In this study, we report a skeletal editing strategy for the modular synthesis of bipyrazole energetic compounds. This study reveals that skeletal editing via distinctive retrosynthetic logic offers new opportunities in synthesizing HEDMs.
An advanced tetracyclic heat-resistant explosive compound 3 with high thermal stability and good detonation performance was prepared by introducing a high-energy bis(4-nitropyrazole) bridge between two 4H-1,2,4-triazole-3,4-diamine frameworks.
An energetic compound with a trinitromethyl group has been achieved via a novel strategy of nitration of an ethylene bridged compound and shows excellent heat of detonation and promising properties.
Increasing the strength and number of hydrogen bonds of azoles and expanding the π–π stacking area are the key factors to improve the thermal stability, which provides a valuable way for developing energetic materials with higher energy and thermal stability.
The synthetic methods and physicochemical properties of geminal dinitro and trinitromethyl substituted aliphatic compounds, monocyclic azoles, bisazoles, fused heterocycles, and cage adamantanes are reviewed.