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Nanotechnology at the crossroads of stem cell medicine
Sweny Jain, Jay Bhatt, Sharad Gupta and Dhiraj Devidas Bhatia
Biomater. Sci., 2025, 13, 161
DOI: 10.1039/D4BM01257G

PET-leveraged ALDH probe toward cancer stem cells
Ji Hyeon Kim, Bryan Yat Kit Hui, Jieun Lee, Kyeong-woo Lee, Jungryun Kim, Yujin Kim, Ming Hui Chua, Jianwei Xu, Min-Goo Lee, Xiaogang Liu and Jong Seung Kim
J. Mater. Chem. B, 2025, 13, 11809
DOI: 10.1039/D5TB01253H

Metal-free synthesis of tricyclic benzofuro[2,3-c]pyridin-3-ol derivatives, characterization, and photoluminescence properties
Surbhi Mahender Saini and Sandeep Chandrashekharappa
RSC Adv., 2025, 15, 31840
DOI: 10.1039/D5RA05420F

Nitroreductase-responsive polymeric micelles based on 4-nitrobenzyl and AIE moieties for intracellular doxorubicin release
Xue-Yi Sun, Ya-Xuan Liang, Cheng-Yan Wu, Quan Tang, Rui Liu, Zhong-Lin Lu and Lan He
Polym. Chem., 2021, 12, 2618
DOI: 10.1039/D1PY00232E

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts
Dung Ngoc Tran, Thi Thuy Hang Hoang, Sondavid Nandanwar, Vuong Thi Thanh Xuan Ho, Van Thong Pham, Huy Duc Vu, Xuan Ha Nguyen, Huy Trung Nguyen, Trang Van Nguyen, Thuy Kieu Van Nguyen, Dai Lam Tran, Myeongkee Park, Songyi Lee and Thanh Chung Pham
RSC Adv., 2023, 13, 36430
DOI: 10.1039/D3RA06555C

Cu(ii)-BODIPY photosensitizer for CAIX overexpressed cancer stem cell therapy
Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan L. Sessler, Jiyou Han and Jong Seung Kim
Chem. Sci., 2023, 14, 1808
DOI: 10.1039/D2SC03945A

Dual-responsive near-infrared turn-on fluorescent probe for cancer stem cell-specific visualization
Koji Miki, Masahiro Oe, Kanae Suzuki, Koki Miki, Huiying Mu, Yoshimi Kato, Mayumi Iwatake, Hiroshi Yukawa, Yoshinobu Baba, Yoshifumi Ueda, Yasuo Mori and Kouichi Ohe
J. Mater. Chem. B, 2024, 12, 6959
DOI: 10.1039/D4TB00897A

ROS activated prodrug for ALDH overexpressed cancer stem cells
Miae Won, Ji Hyeon Kim, Myung Sun Ji and Jong Seung Kim
Chem. Commun., 2022, 58, 72
DOI: 10.1039/D1CC05573A

PTX3 activates POSTN and promotes the progression of glioblastoma via the MAPK/ERK signalling axis
Yuhang Wang, Binbin Wang, Wenping Cao and Xiupeng Xu
Biochemical and Biophysical Research Communications, 2024, 703, 149665
DOI: 10.1016/j.bbrc.2024.149665

Full Color Tunable Aggregation-Induced Emission Luminogen for Bioimaging Based on an Indolizine Molecular Framework
Sang-Kee Choi, Jungi Rho, Sang Eun Yoon, Jin-Hong Seok, Hyungi Kim, Junsik Min, Woojin Yoon, Sanghee Lee, Hoseop Yun, O-Pil Kwon, Jong H. Kim, Wook Kim and Eunha Kim
Bioconjugate Chem., 2020, 31, 2522
DOI: 10.1021/acs.bioconjchem.0c00467

Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer
Hwa-Yong Lee and In-Sun Hong
Cancers, 2020, 12, 2746
DOI: 10.3390/cancers12102746

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species
Jun Dou, Luoyang Li, Mei Guo, Feng Mei, Danfeng Zheng, Hui Xu, Rui Xue, Xueyang Bao, Fengshu Zhao and Yu Zhang
IJN, 2021, Volume 16, 1231
DOI: 10.2147/IJN.S278885

Micropapillary structure: A natural tumor collective invasion model with enhanced stem‐like properties
Sisi Li, Shuangshu Gao, Ling Qin, Caixia Ding, Jinghui Qu, Yifei Cui, Lixia Qiang, Shengjie Yin, Xiaoyu Zheng and Hongxue Meng
Cancer Science, 2025, 116, 308
DOI: 10.1111/cas.16396

Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer
Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang and Qing Bi
Front. Oncol., 2025, 15
DOI: 10.3389/fonc.2025.1503300

