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Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein–Protein Interaction

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Synthesis and Antimicrobial Evaluation of Quinoline-Pyrazolone Hybrid Derivatives as Potential Therapeutic Agents

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Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles

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Ethnomedicinal, Phytochemistry and Antiviral Potential of Turmeric (Curcuma longa)

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Electrochemical Approach to Organonitrogen Compounds via C–N Coupling

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Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs

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Synthesis and Cytostatic Activity of Substituted Derivatives of Sodium 1-Amino-2-cyano-1,6-dioxo-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

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Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates

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Advances in Antiviral Strategies for Oral Herpes Infections in Immunocompromised Patients

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Modular Construction of Multivariate Metal–Organic Frameworks for Luminescent Sensing

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Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit

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Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry

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Synthesis and Study of Antimicrobial Activity of Reaction Products of Substituted 3-Thienylimino-3H-furan-2-ones with Substituted Hydrazines and Hydrazides

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An Overview of the Recent Advances in Antimicrobial Resistance

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Molecular docking analysis of peptide-based antiviral agents against SARS-CoV-2 main protease: an approach towards drug repurposing

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Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders

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Decyclization of substituted 3-(4-nitrobenzoyl)hydrasono3H-furan-2-ones under the action of primary alcohols and investigation of analgesic activity and acute toxicity of reaction products

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Synthetic approaches and application of clinically approved small-molecule Anti-HIV drugs: An update

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Recent advances in PROTAC-based antiviral and antibacterial therapeutics

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Revolutionizing viral disease treatment: Phase separation and lysosome/exosome targeting as new areas and new paradigms for antiviral drug research

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Synthesis and study of the hemostatic activity of substituted 5-oxo-1-cyano-3-{(3-cyano-4,5,6,7tetrahydrobenzo[b]thiophen-2-yl)amino{penta-1,3-dien-2-olate potassium

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Exploiting Modeling Studies for Evaluating the Potential Antiviral Activities of some Clinically Approved Drugs and Herbal Materials against SARS-CoV-2: Theoretical Studies toward Hindering the Virus and Blocking the Human Cellular Receptor

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A comprehensive review on targeting cluster of differentiation: An attractive strategy for inhibiting viruses through host proteins

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Revolutionizing antiviral therapy: harnessing nanotechnology to unlock the power of phytoconstituents

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Mechanism of adaptive laboratory evolution for improving polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. through enhancing high-glucose adaptability

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Synthesis and antinociceptive activity of potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates

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Frontiers in superbug management: innovating approaches to combat antimicrobial resistance

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Bibliometric Analysis: Nanotechnology and COVID-19

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Copper iodide decorated graphene oxide as a highly efficient antibacterial and antiviral nanocomposite

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Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP

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Synthesis and antihypoxic activity of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-1H-4,5-dihydropyrrole-3-carboxylic acid derivatives

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The discovery and design of novel HIV-1 capsid modulators and future perspectives

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Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic

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Antiviral activity of Colobanthus quitensis (Kunth) Bartl. natural plant extract against transmissible gastroenteritis coronavirus in vitro

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Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

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Advances in the Rapid Diagnostic of Viral Respiratory Tract Infections

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Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity

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Machine learning techniques applied to the drug design and discovery of new antivirals: a brief look over the past decade

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The Role of Epigallocatechin Gallate (EGCG) in Treatment and Management of Sexually Transmitted Viral Infections

Ozge Yilmaz and Alev Onder

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Therapeutic Inhibitory Activities of N‐Hydroxy Derived Cytidines: A Patent Overview

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ChemistrySelect, 2021, 6, 13786
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Nutritional and pharmacological potentials of the medicinal mushroom Ganoderma adspersum (Schulz.) Donk

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Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury

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Coronaviruses

Claudiu T. Supuran

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Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges

Shaoqing Du, Xueping Hu, Luis Menéndez-Arias, Peng Zhan and Xinyong Liu

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Machine learning and molecular simulation-based protocols to identify novel potential inhibitors for reverse transcriptase against HIV infections

