An 8-arylselenium BODIPY fluorescent probe for rapid and sensitive discrimination of biothiols in living cells

Yuan Mei, Hao Li, Cheng-Zhou Song, Xiang-Gen Chen and Qin-Hua Song

Chem. Commun., 2021, 57, 10198
DOI: 10.1039/D1CC03912A

Real-time, sensitive and simultaneous detection of GSH and Cys/Hcy by 8-substituted phenylselenium BODIPYs: a structure–activity relationship

Yuan Mei and Qin-Hua Song

J. Mater. Chem. B, 2022, 10, 6009
DOI: 10.1039/D2TB01189A

Rational design of a dual-reactive probe for imaging the biogenesis of both H2S and GSH froml-Cys rather thand-Cys in live cells

Haishun Ye, Longhuai Cheng, Xiaoqiang Tu, Da-Wei Wang and Long Yi

RSC Chem. Biol., 2022, 3, 848
DOI: 10.1039/D2CB00105E

Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems

Yongqing Zhou, Xuan Kuang, Xiaofeng Yang, Juan Li, Xianzhe Wei, Won Jun Jang, Shan-Shan Zhang, Mei Yan and Juyoung Yoon

Chem. Sci., 2024, 15, 19669
DOI: 10.1039/D4SC06722C

Activatable organic photoacoustic probes for in vivo anion imaging

Yurong Liu, Xinming Zhang, Shan Lei, Jing Lin and Peng Huang

Mater. Chem. Front., 2023, 7, 775
DOI: 10.1039/D2QM01207C

A novel electrochemical conducting polymer sensor for the rapid, selective and sensitive detection of biothiols

Bicheng Zhu, Devon T. Bryant, Alireza Akbarinejad, Jadranka Travas-Sejdic and Lisa I. Pilkington

Polym. Chem., 2022, 13, 508
DOI: 10.1039/D1PY01394G

Endogenous cysteine fluorescence monitoring and its deployment in tumour demarcation

Yongkang Yue, Tingting Zhao, Kaiqing Ma, Fangjun Huo and Caixia Yin

Chem. Commun., 2022, 58, 2311
DOI: 10.1039/D1CC06765F

Recent advances in glutathione fluorescent probes based on small organic molecules and their bioimaging

Jingdong Wang, Caixia Yin and Fangjun Huo

Analyst, 2025, 150, 220
DOI: 10.1039/D4AN01373E

B-Ring-extended flavonol-based photoCORM: activated by cysteine-ratiometric fluorescence sensing and accurate control of linear CO release

Ying-Ji Sun and Chao Yu

J. Mater. Chem. B, 2021, 9, 8263
DOI: 10.1039/D1TB01093J

Dye-sensitized lanthanide-doped upconversion nanoprobes for homocysteine sensing in human serum and living cells via a spatial optimization strategy

Zi-Hang Zhang, Zuo-Qin Liang, Su-Hang Xu, Pu Wang, Guo-Liang Dai, Chang-Qing Ye and Dong-Mei Wang

J. Mater. Chem. B, 2025, 13, 6093
DOI: 10.1039/D5TB00076A

Cysteine ratiometric fluorescence sensing reaction actuated B-ring naphthalene-substituted flavonol-based PhotoCORM: precisely controlled linear CO liberation

Ying-Ji Sun, Bei Liu, Deng-Jie Zhao, Yi Zhang and Chao Yu

New J. Chem., 2022, 46, 16151
DOI: 10.1039/D2NJ02897B

Host–guest type multiple site fluorescent probe for GSH detection in living organisms

Tao Liu, Yongkang Yue, Yunze Zhai, Zilong Guo, Wenjing Zhao, Xufeng Yang, Dongdong Chen and Caixia Yin

Chem. Commun., 2021, 57, 13764
DOI: 10.1039/D1CC05494E

A steric hindrance-regulated probe with single excitation dual emissions for self-adaptive detection of biothiols and H2S in human urine samples and living cells

Zhan Wang, Wenbo Shi, Yi-Jun Gong, Yanjun Du, Wei Luo, Huang Zhou and Ke Pan

J. Mater. Chem. B, 2025, 13, 2767
DOI: 10.1039/D4TB02787F

Sensing biothiols via thiol-chromene addition triggered fluorophore activation by intramolecular cyclization

Lijia Liu, Xiang Zhang, Minmin Zuo, Haiyang Cui, Xiaoqian Liu, Yajing Wang, Hua-Dong Xu, Zhenjiang Ding and Guodong Hu

Analyst, 2025, 150, 4665
DOI: 10.1039/D5AN00674K

Selenenylsulfide covalent-directed chemistry for the detection of sulfhydryl groups using a diselenide fluorescent probe

Chunqiu Ma, Jichao Xu, Xiaolu Wang, Xuewen Wang, Lei Zhang and Su Jing

RSC Adv., 2024, 14, 36754
DOI: 10.1039/D4RA05923A

An α-naphtholphthalein-derived colorimetric fluorescent chemoprobe for the portable and visualized monitoring of Hg2+by the hydrolysis mechanism

Daoyong Jiang, Xiuwen Zhang, Yizhao Chen, Pengfei Zhang, Ping Gong, Lintao Cai and Yong Wang