Spontaneous upregulation of stemness and 3D spheroid formation of single cancer cells induced by scaffold-free polypeptide polyelectrolyte multilayer coating
Jia-Yang Chen, Chia-Chun Liu, Lucas Wang, Hang-Shiang Jiang, Pei-Syuan Lu, Curtis W. Frank, Mark D. Pegram, Chun-Jen Huang, Yi-Chun Wu, Chin-Lin Guo and Ying-Chih Chang
Biomaterials, 2026, 326, 123702
DOI: 10.1016/j.biomaterials.2025.123702

The potential of cancer stem cells for personalized risk assessment and therapeutic intervention in individuals with intrahepatic cholangiocarcinoma
Jian Zhang, Tao Cui, Jiaobang Xu, Peng Wang, Chongqing Lv and Guozheng Pan
Discov Onc, 2024, 15
DOI: 10.1007/s12672-024-01179-7

Raman spectroscopies for cancer research and clinical applications: a focus on cancer stem cells
Francesca Pagliari, Luca Tirinato and Enzo Di Fabrizio
Stem Cells, 2025, 43
DOI: 10.1093/stmcls/sxae084

Insights on functionalized carbon nanotubes for cancer theranostics
Lu Tang, Qiaqia Xiao, Yijun Mei, Shun He, Ziyao Zhang, Ruotong Wang and Wei Wang
J Nanobiotechnol, 2021, 19
DOI: 10.1186/s12951-021-01174-y

Cancer stem cell‐immune cell collusion in immunotherapy
Yuan‐Yuan Wang, Wen‐Da Wang and Zhi‐Jun Sun
Intl Journal of Cancer, 2023, 153, 694
DOI: 10.1002/ijc.34421

Recent advances in aptamer-based therapeutic strategies for targeting cancer stem cells
Biao Liu, Jiahao Liu, Xing Hu, Wei Xiang, Weibin Hou, Chao Li, Jinrong Wang, Kun Yao, Jin Tang, Zhi Long, Long Wang and Jianye Liu
Materials Today Bio, 2023, 19, 100605
DOI: 10.1016/j.mtbio.2023.100605

Unlocking Natural Potential: Antibody‐Drug Conjugates With Naturally Derived Payloads for Cancer Therapy
Xue Jiang, Wan Najbah Nik Nabil, Yufei Ze, Rongchen Dai, Zhichao Xi and Hongxi Xu
Phytotherapy Research, 2025, 39, 789
DOI: 10.1002/ptr.8407

CD51 promotes gastric cancer stemness via blocking Numb-mediated Notch1 degradation
Juzheng Peng, Yuehan Yin, Xuan Liu, Cuncan Deng, Peizhu Wang, Xiaojie Hu, Jiefu Chen, Sicheng Peng, Kuan Li, Li Zhong, Zhijun Zhou, Yulong He and Jiancheng Wang
Cancer Letters, 2025, 629, 217886
DOI: 10.1016/j.canlet.2025.217886

Roles of lncRNAs Mediating Wnt/β-Catenin Signaling in HCC
Yating Xu, Xiao Yu, Zongzong Sun, Yuting He and Wenzhi Guo
Front. Oncol., 2022, 12
DOI: 10.3389/fonc.2022.831366

The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy
Zixuan Gou, Jiannan Li, Jianming Liu and Na Yang
Front. Cell Dev. Biol., 2024, 12
DOI: 10.3389/fcell.2024.1378302

The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes
Alice Johnson, Xiao Feng, Kuldip Singh, Fabrizio Ortu and Kogularamanan Suntharalingam
Molecules, 2023, 28, 6401
DOI: 10.3390/molecules28176401

Exploring lactylation and cancer biology: insights from pathogenesis to clinical applications
Zixuan Gou, Qianchuang Sun and Jiannan Li
Front. Cell Dev. Biol., 2025, 13
DOI: 10.3389/fcell.2025.1598232

DNA‐Damage‐Response‐Targeting Mitochondria‐Activated Multifunctional Prodrug Strategy for Self‐Defensive Tumor Therapy
Paramesh Jangili, Na Kong, Ji Hyeon Kim, Jun Zhou, Haijun Liu, Xingcai Zhang, Wei Tao and Jong Seung Kim
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202117075

CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9
Tan Du, Zonglong Wu, Yaqian Wu, Yunchong Liu, Yimeng Song and Lulin Ma
Biomedicines, 2023, 11, 2077
DOI: 10.3390/biomedicines11072077

Notch3 mediated TGF‑β1 activation enhances epithelial‑mesenchymal transition and cancer stemness in non‑small lung cancer
Fang Wang, Siqi Hu, Jiangrong Bian, Qing Gao, Liuzhao Cao, Linli Sang, Junjun Yang and Xingxiang Xu
Int J Oncol, 2025, 67, 1
DOI: 10.3892/ijo.2025.5791