Muhammad Shahab, Guojun Zheng, Yousef A. Bin Jardan and Mohammed Bourhia

Journal of Biomolecular Structure and Dynamics, 2025, 43, 6109
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Synthesis and Hemostatic Activity of Substituted Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates

D. V. Lipin, D. A. Kozlov, V. M. Shadrin, K. Yu. Parkoma, A. V. Starkov, D. A. Shipilovskikh, N. A. Pulina and S. A. Shipilovskikh

Russ J Org Chem, 2023, 59, 1322
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Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

Letian Song, Shenghua Gao, Bing Ye, Mianling Yang, Yusen Cheng, Dongwei Kang, Fan Yi, Jin-Peng Sun, Luis Menéndez-Arias, Johan Neyts, Xinyong Liu and Peng Zhan

Acta Pharmaceutica Sinica B, 2024, 14, 87
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Macrocyclic Compounds: Unveiling Their Distinctive Antiviral Advantages in Medicinal Research

Xiaopei Yang, Zirui Jiao, Chuangchuang Fan, Wenchong Ye, Sai Lv, Xiaoyang Wang, Chunmei Wang, Keyu Zhang, Xisong Ke and Wen Zhou

J. Med. Chem., 2025, 68, 21035
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Synthesis and Analgesic Activity of Substituted N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides

E. I. Denisova, O. V. Zvereva, D. V. Lipin, R. R. Makhmudov, I. N. Chernov, E. S. Denislamova, D. A. Shipilovskikh and N. M. Igidov

Russ J Org Chem, 2024, 60, 2162
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Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation

Da Feng, Hao Lin, Liyang Jiang, Jiaojiao Dai, Xiaoying Zhang, Zhongxia Zhou, Yanying Sun, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

European Journal of Medicinal Chemistry, 2023, 246, 114957
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Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications

Peng Chen, Liang Lou, Bigyan Sharma, Mengchu Li, Chengliang Xie, Fen Yang, Yihang Wu, Qicai Xiao and Liqian Gao

CMC, 2024, 31, 2955
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Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1

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Pharmaceutics, 2023, 15, 2389
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Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity

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Recent advances of novel fourth generation EGFR inhibitors in overcoming C797S mutation of lung cancer therapy

Li Xu, Bing Xu, Jianshe Wang, Yuan Gao, Xingrui He, Tian Xie and Xiang-Yang Ye

European Journal of Medicinal Chemistry, 2023, 245, 114900
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What Have We Learned by Resurrecting the 1918 Influenza Virus?

Brad Gilbertson and Kanta Subbarao

Annual Review of Virology, 2023, 10, 25
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Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity

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Update and latest advances in antiretroviral therapy

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Recent Advances in PROTAC-Based Antiviral Strategies

Haleema Ahmad, Bushra Zia, Hashir Husain and Afzal Husain

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Recent advances in targeted protein degraders as potential therapeutic agents

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From clove oil to bioactive agents: synthetic routes, antimicrobial and antiparasitic activities of eugenol derivatives

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Emerging drug design strategies in anti-influenza drug discovery

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Photosensitizing Antivirals

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Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors

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Emerging affinity methods for protein-drug interaction analysis

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Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents

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Therapeutic cysteine protease inhibitors: a patent review (2018–present)

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The role of ferroptosis in metabolic diseases

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Overcoming Solubility Challenges: Self-emulsifying Systems for Enhancing the Delivery of Poorly Water-Soluble Antiviral Drugs

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Meet the Section Editor

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Conformations and Rearrangements of Collinolactone – Experiments and Theory on a Dynamic Cyclodecatriene

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CTMC, 2024, 24, 2050
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Rational Design of Capsid Protein VP1 Degraders to Overcome Pleconaril Resistance in Inhibiting Enterovirus D68

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JACS Au, 2026
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Antiviral drug discovery and development: challenges and future directions

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Design and Evaluation of Novel HIV-1 Protease Inhibitors Containing Phenols or Polyphenols as P2 Ligands with High Activity against DRV-Resistant HIV-1 Variants

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Different Aspects of Emetine’s Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19

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Design and development of PROTACs: A new paradigm in anticancer drug discovery

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Avian Influenza Virus: Comparative Evolution as the Key for Predicting Host Tropism Expansion