New J. Chem., 2022, 46, 11695
DOI: 10.1039/D2NJ01051H

LD and ER targeted cysteine fluorescence sensing driven A/B-ring-naphthalene/indole simultaneously substituted water hypersensitive flavonol: simultaneous dual-colour visualization of LDs and ER, and precisely controlled linear CO delivery

Ying-Ji Sun, Deng-Jie Zhao and Yi Zhang

J. Mater. Chem. B, 2025, 13, 6429
DOI: 10.1039/D5TB00141B

Diselenides as novel effective fluorescence quenchers to construct a two-photon fluorescent probe for thiols in a mouse stroke model

Tao Ma, Hao Gao, Jun Wu, Jintao Zhao, Bingbing Chang, Zhibin Zhang, Shengxiang Zhang, Baoxin Zhang and Jianguo Fang

Chem. Commun., 2025, 61, 1910
DOI: 10.1039/D4CC06286H

Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes

Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang and Bolin Chen

J. Mater. Chem. B, 2025, 13, 239
DOI: 10.1039/D4TB01656D

HSA-Lys-161 covalent bound fluorescent dye for in vivo blood drug dynamic imaging and tumor mapping

Yongkang Yue, Tingting Zhao, Yuting Wang, Kaiqing Ma, Xingkang Wu, Fangjun Huo, Fangqin Cheng and Caixia Yin

Chem. Sci., 2022, 13, 218
DOI: 10.1039/D1SC05484H

Investigation of thiolysis of 4-substituted SBD derivatives and rational design of a GSH-selective fluorescent probe

Chao Yang, Xiaoqiang Tu, Xiuru Ji, Haishun Ye, Shan Li, Lu Sun, Long Yi and Zhen Xi

Org. Biomol. Chem., 2021, 19, 6527
DOI: 10.1039/D1OB01114F

Indole-substituted flavonol-based cysteine fluorescence sensing and subsequent precisely controlled linear CO liberation

Ying-Ji Sun, Deng-Jie Zhao and Bo Song

Analyst, 2022, 147, 3360
DOI: 10.1039/D2AN00631F

Precise design and synthesis of an AIE-active glutathione fluorescent probe and its exogenous biological imaging

Junxiong Yao, Qian Meng, Han Xu, Changlong Xu, Xiaohua Cao, Huanan Huang, Cuibing Bai and Rui Qiao

Dyes and Pigments, 2023, 218, 111481
DOI: 10.1016/j.dyepig.2023.111481

N‐Aryl‐DABCO Salts as an Unprecedented Sensing Platform for the Detection of Thiols and Selenols

Bahdan Ranishenka, Yuliya Lamekina, Tatsiana Seviarynchyk, Dmitry Bugaenko, Vadim Shmanai and Alexander Karchava

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400229

A novel fluorescent probe based on indole-fused 1,8-naphthalimide derivative for rapid discrimination of H2S, Cys, and Hcy/GSH and its multi-functional applications

Guifen Lu, Sihan Ding, Yaohui Wang, Suci Meng and Yiming Zhang

Dyes and Pigments, 2025, 232, 112494
DOI: 10.1016/j.dyepig.2024.112494

Advances in aggregation-induced emission fluorescent probes for reactive sulfur species detection

Qianqian Zhang, Zezhi Zhang, Jin Liu, Ajuan Song, Chengwei Li, Xiaopeng Yang, Di Zhang and Yong Ye

Coordination Chemistry Reviews, 2026, 547, 217122
DOI: 10.1016/j.ccr.2025.217122

Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells

Renan B. Ferreira, Ling Fu, Youngeun Jung, Jing Yang and Kate S. Carroll

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-33124-z

A versatile fluorescent probe for rapid and ratiometric detection of biogenic amine and its application for food spoilage detection

Wanshuo Luo, Zicen Qiu, Junyan Wei, Anyang Wang, Qinggang Zhang and Haibin Xiao

Microchemical Journal, 2026, 224, 117772
DOI: 10.1016/j.microc.2026.117772

In Situ Selective Determination of Cysteine in Crops Employing a Novel Colorimetric and NIR-Emitting Ratiometric Fluorescent Probe along with a Smartphone-Assisted Portable Detection Device

Xiaodong Chen, Chenglu Zhao, Sanxiu Yang, Yunfei Yang, Yuqing Wang, Rumeng Zhang, Kun Wang, Jing Qian and Lingliang Long

Anal. Chem., 2025, 97, 9291
DOI: 10.1021/acs.analchem.4c07073

Meso-aryltellurium-BODIPY-based fluorescence turn-on probe for selective, sensitive and fast glutathione sensing in HepG2 cells

Qing-Hui Wan, Mingxi Gu, Wen-Jing Shi, Yu-Xin Tang, Yin Lu, Chang Xu, Xiao-Shan Chen, Xin-Tong Wu, Liqian Gao, Dong-Xue Han and Li Niu

Talanta, 2024, 267, 125251
DOI: 10.1016/j.talanta.2023.125251

Single-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis

Daiyu Miao, Qiuning Li, Yi Zhang, Shaojie Qin, Ying Wang, Xiaoyun Liu and Yu Bai

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-70336-z

Research Progress of Multi-signal Fluorescent Probes for Simultaneous Detection of Biothiols

Tiantian Liu, Hongpeng Zhang, Xiaomeng Jiao and Yinjuan Bai

Chinese Journal of Organic Chemistry, 2023, 43, 2081
DOI: 10.6023/cjoc202210034

Concentration-dependent tri-mode morphological evolution of silver nanotriangles for homocysteine enantiomer determination

