Zhou Sun, Xue-Song Zhang, Shao-Wei Bian, Chun Zhang, Ya-Ping Han and Yong-Min Liang
Org. Biomol. Chem., 2025,23, 3029-3075
Abstract
In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
Zinatossadat Hossaini, Zahra Azizi, Aytan Niazova, Somayeh Soleimani-Amiri, Ali Z. Zalov, Huseyn A. Imanov, Afet T. Huseynova, Mohauman Mohammed Majeed Alrufaie and Esmail Vessally
RSC Adv., 2026,16, 21115-21128
Abstract
We highlight the most significant advances and developments in the direct C–H difluoromethylation of heteroaromatic compounds reported up to the end of 2025.
Yu-En Huang, Kakeru Konagaya and Shigekazu Ito
Org. Biomol. Chem., 2025,23, 6225-6230
Abstract
The intermediary-produced CF2H radical, produced by one-electron oxidation of difluoromethylborates [pinB(Aryl)CF2H][K(18-cr-6)] using photo-redox catalysts, is advantageous for synthesizing the difluoromethylated benzene-fused γ-sultams.
Kehan Zhou, Shuang Xia, Yuheng Xiao, Zhibin Huang, Jingyu Zhang and Yingsheng Zhao
Org. Chem. Front., 2024,11, 4874-4881
Abstract
The incorporation of a difluoromethyl group within an aromatic ring is highly desirable.
Jiaran Yang, Hongxiang Li, Meiming Luo and Xiaoming Zeng
Chem. Commun., 2026,62, 7791-7795
Abstract
We report a chromium-catalyzed allylic difluoromethylation of α-trifluoromethyl alkenes, allowing one-step access to polyfluorinated compounds characterised by both gem-difluoroalkene and difluoromethyl groups.