DFT calculations clarify the mechanism of Pd/phosphine ligand/norbornene-catalyzed aryl chloride difunctionalization, rationalizing chemoselectivity and the roles of norbornene and XPhos ligand.
Herein, we report a novel approach to pyrroloiminoquinones which was enabled by the development of a Larock/Buchwald–Hartwig annulation/cyclization cascade to rapidly construct the core, which was further elaborated to 5 of these natural products.
In this study, we present a waste-minimized strategy for synthesising diarylamines and triarylamines via Buchwald–Hartwig coupling.
The synthesis and catalytic activity of novel phosphine palladium PEPPSI and dimer complexes bearing RuPhos, SPhos and XPhos phosphines is reported.
This work describes a ligand-controlled regioselective ring-opening/defluorinative annulation of gem-DFCPs with enaminones, which provides an alternative strategy for the divergent synthesis of pyrroles.