Fan Wu, Mengyang Zhang, Tongtong Xiong, Xijiao Mu, Bo Liu, Lei Xu, Min Zhang, Junyao Li, Zhaoyin Wang and Zhihui Dai

Talanta, 2025, 295, 128342
DOI: 10.1016/j.talanta.2025.128342

Red and Near-Infrared Fluorescent Probe for Distinguishing Cysteine and Homocysteine through Single-Wavelength Excitation with Distinctly Dual Emissions

Taiyu Guo, Xinyue Chen, Wangbo Qu, Bin Yang, Ruowei Tian, Zhirong Geng and Zhilin Wang

Anal. Chem., 2022, 94, 5006
DOI: 10.1021/acs.analchem.1c04895

A smartphone-available colorimetric and near-infrared fluorescence sensor for trace amounts of water detection in highly polar organic solvents

Zixuan Zhao, Qinghua Hu, Wenjuan Liu, Xuerui Xiong, Zhiyong Wang and Hongqing Wang

Dyes and Pigments, 2023, 213, 111186
DOI: 10.1016/j.dyepig.2023.111186

On-site discrimination of biothiols in biological fluids by a novel fluorescent probe and a portable fluorescence detection device

Lingliang Long, Fang Yuan, Xinrong Yang, Peng Ruan, Xiaodong Chen, Lulu Li, Dan He, Sanxiu Yang, Yunfei Yang and Kun Wang

Sensors and Actuators B: Chemical, 2022, 369, 132211
DOI: 10.1016/j.snb.2022.132211

A bifunctional fluorescent probe based on PET & ICT for simultaneously recognizing Cys and H2S in living cells

Huawei Niu, Yuhan Duan, Yuanyuan Zhang, Xinting Hua, Chuan Xu, Zhaozhou Li, Jinliang Ma, Fangyuan Qin, Yaping Zhai, Yong Ye and Yufen Zhao

Journal of Photochemistry and Photobiology B: Biology, 2022, 230, 112441
DOI: 10.1016/j.jphotobiol.2022.112441

Confined active area and aggregation kinetic-based AuNPs@PVP nanosensors for simultaneous colorimetric detection of cysteine and homocysteine as homologues in human urine and serum

Hua-Li Li, Jie-Ling Liang, Shun-xing Li, Feng-jiao Liu, Jia-Yi Luo, Zhao-Jing Huang, Feng-Ying Zheng, Ling-Ling Su and You-Bin Zhuo

Microchim Acta, 2025, 192
DOI: 10.1007/s00604-025-06962-z

Chromene-based fluorescent probes for sensing and bioimaging

Kaiqing Ma, Lingling Zhao, Yongkang Yue and Caixia Yin

Chemical Physics Reviews, 2022, 3
DOI: 10.1063/5.0058954

Simultaneous Discrimination of Cys/Hcy and GSH With Simple Fluorescent Probe Under a Single-Wavelength Excitation and its Application in Living Cells, Tumor Tissues, and Zebrafish

Dongling Yan, Likun Liu, Xiangbao Liu, Qi Liu, Peng Hou, Hao Wang, Chunhui Xia, Gang Li, Chunhui Ma and Song Chen

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.856994

Concise Biothiol-Activatable HPQ-NBD Conjugate as a Targeted Theranostic Probe for Tumor Cells

Yan Zhang, Caiyun Liu, Weimin Sun, Ziwen Yu, Meijun Su, Xiaodi Rong, Xin Wang, Kun Wang, Xiwei Li, Hanchuang Zhu, Miaohui Yu, Wenlong Sheng and Baocun Zhu

Anal. Chem., 2022, 94, 7140
DOI: 10.1021/acs.analchem.2c01459

Next-Generation Femtech: Urine-Based Cervical Cancer Diagnosis Using a Fluorescent Biothiol Probe with Controlled Smiles Rearrangement

Jong Min An, Minseok Jeong, Junyang Jung, Seung Geun Yeo, Sungnam Park and Dokyoung Kim

ACS Appl. Mater. Interfaces, 2024, 16, 4493
DOI: 10.1021/acsami.3c17050

Equivalent Response Strategy for Sensing Total Biothiols in Human Serums and Living Cells Using a Hemicyanine-Based Self-Immolative Probe

Yijun Gong, Panpan Wang, Hongchen Zhai, Yang Xiao, Qian Wang, Nana Ma, Guisheng Zhang and Hua Zhang

Anal. Chem., 2024, 96, 1009
DOI: 10.1021/acs.analchem.3c02793

Two new rhodamine-based fluorescent probes with thiophen/selenophene acrylate group for selective detection of Cys in living cells

Xiu-Mei Song, Meng-Sen Chen, Shao-Bin Dou, Zhi-Gang Niu and Gao-Nan Li

Tetrahedron, 2024, 158, 133988
DOI: 10.1016/j.tet.2024.133988

Au-mediated Z-scheme TiO2-Au-BiOI photoelectrode for sensitive and selective photoelectrochemical detection of L-cysteine

Yanmei Xin, Zhuo Wang, Haizi Yao, Wanting Liu, Yuqing Miao, Zhonghai Zhang and Dan Wu