Cancer Stem‐Like Cells‐Oriented Surface Self‐Assembly to Conquer Radioresistance
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren and Jianfeng Liu
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202302916

A dual-action niclosamide-based prodrug that targets cancer stem cells and inhibits TNBC metastasis
Ji Hyeon Kim, Soeun Park, Eunsun Jung, Jinwoo Shin, Yoon-Jae Kim, Ji Young Kim, Jonathan L. Sessler, Jae Hong Seo and Jong Seung Kim
Proc. Natl. Acad. Sci. U.S.A., 2023, 120
DOI: 10.1073/pnas.2304081120

Targeting the glutamine-arginine-proline metabolism axis in cancer
Di Wang, Jiang-jie Duan, Yu-feng Guo, Jun-jie Chen, Tian-qing Chen, Jun Wang and Shi-cang Yu
Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39
DOI: 10.1080/14756366.2024.2367129

N6‐methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer
Jiayao Wang, Jiehao Zhang, Hao Liu, Lingnan Meng, Xianchun Gao, Yihan Zhao, Chen Wang, Xiaoliang Gao, Ahui Fan, Tianyu Cao, Daiming Fan, Xiaodi Zhao and Yuanyuan Lu
Cancer Commun, 2024, 44, 469
DOI: 10.1002/cac2.12534

LAPTM4B enhances the stemness of CD133+ liver cancer stem-like cells via WNT/β-catenin signaling
Jiahong Wang, Jianping Liao, Ye Cheng, Meirong Chen and Aimin Huang
JHEP Reports, 2025, 7, 101306
DOI: 10.1016/j.jhepr.2024.101306

Preclinical evaluation of 68Ga‐labeled peptides for targeting CD44 imaging
Xiaoyu Pan, Yi Liu, Xuwei Liu, Fengsheng Zhang, Liyan Bai, Yue Xi, Mengjing Ji, Xiaoping Xu, Fei Liu, Jindian Li and Shaoli Song
VIEW, 2025, 6
DOI: 10.1002/VIW.20240081

Roles of selenium-containing glutathione peroxidases and thioredoxin reductases in the regulation of processes associated with glioblastoma progression
Elena G. Varlamova
Archives of Biochemistry and Biophysics, 2025, 766, 110344
DOI: 10.1016/j.abb.2025.110344

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui and Zhenke Wen
Advanced Science, 2026, 13
DOI: 10.1002/advs.202513535

Cutting Off H+ Leaks on the Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells
Minsu Park, Kyoung Sunwoo, Yoon-Jae Kim, Miae Won, Yunjie Xu, Jaewon Kim, Zhongji Pu, Mingle Li, Ji Young Kim, Jae Hong Seo and Jong Seung Kim
J. Am. Chem. Soc., 2023, 145, 4647
DOI: 10.1021/jacs.2c12587

Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies
Wei Xie, Jingjing Fang, Zhen Wang, Xia Li, Juan Du and Changquan Ling
Cancer Gene Ther, 2026
DOI: 10.1038/s41417-026-01007-w

Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades
Hailang Fan, Lairong Song, Jian Fan, Junpeng Ma, Xiaojie Li, Junting Zhang, Jian Hu, Zhen Wu, Dake Zhang and Liang Wang
J Transl Med, 2023, 21
DOI: 10.1186/s12967-023-04445-4

Advancements in colorectal cancer detection: The role of immuno‐positron emission tomography, immuno‐single‐photon emission computed tomography, and machine learning applications
Surui Chen, Xiumin Shi, Shu Liu, Pei Pei, Kai Yang and Lin Hu
Journal of Intelligent Medicine, 2024, 1, 63
DOI: 10.1002/jim4.16

Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells
Kuan Hu, Xiaohui Ma, Lin Xie, Yiding Zhang, Masayuki Hanyu, Honoka Obata, Lulu Zhang, Kotaro Nagatsu, Hisashi Suzuki, Rui Shi, Weizhi Wang and Ming-Rong Zhang
ACS Omega, 2022, 7, 334
DOI: 10.1021/acsomega.1c04711

Effect of microserum environment stimulation on extraction and biological function of colorectal cancer stem cells
Feiqing Wang, Jianing Zhao, Chike Zhang, Bo Yang, Tingting Tian, Mengxian Tian, Na Meng, Wei Xie, Guangyang Liu, Xiaodong Zhu, Min Su, Zhixu He, Yang Liu, Dongxin Tang and Yanju Li
Discov Onc, 2023, 14
DOI: 10.1007/s12672-023-00779-z

The Capacity of Drug-Metabolising Enzymes in Modulating the Therapeutic Efficacy of Drugs to Treat Rhabdomyosarcoma
Enric Arasanz Picher, Muhammad Wahajuddin, Stefan Barth, Julia Chisholm, Janet Shipley and Klaus Pors
Cancers, 2024, 16, 1012
DOI: 10.3390/cancers16051012

Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment
Chiwei CHEN, Renlun HUANG, Neng WANG, Yifeng ZHENG, Jianfu ZHOU, Bowen YANG, Xuan WANG, Juping ZHANG, Bo PAN, Zhiqiang CHEN, Shengqi WANG, Zhiyu WANG and Songtao XIANG
Chinese Journal of Natural Medicines, 2024, 22, 501
DOI: 10.1016/S1875-5364(24)60653-9

Targeting drug‐tolerant cells: A promising strategy for overcoming acquired drug resistance in cancer cells
Xiaohai Song, Yang Lan, Xiuli Zheng, Qianyu Zhu, Xuliang Liao, Kai Liu, Weihan Zhang, QiangBo Peng, Yunfeng Zhu, Linyong Zhao, Xiaolong Chen, Yang Shu, Kun Yang and Jiankun Hu
MedComm, 2023, 4
DOI: 10.1002/mco2.342

Trapped in Cells: A Selective Accumulation Approach for Type-I Photodynamic Ablation of Cancer Stem–like Cells
Ji Hyeon Kim, Jieun Lee, Kyung-Woo Lee, Hao Xiong, Mingle Li and Jong Seung Kim
JACS Au, 2024, 4, 3657
DOI: 10.1021/jacsau.4c00642

ADVANCING CANCER TREATMENT: STEM CELL THERAPIES AND BIOIMAGING INNOVATIONS
Nour Elamal Elashhab and Amna Ejbarah
JBS, 2024, 37, 54
DOI: 10.59743/jbs.v37i1.257

SLC4A7 suppresses lung adenocarcinoma oncogenesis by reducing lactate transport and protein lactylation
Haojie Yan, Qian He, Yubiao Gao, Xiaomei He, Haitao Luo, Lijuan Shao, Jun Dong and Furong Li
Int J Oncol, 2025, 66, 1
DOI: 10.3892/ijo.2025.5739

Tumor Microenvironment Metabolism‐Modulating Nanomedicines for Enhancing Anti‐Tumor Immunity
Jiajie Chen, Simiao Fei, Zhihao Cao, Xinchun Liu, Weizhi Ji, Hangrong Chen, Yuyu Niu and Zebin Yang
Small, 2025, 21
DOI: 10.1002/smll.202509685

VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
Yun Yuan, Xu-Fan Zhang, Yu-Chen Li, Hong-Qing Chen, Tian Wen, Jia-Lian Zheng, Zi-Yi Zhao and Qiong-Ying Hu
World J Stem Cells, 2024, 16, 207
DOI: 10.4252/wjsc.v16.i2.207

Therapeutic potential of tLyp-1-EV-shCTCF in inhibiting liver cancer stem cell self-renewal and immune escape via SALL3 modulation in hepatocellular carcinoma
Heng Zhu and Zhihui Xie
Translational Oncology, 2024, 49, 102048
DOI: 10.1016/j.tranon.2024.102048

Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors
Hao Zhang, Shenglong Li, Chongzhong Liu, Xiangdong Gongye, Han Li, Yiyi Ji, Cheng-Wei Ju, Wenzhen Jia, Xing Niu, Yujing Guan, Xiangyu Zhai, Bin Jin and Peng Xia
Cell Reports Medicine, 2026, 7, 102545
DOI: 10.1016/j.xcrm.2025.102545

IL-24 improves efficacy of CAR-T cell therapy by targeting stemness of tumor cells
Kai Zhang, Wenhao Hu, Feng Li, Chunli Wen, Lingxiao Zhou, Lei Zhang, Jingyao Lian, Shasha Liu, Shumin Wang and Yi Zhang
Br J Cancer, 2024, 130, 1337
DOI: 10.1038/s41416-024-02601-1

Single-cell transcriptomic landscape highlights epithelial-fibroblast interactions and CD44-mediated malignant traits in laryngeal squamous cell carcinoma
Meng Jin, Xin Wang, Lingmei Qu, Zhaonan Xu, Shuo Liu, Shuang Teng, Fengshuo Zhang, Qing Hao, Peng Wang, Rui Zhao, Jingyuan Ren, Bingrui Yan and Yanan Sun
npj Precis. Onc., 2026
DOI: 10.1038/s41698-026-01431-z

XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression
Wei-Qiang Yang, Wei-Jun Zhao, Liu-Lian Zhu, Shuai-Jun Xu, Xue-Lin Zhang, Yong Liang, Xiao-Fei Ding, Alexander Kiselyov and Guang Chen
Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.603453

