Phytochemical composition and bioactivity of edible Taraxacum officinale: potential as an ingredient in brain health-oriented functional foods

Fabrizio Masciulli, Donatella Ambroselli, Maria Loreta Libero, Alessandra Acquaviva, Simonetta Cristina Di Simone, Annalisa Chiavaroli, Luigi Menghini, Claudio Ferrante, Giustino Orlando, Luisa Mannina and Cinzia Ingallina

Food Funct., 2025, 16, 7217
DOI: 10.1039/D5FO02646F

Lycium ruthenicum Murray anthocyanin-driven neuroprotection modulates the gut microbiome and metabolome of MPTP-treated mice

Hongdou Cao, Qi Tian, Liwen Chu, Lingyu Wu, Hua Gao and Qinghan Gao

Food Funct., 2024, 15, 12210
DOI: 10.1039/D4FO01878H

The role of the gut microbiota in neuropsychiatric disorders and therapy

Fan Zhang, Kang Ding, Lin-Mei Zhang, Dong-Yao Liu, Xin Dong, Man-Ni Wang, Fu-Lin Zhou, Yi-Wei Sun, Wei-Ku Zhang, Yu Yan, Jun He and Jie-Kun Xu

Ageing Research Reviews, 2025, 112, 102894
DOI: 10.1016/j.arr.2025.102894

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Ruonan Wang, Shijia Kang, Zirui Zhao, Lingling Jin, Xiaolin Cui, Lili Chen, Melitta Schachner, Sheng Li, Yanjie Guo and Jie Zhao

IJMS, 2024, 25, 3408
DOI: 10.3390/ijms25063408

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Bruno Bonnechère, Najaf Amin and Cornelia van Duijn

IJMS, 2022, 23, 13665
DOI: 10.3390/ijms232213665

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Divya Soni, Sumit Jamwal, Rakesh Chawla, Sachin Kumar Singh, Deependra Singh, Thakur Gurjeet Singh, Navneet Khurana, Abhinav Kanwal, Harish Dureja, Umesh Kumar Patil, Randhir Singh and Puneet Kumar

Food Reviews International, 2024, 40, 3079
DOI: 10.1080/87559129.2024.2337766

Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies

Wanlin Zhao, Hailiang Cui, Jihong Liu, Hongyu Sun, Zijuan Zhang, Zhenqiang Zhang and Dongrui Ma

Cell Mol Neurobiol, 2025, 45
DOI: 10.1007/s10571-025-01556-y

Effects of polyphenol on motor function in mice with Parkinson’s disease: a systematic review and meta-analysis

Hongdou Cao, Qi Tian, Liwen Chu and Qinghan Gao

Critical Reviews in Food Science and Nutrition, 2025, 65, 2859
DOI: 10.1080/10408398.2024.2352541

Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders

Rohan Gupta, Dia Advani, Divya Yadav, Rashmi K Ambasta and Pravir Kumar

Mol Neurobiol, 2023, 60, 6476
DOI: 10.1007/s12035-023-03502-9

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Ying Jia, Yuanyuan Zhang, Xin Tai, Tengyu Zhao, Hanwen Zhang and Haichun Zhou

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1667694

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Mohamed I. Fahmy, Ranwa A. Elrayess, Musaad M. Althobaiti, Hany H. Arab and Amira Rashad

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.202400935

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Hao Cheng, Dandan Zhang, Jing Wu, Juan Liu, Yaochuan Zhou, Yuzhu Tan, Wuwen Feng and Cheng Peng

Phytomedicine, 2023, 119, 154979
DOI: 10.1016/j.phymed.2023.154979

Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases

Tong Nie, Li You, Fang Tang, Yanhui Duan, Eugenie Nepovimova, Kamil Kuca, Qinghua Wu and Wei Wei

CN, 2025, 23, 524
DOI: 10.2174/1570159X23666241101093436

Systematic review and meta-analysis of microbiota-gut-astrocyte axis perturbation in neurodegeneration, brain injury, and mood disorders

Daniel E. Radford-Smith, Katharine Oke, Carolina F.F.A. Costa and Daniel C. Anthony

Brain, Behavior, & Immunity - Health, 2025, 46, 101013
DOI: 10.1016/j.bbih.2025.101013