Sensors and Actuators B: Chemical, 2023, 393, 134285
DOI: 10.1016/j.snb.2023.134285

An “off-on” fluorescent probe for selective detection of glutathione based on 11-mercaptoundecanoic acid capped gold nanoclusters

Liyun Yang, Yuanping Liao and Zhiqiang Zhou

Optical Materials, 2023, 140, 113867
DOI: 10.1016/j.optmat.2023.113867

A novel turn-on type AIE fluorescent probe for highly selective detection of cysteine/homocysteine and its application in living cells

Wei Wang, Min Ji, Junqing Chen and Peng Wang

Talanta, 2022, 239, 123091
DOI: 10.1016/j.talanta.2021.123091

A simple lysosome-targeted fluorescent probe based on flavonoid for detection of cysteine in living cells

Huiya Tan, Yake Zou, Jiaming Guo, Jiu Chen and Liping Zhou

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 280, 121552
DOI: 10.1016/j.saa.2022.121552

Recent advances in photoelectrochemical detection of hydrogen sulfide

Fang Chen, Xiuhua Wei, Yuanqiang Hao, Yikun Wan, Yintang Zhang and Maotian Xu

International Journal of Electrochemical Science, 2025, 20, 101046
DOI: 10.1016/j.ijoes.2025.101046

Three-Photon AIE Pt(II) Complexes as Cysteine-Targeting Theranostic Agents for Tumor Imaging and Chemotherapy

Zhiyun Fang, Dandan Chen, Jing Xu, Jingmin Wang, Shengli Li, Xiaohe Tian, Yupeng Tian and Qiong Zhang

Anal. Chem., 2022, 94, 14769
DOI: 10.1021/acs.analchem.2c03431

Near-Infrared Probes for Biothiols (Cysteine, Homocysteine, and Glutathione): A Comprehensive Review

Rahul Kaushik, Nidhi Nehra, Veronika Novakova and Petr Zimcik

ACS Omega, 2023, 8, 98
DOI: 10.1021/acsomega.2c06218

Bifunctional fluorescent probe revealing viscosity and SO2 in cell, zebrafish and NASH model

Minrong Huang, Xiaofeng Xia, Zheng Li, Taotao Zhao, Zhengjun Wu, Yong Ren, Jun Ren, Feiyi Wang and Erfei Wang

Analytica Chimica Acta, 2025, 1345, 343740
DOI: 10.1016/j.aca.2025.343740

Rational design of dual-channel response fluorescent probe and its application for highly efficient biothiols imaging in living samples

Keyi Shen, Yazhou Hu, Qiang Fei, Erfei Wang, Jun Ren, Guorun Fan and Feiyi Wang

Journal of Photochemistry and Photobiology A: Chemistry, 2024, 448, 115341
DOI: 10.1016/j.jphotochem.2023.115341

Rational design of a GSH silent fluorescent probe for simultaneous detection of H2S and Cys/Hcy from distinct channels

Xiangbao Liu, Shuang Fu, Hongguang Zhang, Shuang Li, Zhenzhen Zhu, Song Chen, Huiling Hou, Wenqiang Chen and Peng Hou

Microchemical Journal, 2023, 184, 108187
DOI: 10.1016/j.microc.2022.108187

Gold as a coordinator of an imidazole conjugated dye of BODIPY derivatives for the identification of simple mercaptans

Jun Wang, Jin-Ye Lu and Qiu-Yun Chen

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 271, 120912
DOI: 10.1016/j.saa.2022.120912

Visualizing Thiol Stress Responses in Cells with a Water-Soluble Raman Sensor

Hiroyuki Yamakoshi, Meichen Wang, Keisuke Koga, Shinji Kajimoto, Yuse Kuriyama, Yusuke Sasano, Takaaki Akaike, Yoshiharu Iwabuchi and Takakazu Nakabayashi

Anal. Chem., 2025, 97, 25398
DOI: 10.1021/acs.analchem.5c04391

Selenenylsulfide Bond as a General Scaffold for Constructing Thiol Probes with Enhanced Response Rate

Tao Ma, Jintao Zhao, Bingbing Chang, Meirong Yi, Jun Wu, Ruipeng Shen, Xinming Li, Baoxin Zhang and Jianguo Fang

Anal. Chem., 2025, 97, 6629
DOI: 10.1021/acs.analchem.4c06526

An activated near-infrared fluorescent probe with large Stokes shift for discrimination of bio-thiols

Min Zhou, Yanfei Lin, Tianwen Bai, Tianqing Ye, Yanbo Zeng, Lei Li, Zhaosheng Qian, Longhua Guo, Haiying Liu and Jianbo Wang

Sensors and Actuators B: Chemical, 2024, 414, 135994
DOI: 10.1016/j.snb.2024.135994

A facile strategy to construct biocompatible fluorescent nanoparticles for intracellular bioimaging

Nan Wang, Qian Zhou, Xiao-Lin Luo, Yi-Miao Zhang, Kun Li and Xiao-Qi Yu

Polymer, 2024, 290, 126486
DOI: 10.1016/j.polymer.2023.126486

Multi-signal fluorescent probe for simultaneous differentiation and imaging of Hg2+, Cys, Hcy, and GSH in living cells and zebrafish

Yang Li, Jing Li, Ting Yu, Hongyi Cai, Youyu Zhang, Haitao Li, Huijun Zhou and Peng Yin