A platinum(II) complex HY1-Pt overcomes cisplatin-induced resistance and attenuates metastasis of epithelial ovarian cancer by cancer cell stemness inhibition
Xinyi Wang, Yuanjiang Wang and Shaohua Gou
The International Journal of Biochemistry & Cell Biology, 2023, 157, 106395
DOI: 10.1016/j.biocel.2023.106395

CD133 expression is associated with less DNA repair, better response to chemotherapy and survival in ER-positive/HER2-negative breast cancer
Takumi Sato, Masanori Oshi, Jing Li Huang, Kohei Chida, Arya Mariam Roy, Itaru Endo and Kazuaki Takabe
Breast Cancer Res Treat, 2024, 208, 415
DOI: 10.1007/s10549-024-07434-3

Advances in Nanomedicine for Targeting Cancer Stem Cells and Overcoming Therapeutic Resistance
Zhan Zhang, Bangye Chen, Yanchen Liu, Kai Zhang, Zihao Wei, Yunlu Dai and Caigang Liu
ACS Nano, 2025, 19, 30720
DOI: 10.1021/acsnano.5c02321

Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer
Peng Zhao, Jianfei Qiu, Chaolan Pan, Yunyan Tang, Meijun Chen, Hui Song, Jue Yang and Xiaojiang Hao
Phytomedicine, 2023, 114, 154810
DOI: 10.1016/j.phymed.2023.154810

Self-Activating Therapeutic Nanoparticle: A Targeted Tumor Therapy Using Reactive Oxygen Species Self-Generation and Switch-on Drug Release
Rae Hyung Kang, Yumi Kim, Ji Hyeon Kim, Na Hee Kim, Hyun Min Ko, Seung-Hyeon Lee, Inseob Shim, Jong Seung Kim, Hyeung-Jin Jang and Dokyoung Kim
ACS Appl. Mater. Interfaces, 2021, 13, 30359
DOI: 10.1021/acsami.1c07037

Supramolecular Fluorescent Probes for the Detection of Reactive Oxygen Species Discovered via High-Throughput Screening
Siyang Jiang, Jingyu Yang, Li Ling, Shuyi Wang and Da Ma
Anal. Chem., 2022, 94, 5634
DOI: 10.1021/acs.analchem.1c05647

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy
Min Jun Ko, Hyunsik Hong, Hyunjun Choi, Heemin Kang and Dong‐Hyun Kim
Advanced NanoBiomed Research, 2022, 2
DOI: 10.1002/anbr.202200053

RXR signaling targeted cancer therapy
Wenrui Zhao, Suyao Li, Ruoxue Chen, Junjie Ni, Xuan Huang, Song Li, Xiaoling Lu and Xin Cao
TIL, 2023, 1, 100014
DOI: 10.59717/j.xinn-life.2023.100014

New Perspectives in Different Gene Expression Profiles for Early and Locally Advanced Non-Small Cell Lung Cancer Stem Cells
Valentina Masciale, Federico Banchelli, Giulia Grisendi, Roberto D’Amico, Antonino Maiorana, Alessandro Stefani, Uliano Morandi, Massimo Dominici and Beatrice Aramini
Front. Oncol., 2021, 11
DOI: 10.3389/fonc.2021.613198

An Abdominal Registration Technology for Integration of Nanomaterial Imaging-Aided Diagnosis and Treatment
Shao-Di Yang, Yu-Qian Zhao, Fan Zhang, Miao Liao, Zhen Yang, Yan-Jin Wang and Ling-Li Yu
j biomed nanotechnol, 2021, 17, 952
DOI: 10.1166/jbn.2021.3076

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy
Wenhao Liao, Yuchen Li, Jing Wang, Maoyuan Zhao, Nianzhi Chen, Qiao Zheng, Lina Wan, Yu Mou, Jianyuan Tang and Zhilei Wang
IJN, 2022, Volume 17, 4163
DOI: 10.2147/IJN.S380697

Polypyrrole-iron phosphate-glucose oxidase-based nanocomposite with cascade catalytic capacity for tumor synergistic apoptosis-ferroptosis therapy
Luen Xu, Jianxin Wang, Jingjing Wang, Shi-Yu Lu, Qiang Yang, Chunmei Chen, Huawei Yang, Fengqiu Hong, Changjun Wu, Qingliang Zhao, Yang Cao and Hui Liu
Chemical Engineering Journal, 2022, 427, 131671
DOI: 10.1016/j.cej.2021.131671

Tumor‐Activated Prodrug with Synergistic Anti‐Stemness Chemical and Photodynamic Therapies
Jianhua Xiong, Xiaoyu Wang, Jaewon Kim, Jiankang Gong, Zhiqiang Mao, Jong Seung Kim and Zhihong Liu
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202312590

Label-free tumor cell screening based on IDO1-mediated tryptophan metabolism at single cell level
Huimin Zhou, Huilin Wen, Lancheng Wang, Mingjie Xu, Yan Jia, Shiqi Duan, Bin Di, Ziyi Yu and Chi Hu
Analytical Biochemistry, 2022, 659, 114936
DOI: 10.1016/j.ab.2022.114936

The missing link between cancer stem cells and immunotherapy
Lobna Safwat Ali, Youssef A. M. Attia, Sohaila Mourad, Esraa M. Halawa, Noreen H. Abd Elghaffar, Seham Shokry, Omar M. Attia, Maha Makram, Al-Hassan Soliman Wadan, Walaa A. Negm and Engy Elekhnawy
Current Medical Research and Opinion, 2024, 40, 1963
DOI: 10.1080/03007995.2024.2407963

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM
Viktorija Juric, Heiko Düssmann, Martine L. M. Lamfers, Jochen H. M. Prehn, Markus Rehm and Brona M. Murphy
Cells, 2021, 10, 1182
DOI: 10.3390/cells10051182

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology
Taiki Miyazawa, Mayuko Itaya, Gregor C Burdeos, Kiyotaka Nakagawa and Teruo Miyazawa
IJN, 2021, Volume 16, 3937
DOI: 10.2147/IJN.S298606

A Focus on “Bio” in Bio–Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions
Christina Cortez‐Jugo, Ewa Czuba‐Wojnilowicz, Abigail Tan and Frank Caruso
Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100574

Stem cell and organoid modeling in cancer study
Tingyi Li
HSET, 2025, 129, 171
DOI: 10.54097/30jjys67

Nanotherapeutic strategies exploiting biological traits of cancer stem cells
Hongyu Wang, Wenjing Zhang, Yun Sun, Xican Xu, Xiaoyang Chen, Kexu Zhao, Zhao Yang and Huiyu Liu
Bioactive Materials, 2025, 50, 61
DOI: 10.1016/j.bioactmat.2025.03.016

Nanomaterial-mediated ablation therapy for cancer stem cells
Yuanwei Pan, Lujie Liu, Lang Rao and Xiaoyuan Chen
Matter, 2022, 5, 1367
DOI: 10.1016/j.matt.2022.02.015

Enhancement of Fluorescence Mediated by Silver Nanoparticles: Implications for Cell Imaging
Pradip Maiti, Swarupa Sarkar, Tanmoy Singha, Sannak Dutta Roy, Mrityunjoy Mahato, Parimal Karmakar, Sharmistha Paul and Pabitra Kumar Paul
Langmuir, 2023, 39, 6713
DOI: 10.1021/acs.langmuir.3c00204

Tumor Abnormality-Oriented Nanomedicine Design
Quan Zhou, Jiajia Xiang, Nasha Qiu, Yechun Wang, Ying Piao, Shiqun Shao, Jianbin Tang, Zhuxian Zhou and Youqing Shen
Chem. Rev., 2023, 123, 10920
DOI: 10.1021/acs.chemrev.3c00062

Heterocyclic Molecular Targeted Drugs and Nanomedicines for Cancer: Recent Advances and Challenges
Junxia Liu, Tengfei Chao, Yingying Liu, Chen Gong, Yinan Zhang and Huihua Xiong
Pharmaceutics, 2023, 15, 1706
DOI: 10.3390/pharmaceutics15061706

Effective identification and differential analysis of anticancer peptides
Lichao Zhang, Xueli Hu, Kang Xiao and Liang Kong
BioSystems, 2024, 241, 105246
DOI: 10.1016/j.biosystems.2024.105246

ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
Hua Shao, Hanlu Tang, Huiying Lin and Yongqing Xu
BMC Med, 2026, 24
DOI: 10.1186/s12916-025-04614-w

Hydroxyethyl starch-folic acid conjugates stabilized theranostic nanoparticles for cancer therapy
Chong Wang, Qiang Wang, Huimin Wang, Zheng Li, Jitang Chen, Zhijie Zhang, Haowen Zeng, Ximiao Yu, Xiaoquan Yang, Xiangliang Yang and Zifu Li
Journal of Controlled Release, 2023, 353, 391
DOI: 10.1016/j.jconrel.2022.11.059

Next‐Generation Cancer Theragnostic: Applications of Carbon Quantum Dots
Ankesh Kumar, Dhruvi Dipakbhai Patel, Juni Banerjee, Manasvi Sharma, Dhiraj Bhatia, Shuvomoy Banerjee and Amit Kumar Yadav
ChemNanoMat, 2025, 11
DOI: 10.1002/cnma.202500061

