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Abstract | Cited by

The effect of flexible linker length in dimeric prodrugs was explained through their aggregation structures, as revealed by molecular dynamics simulations. The results indicated that the aggregation structure of the dimeric prodrug was controlled by the molecular structure (mainly flexible linkers) as an internal factor and the fabrication methods as an external factor.

Graphical abstract: Structural aspects of dimeric prodrug-based carrier-free nanomedicines for tumor chemotherapy

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