Chicoric Acid Effectively Mitigated Dextran Sulfate Sodium (DSS)-Induced Colitis in BALB/c Mice by Modulating the Gut Microbiota and Fecal Metabolites

Jiani Yang, Jie Lin, Ting Gu, Quancai Sun, Weidong Xu and Ye Peng

IJMS, 2024, 25, 841
DOI: 10.3390/ijms25020841

Cordycepin ameliorates acute hypobaric hypoxia induced blood-brain barrier disruption, and cognitive impairment partly by suppressing the TLR4/NF-κB/MMP-9 pathway in the adult rats

Pengfei Liu, Lei Pan, Lei Cui, Tianzuo Li, Sheng Zhao, Yanting Hu, Xiaomei Tao, Hui Deng, Jingwen Jiang, Binjiang Zhao, Yong Wang and Xinying Xue

European Journal of Pharmacology, 2022, 924, 174952
DOI: 10.1016/j.ejphar.2022.174952

Aqueous Extract of Brassica rapa L.’s Impact on Modulating Exercise-Induced Fatigue via Gut–Muscle Axis

Cheng Wang, Hongkang Zhu, Yuliang Cheng, Yahui Guo, Yong Zhao and He Qian

Nutrients, 2023, 15, 4737
DOI: 10.3390/nu15224737

17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice

Xiang Zuo, Hui-Juan Bai, Qi-Li Zhao, Shu-Hui Zhang, Xin Zhao and Xi-Zeng Feng

Mol Neurobiol, 2025, 62, 3053
DOI: 10.1007/s12035-024-04455-3

Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy‐induced bone loss

Yansi Xian, Yijie Gao, Yiji Su, Yuangang Su, Haoyu Lian, Xiaoliang Feng, Zhijuan Liu, Jinmin Zhao, Jiake Xu, Qian Liu and Fangming Song

Phytotherapy Research, 2024, 38, 1971
DOI: 10.1002/ptr.8141

Natural products: Harnessing the power of gut microbiota for neurological health

Hao Cheng, Juan Liu, Dandan Zhang, Jing Wu, Jinlu Wu, Yaochuan Zhou, Yuzhu Tan, Wuwen Feng and Cheng Peng

Phytomedicine, 2024, 135, 156019
DOI: 10.1016/j.phymed.2024.156019

The interplay between gut microbiota and the brain-gut axis in Parkinson’s disease treatment

Xi Jia, Qin Wang, Meilingzi Liu and Jia-yuan Ding

Front. Neurol., 2024, 15
DOI: 10.3389/fneur.2024.1415463

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Amrita Chatterjee, Satish Kumar, Suparna Roy Sarkar, Ritabrata Halder, Rashmi Kumari, Sugato Banerjee and Biswatrish Sarkar

The Journal of Nutritional Biochemistry, 2024, 129, 109622
DOI: 10.1016/j.jnutbio.2024.109622

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Nerea Domínguez Rojo, Mercedes Blanco Benítez, Ramón Cava, José Manuel Fuentes, Saray Canales Cortés and Rosa Ana González Polo

IJMS, 2024, 25, 11629
DOI: 10.3390/ijms252111629

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Lan Yang, Jianfei Nao and Xiaoyu Dong

J. Agric. Food Chem., 2023, 71, 10932
DOI: 10.1021/acs.jafc.3c02787

Neuroprotective Effects of Lactobacillus plantarum PS128 in a Mouse Model of Parkinson’s Disease: The Role of Gut Microbiota and MicroRNAs

Yan Zhang Lee, Shih-Hsuan Cheng, Min-Yu Chang, Yu-Fen Lin, Chien-Chen Wu and Ying-Chieh Tsai

IJMS, 2023, 24, 6794
DOI: 10.3390/ijms24076794

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

Jian Yang, Yi Lei, Junlin Yan, Yewei Zhong, Adalaiti Abudurexiti, Huiwen Tan, Yinsong Ye, Rui Zhang, Fenglian Tong and Xiaoli Ma

Natural Product Communications, 2024, 19
DOI: 10.1177/1934578X241248237

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Xiliang Yang, Die Hu, Ruoyan Cheng, Qianqian Bao, Huan Jiang, Binjie Zhao and Yani Zhang

