules28176351

Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds

Jacob C. Hood, Yannick Tshikaya, Aaren R. Manz, Marcus C. LaPorte and Douglas A. Klumpp

J. Org. Chem., 2022, 87, 4908
DOI: 10.1021/acs.joc.1c02655