Issue 39, 2016

Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Abstract

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.

Graphical abstract: Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Supplementary files

Article information

Article type
Communication
Submitted
08 এপ্রিল 2016
Accepted
18 এপ্রিল 2016
First published
18 এপ্রিল 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 6537-6540

Author version available

Stabilisation of an amorphous form of ROY through a predicted co-former interaction

P. A. Corner, J. J. Harburn, J. W. Steed, J. F. McCabe and D. J. Berry, Chem. Commun., 2016, 52, 6537 DOI: 10.1039/C6CC02949C

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