Journal of Hazardous Materials, 2025, 488, 137427
DOI: 10.1016/j.jhazmat.2025.137427

Recent advances in the study of cysteine-responsive fluorescent probes

Guifen Lu, Sihan Ding, Xiaohan Qiu, Yiming Zhang, Yanmei Ruan and Zhijun Yang

Dyes and Pigments, 2026, 246, 113396
DOI: 10.1016/j.dyepig.2025.113396

Rational design of cascade reaction-assisted trinal-site fluorescent probe for simultaneous discrimination of Cys, Hcy, GSH, and H2S in living cells and zebrafish

Qian Wang, Wenting Zhang, Mingzhe Cai, Yafei Ma, Ajuan Yu, Sheng Chen and Shusheng Zhang

Sensors and Actuators B: Chemical, 2024, 418, 136151
DOI: 10.1016/j.snb.2024.136151

Construction of a unique fluorescent probe for rapid and highly sensitive detection of glutathione in living cells and zebrafish

Zile Zhou, Peijuan Li, Zhihui Liu, Cuiyan Wu, Youyu Zhang and Haitao Li

Talanta, 2022, 243, 123364
DOI: 10.1016/j.talanta.2022.123364

A Cerium Organic Framework with {Cu2I2} Cluster and {Cu2I2}n Chain Modules: Structure and Fluorescence Sensing Properties

Bin Tan, Zi-Wei Li, Zhao-Feng Wu and Xiao-Ying Huang

Sensors, 2023, 23, 2420
DOI: 10.3390/s23052420

A “crossbreeding” dyad strategy for bright and small-molecular weight near-infrared fluorogens: From the structural design to boost aggregation-induced emission

Juan Li, Meiling Zhao, Jialiang Huang, Pengqi Liu, Xinyu Luo, Yutao Zhang, Chenxu Yan, Wei-Hong Zhu and Zhiqian Guo

Coordination Chemistry Reviews, 2022, 473, 214813
DOI: 10.1016/j.ccr.2022.214813

An AIE-active fluorescent probe with near-infrared (NIR) emission for selectively monitoring and bioimaging Cys in living cells

Zhen Zhang, Weijun Zhao, Yun Chen, Sheng-Hao Wei, Fei Zhu, Xu-Zhong Zhu and Cheng-Yun Wang

Tetrahedron, 2023, 140, 133492
DOI: 10.1016/j.tet.2023.133492

Fluorescent detection of tryptophan in physiological media: Potential applications in environmental samples and living systems

Sulekha Kumari Pandit and Gopal Das

Sensors and Actuators B: Chemical, 2024, 417, 136131
DOI: 10.1016/j.snb.2024.136131

Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review

Saman Sargazi, Iqra Fatima, Maria Hassan Kiani, Vahideh Mohammadzadeh, Rabia Arshad, Muhammad Bilal, Abbas Rahdar, Ana M. Díez-Pascual and Razieh Behzadmehr

International Journal of Biological Macromolecules, 2022, 206, 115
DOI: 10.1016/j.ijbiomac.2022.02.137

Visualizing biothiols in vivo using a dual-channel sensitive fluorescent probe

Zixiong Peng, Zheng Li, Tianshuo Zhou, Dian Wu, Erfei Wang, Chao Ma, Cuifen Lu, Junqi Nie, Guorun Fan, Guichun Yang, Feiyi Wang and Jun Ren

Dyes and Pigments, 2023, 214, 111230
DOI: 10.1016/j.dyepig.2023.111230

A 19F‐Labeled Probe for the Chiral Discrimination of Thiols and Thioethers

Jiajin Weng, Guangxing Gu, Wei Zhang, Qi Jia, Yining Sun, Jian Wu and Yanchuan Zhao

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505700

Analyte-Induced Restriction of Intramolecular Rotation: Turn-On aza-BODIPY Sensor for Biothiol Detection in Aqueous Media

Bleda Can Sadikogullari and Ayse Daut Ozdemir

Org. Lett., 2025, 27, 9884
DOI: 10.1021/acs.orglett.5c02543

Development of Nitro-Substituted Pyrido[1,2-a]indole Fluorophores for Environment-Sensitive Bioimaging

Jinju Kim, Taegwan Kim, Ji Soo Kang, Seunghyeon Hwang, Jinjoo Jung, Jongmin Park, Youngjun Lee and Jonghoon Kim

Org. Lett., 2026, 28, 3701
DOI: 10.1021/acs.orglett.6c00141

A novel rhodamine-based fluorescent probe for high selectively determining cysteine in lysosomes

LinKe Li, Qingpu Liu, Runyu Cai, Qiujuan Ma, Guojiang Mao, Nannan Zhu and Shuzhen Liu

Microchemical Journal, 2023, 187, 108449
DOI: 10.1016/j.microc.2023.108449

Accurate Detection of Hcy in Human Serum and Two-Photon Visualization of Atherosclerosis Using a Highly Specific Fluorescent Probe

Feng Wei, Yang Ding, Jiale Ou, Xiaohua Chen, Linke Li, Qiang Zhou, Qi Chen, Qi Wang, Yan Feng and Xiangming Meng

