Issue 6, 2022

Sustainable C–H functionalization under ball-milling, microwave-irradiation and aqueous media

Abstract

Transition metal mediated C–H functionalization has been highly relevant in organic synthesis for decades. However, sustainability as an inherent feature in such transformations remains under-developed. Through a varied approach, we have explored metal-centered catalysis practiced via mechanochemistry and under microwave-irradiation, both strictly without the use of any toxic organic solvents. In some sections of this report, we shed light upon C–H functionalizations carried out in the universal and clean solvent water, as well as in neat, solvent-devoid conditions. Different metal centers like Pd, Rh, Ru, Cu, Fe, Co and a spectrum of mechanistic pathways that have accomplished these reactions in an unconventional but green protocol, are discussed extensively. This serves as an attempt to address the challenges in environmental preservation while carrying out organic reactions, and to encourage innovative versatile ideas. Our review collectively presents the endeavours that have introduced hazard-free methodologies in these C–H activation pathways.

Graphical abstract: Sustainable C–H functionalization under ball-milling, microwave-irradiation and aqueous media

Article information

Article type
Tutorial Review
Submitted
05 ডিচে 2021
Accepted
24 জানু 2022
First published
24 জানু 2022

Green Chem., 2022,24, 2296-2320

Sustainable C–H functionalization under ball-milling, microwave-irradiation and aqueous media

R. Laskar, T. Pal, T. Bhattacharya, S. Maiti, M. Akita and D. Maiti, Green Chem., 2022, 24, 2296 DOI: 10.1039/D1GC04530J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements