A copper-catalyzed reaction of sulfoxonium ylides with cyclic ethynylethylene carbonates is described, enabling access to functionalized vinyl sulfoxonium ylides via nucleophilic addition and rearrangement.
A copper-catalyzed decarboxylative cyclization of cyclic ethynylethylene carbonates with anthranils is reported for the first time, delivering diverse spirodihydrofurans with a versatile carbon–halogen bond and an aldehyde functional group.
Conformational rigidity dependent chemodivergent annulation between α-aminoketones and cyclic ethynylethylene carbonates has been developed. Reducing the amine nucleophilicity via H-bonding enabled allenal reactivity, instead of Cu-allenylidene.
This review has summarized the development of organocatalytic asymmetric [3 + 3] cycloadditions and given insights into the remaining challenges to promote the future development of this field.
A weak base mediated spontaneous transformation of the active esters of N-protected (E)-α,β-unsaturated γ-amino acids into N-protected (Z)-α,β-unsaturated γ-lactams is described.