Anal. Chem., 2023, 95, 9173
DOI: 10.1021/acs.analchem.2c05441

A 19F‐Labeled Probe for the Chiral Discrimination of Thiols and Thioethers

Jiajin Weng, Guangxing Gu, Wei Zhang, Qi Jia, Yining Sun, Jian Wu and Yanchuan Zhao

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505700

A simple “turn-on” fluorescent probe capable of recognition cysteine with rapid response and high sensing in living cells and zebrafish

Xiaoyan Cao, Hongzhao Lu, Yifan Wei, Lingxia Jin, Qiang Zhang and Bo Liu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 275, 121167
DOI: 10.1016/j.saa.2022.121167

A Turn-On Fluorescent Amino Acid Sensor Reveals Chloroquine’s Effect on Cellular Amino Acids via Inhibiting Cathepsin L

Michael R. Smith, Le Zhang, Yizhen Jin, Min Yang, Anusha Bade, Kevin D. Gillis, Sadhan Jana, Ramesh Naidu Bypaneni, Timothy E. Glass and Hening Lin

ACS Cent. Sci., 2023, 9, 980
DOI: 10.1021/acscentsci.2c01325

Selection of regioselective DNA aptamer for detection of homocysteine in nondeproteinized human plasma

Jianshuo Zhou, Hui Li, Jinming Li, Xuemei Liu, Jiaxing Zhao, Nan Wang, Yuxiao Wang, Yu Zhang, Xin Zhang, Yucen Xin, Xiaoqi Li, Zheng Wang, Ningsheng Shao and Xinhui Lou

Biosensors and Bioelectronics, 2023, 237, 115528
DOI: 10.1016/j.bios.2023.115528

Molecular Engineering of a Doubly Quenched Fluorescent Probe Enables Ultrasensitive Detection of Biothiols in Highly Diluted Plasma and High-Fidelity Imaging of Dihydroartemisinin-Induced Ferroptosis

Qin Zeng, Zhiyang Yuwen, Lemeng Zhang, Yuning Li, Hongwen Liu and Kai Zhang

Anal. Chem., 2024, 96, 13260
DOI: 10.1021/acs.analchem.4c02431

An Integrated Fluorescent Probe for Ratiometric Detection of Glutathione in the Golgi Apparatus and Activated Organelle-Targeted Therapy

Xiaodi Rong, Caiyun Liu, Mingzhu Li, Hanchuang Zhu, Yan Zhang, Meijun Su, Xin Wang, Xiwei Li, Kun Wang, Miaohui Yu, Wenlong Sheng and Baocun Zhu

Anal. Chem., 2021, 93, 16105
DOI: 10.1021/acs.analchem.1c03836

A site-specific fluorogenic probe for protein disulfide isomerase A1

Yuli Zhuang, Danqi Hong, Wenjie Lang, Yinyan Xuan, Liquan Zhu and Jingyan Ge

Analytical Biochemistry, 2025, 702, 115851
DOI: 10.1016/j.ab.2025.115851

A dicyanoisophorone-based highly selective fluorescent probe with a large stokes shift for cysteine detection in lipid droplets

Yang Zhang, Shan Zhao, Huayu Wang and Chunpo Ge

Journal of Molecular Structure, 2025, 1341, 142684
DOI: 10.1016/j.molstruc.2025.142684

Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability

Jiaojiao Liu, Mei Liu, Fancheng Meng, Jiajia Lv, Mingyan Yang, Jie Gao, Gang Wei, Zeli Yuan and Hongyu Li

ACS Omega, 2022, 7, 46891
DOI: 10.1021/acsomega.2c05997

PyDNA-templated AgNPs coupled with poly (β‑cyclodextrin) enhanced fluorescence: A facile platform for signal amplification detection of biothiols in living cells and zebrafish

Huijuan Yan, Mengxue Liu, Liying Mao, Yuzhen Zhu, XiuLi Yang, Shuo Yang, Zhenghui Wang, Yimiao Xia, Wu Ren, Zhen Jin and Yiqiao Gao

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 330, 125660
DOI: 10.1016/j.saa.2024.125660

Rational Design of Esterase-Insensitive Fluorogenic Probes for In Vivo Imaging

Wu-Yingzheng Guo, Yi-Xuan Fu, Long-Can Mei, Zhao Chen, Zi-Ye Zhang, Fan Wang, Wen-Chao Yang, Guozhen Liu and Guang-Fu Yang

ACS Sens., 2023, 8, 2041
DOI: 10.1021/acssensors.3c00264

A near-infrared self-assembled micellar nanoprobe for highly effective detection of cysteine in vitro and in vivo

Yajie Xu, Hailong Ma, Xianhong Su, Liangtao He, Erfei Wang, Feiyi Wang and Jun Ren

Sensors and Actuators B: Chemical, 2023, 382, 133564
DOI: 10.1016/j.snb.2023.133564

Novel strategy for accurate tumor labeling: endogenous metabolic imaging through metabolic probes

Ying Wen, Zhiqing Long, Fangjun Huo and Caixia Yin

Sci. China Chem., 2022, 65, 2517
DOI: 10.1007/s11426-022-1372-y

A Novel Pyrazoline-Based Fluorescent Turn-On Probe for Biothiol Detection and Live-Cell Imaging

