A novel strategy for the selective synthesis of (E)-vinyl sulfone derivatives from p-tosylmethyl isocyanide (TosMIC) and ortho-substituted benzaldehydes has been established.
Two copper-controlled reactions of 2H-azirines with TosMICs have been developed that provide two efficient and modular approaches to diverse substituted pyrimidines with non-electron-withdrawing substituents at position 4 or 6.
Herein a rapid continuous flow method for the conversion of aryl ketones to nitriles is presented, which features advantages such as improved safety, substrate scope and scalability.
A base-promoted approach has been devised for the synthesis of pyrrole derivatives via a [3 + 2] cycloaddition reaction of propiolonitriles with isocyanides within 10–90 min.
Herein, we report highly efficient and base-promoted approaches for the diversity-oriented synthesis of 2,5- and 4,5-disubstituted thiazoles using alkyl 2-(methylthio)-2-thioxoacetates as synthetic precursors.