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Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies

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A Nearly 20‐Year Journey to Success of Azvudine for Antiviral Therapy

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Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

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Medicinal chemistry insights into antiviral peptidomimetics

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Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV‐CA Binding Fragments

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Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review)

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Lessons learnt from broad-spectrum coronavirus antiviral drug discovery

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VPS34-mediated autophagosome-lysosome fusion facilitates classical swine fever virus replication

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4′-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives

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Front. Virol., 2025, 5
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Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems

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Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein

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Design, Synthesis, and Biological Activity of Guaiazulene Derivatives

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Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer

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Opportunities and challenges in new HIV therapeutic discovery: what is the next step?

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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

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European Journal of Medicinal Chemistry, 2021, 226, 113848
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Antiviral innovations in largemouth bass aquaculture: Unveiling the potential of arctigenin derivatives against Micropterus Salmoides rhabdovirus

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From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

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MMFA-DTA: Multimodal Feature Attention Fusion Network for Drug-Target Affinity Prediction for Drug Repurposing Against SARS-CoV-2

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Recent Progress in the Discovery of Anti‐Mpox Agents

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Design and synthesis of APN and 3CLpro dual‐target inhibitors based on STSBPT with anticoronavirus activity

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Green Medicine: Advancing Antimicrobial Solutions with Diverse Terrestrial and Marine Plant-Derived Compounds

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Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors

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European Journal of Medicinal Chemistry, 2022, 240, 114563
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Antiviral activity of the HSP90 inhibitor VER-50589 against enterovirus 71

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Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replication

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Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

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Systematic Review of Alkaloids and Their Analogues as Therapeutic Agents for Human Herpesvirus Infection

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Structure-based design of novel 2,4,5-trisubstituted pyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant regions in NNTRIs binding pocket

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European Journal of Medicinal Chemistry, 2025, 289, 117464
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Triple-target small molecule for PRRSV and ASFV infections

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Recent two-year advances in anti-dengue small-molecule inhibitors

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European Journal of Medicinal Chemistry, 2022, 243, 114753
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Exploration of the protein and pharmacological landscape of monkeypox virus treatment: from entry point to end point

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Mol Divers, 2025
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Crossing Boundaries: A Review of the Diverse Functions of Heterocyclic Compounds in the Management of Cancer and Infectious Diseases

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The current progress in the use of boron as a platform for novel antiviral drug design

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HIV-1 Capsid Inhibitors: A Sword to Destroy the Virus

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Phytomedical Properties of Carica papaya for Boosting Human Immunity Against Viral Infections

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A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway

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Acta Pharmaceutica Sinica B, 2026
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Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles

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Meeting report of the 37th International Conference on Antiviral Research in Gold Coast, Australia, May 20–24, 2024, organized by the International Society for Antiviral Research

Stephen R. Welch, John P. Bilello, Kara Carter, Leen Delang, Larissa Dirr, David Durantel, Joy Y. Feng, Brian B. Gowen, Lara J. Herrero, Zlatko Janeba, Gerald Kleymann, Alpha A. Lee, Chris Meier, Jennifer Moffat, Luis M. Schang, Joshua T. Schiffer, Katherine L. Seley-Radtke, Timothy P. Sheahan and Jessica R. Spengler

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Photodynamic Inactivation of Human Herpes Virus In Vitro with Ga(III) and Zn(II) Phthalocyanines

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Viruses, 2024, 16, 1937
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Meet the Editorial Board Member

Peng Zhan

CMC, 2022, 29, 785
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Conformationally Locked Carbocyclic Nucleosides Built on a 4′-Hydroxymethyl-3′-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity

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Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs

Yanying Sun, Zhenzhen Zhou, Da Feng, Lanlan Jing, Fabao Zhao, Zhao Wang, Tao Zhang, Hao Lin, Hao Song, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu and Dongwei Kang

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Ring Opening of Substituted 3-[2-(4-Nitrobenzoyl)hydrazinylidene]furan-2(3H)-ones with Primary Alcohols. Analgesic Activity and Acute Toxicity of the Products

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New use of praziquantel as a broad-spectrum anti-parasitic agent in blocking MSRV infection

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