Geminal homologative fluorination of carbonyl derivatives en route to 1-fluoro-2-haloethyl skeletons

Abstract

Carbonyl groups undergo the sequential installation of two nucleophilic elements, halomethyl and fluoride moieties. This formal gem-difunctionalization enables the preparation–under full chemocontrol – of vic-fluorohaloethanes by simply defining the C1 nucleophile, thus enabling access to all combinations of the four halogens.