Lei Wang, Lulu Dong, Ruihong Duan and Wenjing Zhang

J Fluoresc, 2026
DOI: 10.1007/s10895-026-04761-0

Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

Yufan Fan, Yue Wu, Jie Hou, Ping Wang, Xiaojun Peng and Guangbo Ge

Coordination Chemistry Reviews, 2023, 480, 215020
DOI: 10.1016/j.ccr.2023.215020

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

Jean‐Elie Zheng, Xavier Franck and Thibault Gallavardin

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500228

GSH responsive traditional clinical drugs probe for cancer cell fluorescence imaging and therapy

Jie Xing, Qiuyu Gong, Ruifen Zou, Junlie Yao, Lingchao Xiang and Aiguo Wu

Chinese Chemical Letters, 2023, 34, 107786
DOI: 10.1016/j.cclet.2022.107786

Selenium: From fluorescent probes to biomedical application

Junping Wang, Mingkai Chen, Zhongyang Zhang, Li Ma and Tianfeng Chen

Coordination Chemistry Reviews, 2023, 493, 215278
DOI: 10.1016/j.ccr.2023.215278

Thiol–Chromene “Click” Reaction-Activated Chemiluminescent Probe for Thiol Detection In Vitro and In Vivo

Baoqu Wang, Xiaoxue Tian, Xing-Cong Li, Kui Cheng and Min Xu

ACS Appl. Mater. Interfaces, 2023, 15, 34505
DOI: 10.1021/acsami.3c05152

A phenylfuran-based near-infrared fluorescence probe for sensitively detecting cysteine in a cellular model of Parkinson's disease

Ya-Long Zheng, Suna Song, Yiran Zhou, Haitao Li, Zhihao Zhu, Yijia Zhang, Zhenhua Song, Zongliang Han, Yuting Wang, Xinyi Yang, Fei Lian, Kai Wei, Fengjuan Yuan and Xianguang Bai

Journal of Molecular Structure, 2025, 1326, 141087
DOI: 10.1016/j.molstruc.2024.141087

Nano-Drug Design Based on the Physiological Properties of Glutathione

Wenhua Li, Minghui Li and Jing Qi

Molecules, 2021, 26, 5567
DOI: 10.3390/molecules26185567

Near-infrared colorimetric and ratiometric fluorescent probe for dual-channel imaging of mitochondria and cysteine in the oxidative stress model

Zhengjun Wu, Dan Zhang, Hailong Ma, Erfei Wang, Feiyi Wang and Jun Ren

Chemical Engineering Journal, 2023, 475, 146397
DOI: 10.1016/j.cej.2023.146397

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes

Wenzhi Xie, Jinyu Jiang, Dunji Shu, Yanjun Zhang, Sheng Yang and Kai Zhang

Molecules, 2023, 28, 4252
DOI: 10.3390/molecules28104252

4-Azidocinnoline—Cinnoline-4-amine Pair as a New Fluorogenic and Fluorochromic Environment-Sensitive Probe

Natalia A. Danilkina, Ekaterina V. Andrievskaya, Anna V. Vasileva, Anna G. Lyapunova, Andrey M. Rumyantsev, Andrey A. Kuzmin, Elena A. Bessonova and Irina A. Balova

Molecules, 2021, 26, 7460
DOI: 10.3390/molecules26247460

A Cys-regulated fluorescent probe targeting cancer cells and their application in inflammation detection

Yukun Zhang, Chen Xu, Hui Sun, Mingguang Ren and Fangong Kong

Journal of Photochemistry and Photobiology A: Chemistry, 2023, 444, 114919
DOI: 10.1016/j.jphotochem.2023.114919

Radical nucleophilic substitution/cyclization: A novel strategy for selective and ultrafast fluorescence imaging of cysteine levels in ferroptosis process

Hanqing Zhao, Yanian Xiong, Liu Zang and Jianzhong Lu

Talanta, 2023, 253, 123917
DOI: 10.1016/j.talanta.2022.123917

Mucus-Inspired Dynamic Hydrogels: Synthesis and Future Perspectives

Raju Bej and Rainer Haag

J. Am. Chem. Soc., 2022, 144, 20137
DOI: 10.1021/jacs.1c13547

A multisite-binding fluorescent probe for simultaneous monitoring of mitochondrial homocysteine, cysteine and glutathione in live cells and zebrafish

Huimin Jiang, Guoxing Yin, Yabing Gan, Ting Yu, Youyu Zhang, Haitao Li and Peng Yin

Chinese Chemical Letters, 2022, 33, 1609
DOI: 10.1016/j.cclet.2021.09.036

Bioimaging and Sensing Thiols In Vivo and in Tumor Tissues Based on a Near-Infrared Fluorescent Probe with Large Stokes Shift

Chunhui Ma, Dongling Yan, Peng Hou, Xiangbao Liu, Hao Wang, Chunhui Xia, Gang Li and Song Chen

Molecules, 2023, 28, 5702
DOI: 10.3390/molecules28155702

A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

Yudi Cheng, Xiao Wang, Jiao Chen, Zihan Zhang, Jiadong Ou, Mengyao She, Fulin Chen and Jianli Li

Chinese Chemical Letters, 2024, 35, 109156
DOI: 10.1016/j.cclet.2023.109156

A highly selective ratio fluorescence probe for detecting cysteine and its bioimaging application

Meng-Min Xiao, Yang-Yang Zhang, Bing-Yu Wei, Yi Zheng, Jun-Ying Miao, Bao-Xiang Zhao and Zhao-Min Lin