Phytochem Rev, 2025
DOI: 10.1007/s11101-025-10081-1

Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia

Na Li, Yanli Li, Junchao Huang, Ping Zhang, Jinghui Tong, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Elliot Hong, Chiang-Shan R. Li, Li Tian and Yunlong Tan

Neuroscience Letters, 2022, 777, 136581
DOI: 10.1016/j.neulet.2022.136581

Chicoric acid ameliorates LPS-induced inflammatory injury in bovine lamellar keratinocytes by modulating the TLR4/MAPK/NF-κB signaling pathway

Xiang Lan, Dongdong Qi, Hao Ren, Tao Liu, Hong Shao and Jiantao Zhang

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-49169-z

Detection of Volatile Organic Compounds as an emerging strategy for Parkinson’s disease diagnosis and monitoring

Ilaria Belluomo, Munir Tarazi, Nicholas P. Lao-Kaim, Yen F. Tai, Patrik Spanel and George B. Hanna

npj Parkinsons Dis., 2025, 11
DOI: 10.1038/s41531-025-00993-2

Chicoric Acid Prevents Neuroinflammation and Neurodegeneration in a Mouse Parkinson’s Disease Model: Immune Response and Transcriptome Profile of the Spleen and Colon

Ning Wang, Rui Li, Bainian Feng, Yuliang Cheng, Yahui Guo and He Qian

IJMS, 2022, 23, 2031
DOI: 10.3390/ijms23042031

Gut microbiota dysbiosis induces neuroinflammation in major depressive disorders: mechanisms targeting the gut-brain axis

Jiayi Li, Bei Wan, Le Zhou, Xin Qian, Fushun Wang, Simeng Gu, Xianjun Ma and Jason H. Huang

Front. Psychiatry, 2025, 16
DOI: 10.3389/fpsyt.2025.1629182

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Ahsas Goyal, Nandini Dubey, Anant Agrawal, Rashmi Sharma and Aanchal Verma

CPB, 2024, 25, 1708
DOI: 10.2174/0113892010280616231127075921

Phenolic acids from Chicory roots ameliorate dextran sulfate sodium–induced colitis in mice by targeting TRP signaling pathways and the gut microbiota

Yuwen Tian, Tunyu Jian, Jin Li, Lushi Huang, Shen Li, Hao Lu, Guanting Niu, Xiuhua Meng, Bingru Ren, Huarong Liao, Xiaoqin Ding and Jian Chen

Phytomedicine, 2024, 128, 155378
DOI: 10.1016/j.phymed.2024.155378

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Léonie Láng, Simon McArthur, Alpar S. Lazar, Line Pourtau, David Gaudout, Matthew G. Pontifex, Michael Müller and David Vauzour

Nutrients, 2024, 16, 1500
DOI: 10.3390/nu16101500

Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson’s Disease: Implications for Gut Microbiota and PGC-1α

Yuxuan Dong, Yueyan Qi, Jinhu Chen, Siyuan Han, Wenjing Su, Xin Ma, Yang Yu and Yanqin Wang

Mol Neurobiol, 2024, 61, 7534
DOI: 10.1007/s12035-024-04038-2

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Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Richmond Arthur and Puneet Kumar

Inflammopharmacol, 2024, 32, 2921
DOI: 10.1007/s10787-024-01510-2

Phytochemicals from edible flowers prevent neurodegenerative diseases via the gut-brain axis

Fatemeh Abbaszadeh, Sajad Fakhri, Behrang Shiri Varnamkhasti, Seyed Zachariah Moradi, Mohammad Reza Khirehgesh and Javier Echeverría

Food Bioscience, 2025, 63, 105681
DOI: 10.1016/j.fbio.2024.105681

Gut Microbiota Defined Epigenomes of Alzheimer’s and Parkinson’s Diseases Reveal Novel Targets for Therapy

Shabnam Nohesara, Hamid Mostafavi Abdolmaleky, Sam Thiagalingam and Jin-Rong Zhou

Epigenomics, 2024, 16, 57
DOI: 10.2217/epi-2023-0342

Parkinson’s Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration

Georgia Xiromerisiou, Chrysoula Marogianni, Anastasia Androutsopoulou, Panagiotis Ntavaroukas, Dimitrios Mysiris and Stamatia Papoutsopoulou

Biology, 2023, 12, 93
DOI: 10.3390/biology12010093