A novel 16-hydroxy-palmitic acid tethered D-configured homo-chiral triphenylalanine based nanofibrillar scaffold with innate anticancer potential

Vaibhav Shivhare; Arindam Gupta; Rishabh Ahuja; Dipesh Barde; Surendra Kumar Ahirwar; Anindya Basu; Anita Dutt Konar

doi:10.1039/D5CC01500F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A novel 16-hydroxy-palmitic acid tethered d-configured homo-chiral triphenylalanine based nanofibrillar scaffold with innate anticancer potential†

Vaibhav Shivhare,

^a Arindam Gupta,

^b Rishabh Ahuja,

^a Dipesh Barde,

^a Surendra Kumar Ahirwar,

^a Anindya Basu

^cd and Anita Dutt Konar

*^acd

Author affiliations

* Corresponding authors

^a Department of Chemistry, Rajiv Gandhi Technological University, Bhopal, India
E-mail: anitaduttkonar@rgpv.ac.in

^b Department of Chemistry, IISER Bhopal, India

^c School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal, India

^d University Grants Commission, India

Abstract

A homochiral triphenylalanine system when tethered to 16-hydroxy-palmitic acid at the N-terminus displays excellent gelation propensity with mechanoresponsiveness and innate anticancer potential. We anticipate that the amphiphile–lactate derivative compound VI plays a pivotal role in addressing the cancer related challenges probably via an extrinsic apoptotic pathway.

Download options Please wait...

Supplementary files

Supplementary information PDF (7477K)

Article information

DOI: https://doi.org/10.1039/D5CC01500F
Article type: Communication
Submitted: 17 মার্চ 2025
Accepted: 09 মে 2025
First published: 14 মে 2025

Download Citation

Chem. Commun., 2025,61, 9717-9720

Permissions

Request permissions

A novel 16-hydroxy-palmitic acid tethered D-configured homo-chiral triphenylalanine based nanofibrillar scaffold with innate anticancer potential

V. Shivhare, A. Gupta, R. Ahuja, D. Barde, S. K. Ahirwar, A. Basu and A. D. Konar, Chem. Commun., 2025, 61, 9717 DOI: 10.1039/D5CC01500F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

A novel 16-hydroxy-palmitic acid tethered d-configured homo-chiral triphenylalanine based nanofibrillar scaffold with innate anticancer potential†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A novel 16-hydroxy-palmitic acid tethered D-configured homo-chiral triphenylalanine based nanofibrillar scaffold with innate anticancer potential

Social activity

Search articles by author

Spotlight

Advertisements