Microchemical Journal, 2023, 194, 109243
DOI: 10.1016/j.microc.2023.109243

Investigating Oxidative Stress Associated with Myocardial Fibrosis by High-Fidelity Visualization and Accurate Evaluation of Mitochondrial GSH Levels

Jiale Ou, Hui Tao, Quan Bao, Yuejia Dai, Qi Wang, Qi Chen, Yan Feng and Xiangming Meng

Anal. Chem., 2024, 96, 4232
DOI: 10.1021/acs.analchem.3c05603

General Strategy for Specific Fluorescence Imaging of Homocysteine in Living Cells and In Vivo

Guoxing Yin, Yabing Gan, Huimin Jiang, Ting Yu, Meiling Liu, Youyu Zhang, Haitao Li, Peng Yin and Shouzhuo Yao

Anal. Chem., 2023, 95, 8932
DOI: 10.1021/acs.analchem.3c00799

A Mitochondria‐Targeted Fluorescent and Colorimetric Probe for Sulfur Dioxide Derivatives and Hydrogen Peroxide in Live Cells

Wanting Zhou, Peng Zhang, Fuyan Tang, Wei Shu, Dongpeng Li, Xiaolei Zhang, Yuying Liu and Haibin Xiao

ChemPhotoChem, 2024, 8
DOI: 10.1002/cptc.202300198

Novel near-infrared fluorescent probe with large stokes shift for detection of cysteine in food sample and living cells

Min Zhou, Chunyan Liu, Yanfei Lin, Tianwen Bai, Tianqing Ye, Zhaosheng Qian, Lei Li, Longhua Guo, Haiying Liu and Jianbo Wang

Food Chemistry, 2025, 464, 141755
DOI: 10.1016/j.foodchem.2024.141755

Advances in Coumarin Fluorescent Probes for Medical Diagnostics: A Review of Recent Developments

Katarzyna Szwaczko, Aleksandra Kulkowska and Arkadiusz Matwijczuk

Biosensors, 2026, 16, 36
DOI: 10.3390/bios16010036

A novel NIR fluorescent probe for monitoring cysteine in mitochondria of living cells

Jianning Dong, Guowei Lu, Bin He, Yayi Tu and Congbin Fan

Arabian Journal of Chemistry, 2023, 16, 104765
DOI: 10.1016/j.arabjc.2023.104765

Research on the Application of Fluorescent Probes in Revealing the Mechanism of Cerebral Ischemia-Reperfusion Injury

Yan Shi, Jie Lv, Na Zhou, Fangjun Huo and Caixia Yin

Chemical & Biomedical Imaging, 2026
DOI: 10.1021/cbmi.5c00254

A Golgi-localized fluorescence probe for measuring cysteine based on a naphthalimide derivative

Qiujuan Ma, Junhong Xu, Shuzhen Liu, Guojiang Mao, Shuqi Hou, Yijie Ma and Yujie Lian

Journal of Photochemistry and Photobiology A: Chemistry, 2025, 462, 116276
DOI: 10.1016/j.jphotochem.2025.116276

Selective, Rapid, and Ratiometric Fluorescence Sensing of Homocysteine in Live Neurons via a Reaction-Kinetics/Sequence-Differentiation Strategy Based on a Small Molecular Probe

Yujie Han, Xushan Li, Dong Li, Chen Chen, Qi-Wei Zhang and Yang Tian

ACS Sens., 2022, 7, 1036
DOI: 10.1021/acssensors.1c02684

A fluorescent probe for highly selective detecting of cysteine by steric hindrance effect

Bei Wang, Shuoshuo Wang, Han Zhao, Guiqin Yu and Xiang Liu

Microchemical Journal, 2025, 217, 114793
DOI: 10.1016/j.microc.2025.114793

Chemiluminescence‐driven photoelectrochemical sensor: A mini review

Yuanjian Luo, Yuanqiang Hao, Peisheng Zhang, Yintang Zhang, Rongjin Zeng, Shu Chen and Maotian Xu

Electroanalysis, 2024, 36
DOI: 10.1002/elan.202300257

Fluorescence probes for sensing and imaging within Golgi apparatus

Hui Wang, Xiaoting Zhang, Tiancong Xiu, Hongtong Wang, Ping Li and Bo Tang

Coordination Chemistry Reviews, 2024, 502, 215618
DOI: 10.1016/j.ccr.2023.215618

Fluorescence Probes for Reactive Sulfur Species in Agricultural Chemistry

Xiaoyan Zeng, Weijie Chen, Chunrong Liu, Jun Yin and Guang-Fu Yang

J. Agric. Food Chem., 2021, 69, 13700
DOI: 10.1021/acs.jafc.1c05249

A fluorescent probe capable of naked eye recognition for the selective detection of biothiols

Liuqi Qiao, Yongxing Yang, Yaping Li, Xin Lv and Junsheng Hao

Journal of Photochemistry and Photobiology A: Chemistry, 2022, 425, 113654
DOI: 10.1016/j.jphotochem.2021.113654

A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiols in vivo and in vitro

Taotao Zhao, Tong Zhang, Zijun Tao, Zhe Zhou, Xiaofeng Xia, Zhengjun Wu, Feiyi Wang, Jun Ren and Erfei Wang

iScience, 2024, 27, 111334
DOI: 10.1016/j.isci.2024.111334