Loss of ATOH1 in Pit Cell Drives Stemness and Progression of Gastric Adenocarcinoma by Activating AKT/mTOR Signaling through GAS1
Qing Zhong, Hua‐Gen Wang, Ji‐Hong Yang, Ru‐Hong Tu, An‐Yao Li, Gui‐Rong Zeng, Qiao‐Ling Zheng, Zhi‐ Yu Liu, Zhi‐Xin Shang‐Guan, Xiao‐ Bo Huang, Qiang Huang, Yi‐Fan Li, Hua‐Long Zheng, Guang‐Tan Lin, Ze‐Ning Huang, Kai‐Xiang Xu, Wen‐Wu Qiu, Mei‐Chen Jiang, Ya‐Jun Zhao, Jian‐Xian Lin, Zhi‐Hong Huang, Jing‐Min Huang, Ping Li, Jian‐Wei Xie, Chao‐Hui Zheng, Qi‐Yue Chen and Chang‐Ming Huang
Advanced Science, 2023, 10
DOI: 10.1002/advs.202301977

Primary colorectal cancer cells cultured in hydrogel microcapsules-integrated microfluidic chip for chemotherapy evaluation
Chuanmeng Pan, Xiang Lin, Feika Bian, Liqun Li and Xian Shen
Chemical Engineering Journal, 2025, 519, 164173
DOI: 10.1016/j.cej.2025.164173

Tumor Microenvironment-Responsive Nanoherb Delivery System for Synergistically Inhibition of Cancer Stem Cells
Yuanyuan Jia, Jia Sun, Jingjing Yang, Chao Chen, Zhenyu Zhang, Kaiyong Yang, Peiliang Shen, Suchen Qu, Bangshun He, Yanni Song and Xin Han
ACS Appl. Mater. Interfaces, 2023, 15, 16329
DOI: 10.1021/acsami.2c19029

Co‐assembled Manganese‐CpG Nanoliposomes for Enhanced Immunotherapy against Colon Cancer Stem Cells
Weijian Zhao, Siyu Sun, Xuesong He, Yiran Liu, Jing Meng, Qin Hu, Wang Sheng and Runqing Jia
Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202500545

An overview of current research on cancer stem cells: a bibliometric analysis
Xueyang Zhang, Wenbo Du, Xizhi Huang, Haoting Zhong and Ning Hu
Clin Transl Oncol, 2024, 26, 2466
DOI: 10.1007/s12094-024-03486-5

Interpretation of the Transcriptome-Based Signature of Tumor-Initiating Cells, the Core of Cancer Development, and the Construction of a Machine Learning-Based Classifier
Seung-Hyun Jeong, Jong-Jin Kim, Ji-Hun Jang and Young-Tae Chang
Cells, 2025, 14, 1255
DOI: 10.3390/cells14161255

NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells
Somya Ranjan Dash, Subhajit Chatterjee, Saptarshi Sinha, Biswajit Das, Subarno Paul, Rajalaxmi Pradhan, Chinmayee Sethy, Rupayana Panda, Jasaswini Tripathy and Chanakya Nath Kundu
Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 40, 102502
DOI: 10.1016/j.nano.2021.102502

Efficient and Discriminative Isolation of Circulating Cancer Stem Cells and Non-Stem-like Circulating Tumor Cells Using a Click-Handle-Loaded M13 Phage-Based Surface
Huida Li, Fengting Jia, Xin Wang, Ting Yang and Jian-Hua Wang
Anal. Chem., 2025, 97, 8080
DOI: 10.1021/acs.analchem.5c00924

Smart hydrogels for overcoming cancer multidrug resistance
Yong Wang, Baoyan Liu, Zou-Fang Huang, Harsh Patel, Jinming Yu, Man Hu and Zhe-Sheng Chen
Mol Cancer, 2026
DOI: 10.1186/s12943-026-02660-3

CD71/CD44 dual-aptamer-gemcitabine conjugate for tumor co-targeting treatment of bladder cancer
Biao Liu, Jinrong Wang, Yongbo Peng, Hongliang Zeng, Qun Zhang, Minhua Deng, Wei Xiang, Jiahao Liu, Xing Hu, Xuewen Liu, Jianfei Xie, Weibin Hou, Jin Tang, Zhi Long, Long Wang and Jianye Liu
Chemical Engineering Journal, 2023, 464, 142597
DOI: 10.1016/j.cej.2023.142597

The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer
Ying Yang, Wen-Jian Meng and Zi-Qiang Wang
Front. Oncol., 2022, 12
DOI: 10.3389/fonc.2022.960539

Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Zhengyue Zhang and Yanjie Zhang
J Exp Clin Cancer Res, 2024, 43
DOI: 10.1186/s13046-024-03021-y

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells
Changshun Zhao, Wei Wang, Zhengchun Huang, Yuqing Wan, Rui Xu, Junmei Zhang, Bingbing Zhao, Ke Wang, Suchen Wen, Yinan Zhong, Dechun Huang and Wei Chen
Acta Pharmaceutica Sinica B, 2025, 15, 5458
DOI: 10.1016/j.apsb.2025.08.001

Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications
Ji-Ting Hou, Nahyun Kwon, Shan Wang, Bingya Wang, Xiaojun He, Juyoung Yoon and Jianliang Shen
Coordination Chemistry Reviews, 2022, 450, 214232
DOI: 10.1016/j.ccr.2021.214232

Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms
Huan Zhao, Bing Han, Xuan Li, Chengtao Sun, Yufei Zhai, Man Li, Mi Jiang, Weiping Zhang, Yi Liang and Guoyin Kai
Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.872085

Based on network pharmacology and experiments to investigate the inhibitory effect of Licoricesaponin G2 on lung cancer tumor growth
Xu Yang, Jian-hui Xiao, Xiang Li, Ru-ming Liu and Qing Yuan
Journal of Ethnopharmacology, 2026, 357, 120950
DOI: 10.1016/j.jep.2025.120950

CRISPR screening in cancer stem cells
Stephanie Ma, Terence Lee, Bei Wang and Alan S.L. Wong
Essays in Biochemistry, 2022, 66, 305
DOI: 10.1042/EBC20220009

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li and Zhiwen Zhang
J Nanobiotechnol, 2021, 19
DOI: 10.1186/s12951-021-01143-5

Wavelength engineerable porous organic polymer photosensitizers with protonation triggered ROS generation
Jinwoo Shin, Dong Won Kang, Jong Hyeon Lim, Jong Min An, Youngseo Kim, Ji Hyeon Kim, Myung Sun Ji, Sungnam Park, Dokyoung Kim, Jin Yong Lee, Jong Seung Kim and Chang Seop Hong
Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-37156-x

Engineered Extracellular Vesicles for Cancer Stem Cell Theranostics: Recent Advances and Future Perspectives
Mustafa Abdullah, Waleed K. Abdulsahi, Wael Waleed Mustafa, S. Renuka Jyothi, Priya Priyadarshini Nayak, J. Bethanney Janney, Gurjant Singh, Aashna Sinha and Obid Khamidov
Stem Cell Rev and Rep, 2026, 22, 1225
DOI: 10.1007/s12015-026-11064-1

Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review
Abolfazl Doustmihan, Marziyeh Fathi, MirAhmad Mazloomi, Aysan Salemi, Michael R. Hamblin and Rana Jahanban-Esfahlan
Journal of Controlled Release, 2023, 363, 57
DOI: 10.1016/j.jconrel.2023.09.029

Photocatalytic detoxification of a sulfur mustard simulant under realistic conditions by imidazoline-based porous organic polymer composites
Hyojin Kim, Jinwoo Shin, Dong Won Kang, Youngseo Kim, Ji Hyeon Kim, Minjung Kang, Jong Hyeak Choe, Sungnam Park, Jong Seung Kim and Chang Seop Hong
Cell Reports Physical Science, 2022, 3, 100888
DOI: 10.1016/j.xcrp.2022.100888

The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance
Lina Alhaddad, Andreyan N. Osipov and Sergey Leonov
IJMS, 2022, 23, 13577
DOI: 10.3390/ijms232113577

Heteronuclear Single‐Atom Nanozymes Overcome Radiotherapy Resistance via Synergistic Multi‐Enzyme Activities
Bowen Yang, Yiyin Mai, Hongyan Su, Ruonan Li, Ge Qiao, Jiannan Wu, Pingyu Zhang, Hanqing Chen, Tingting Wang, Guotao Yuan and Yue Pan
Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202527017

Genome-wide identification of alternative splicing related with transcription factors and splicing regulators in breast cancer stem cells responding to fasting-mimicking diet
Hongshuang Qin, Qian Zhang and Yanxiang Guo
Computational Biology and Chemistry, 2024, 113, 108272
DOI: 10.1016/j.compbiolchem.2024.108272

Aptamer-based NIR II imaging for breast cancer surgical resection
Lei Niu, Kang-Liang Lou, Zhi Zhu, Wei-Zhi Liu, Wen-Liang Gao, Gu-Yue Hu, Jun-Xue Gao, Guo-Jun Zhang and Wen-He Huang
npj Imaging, 2025, 3
DOI: 10.1038/s44303-025-00095-x

Machine learning methods revealed the roles of immune-metabolism related genes in immune infiltration, stemness, and prognosis of neuroblastoma
Jianhua Mu, Jianan Gong, Peng Lin, Mengzhen Zhang and Kai Wu
CBM, 2023, 38, 241
DOI: 10.3233/CBM-230119

Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective
Yongquan Tang, Yan Chen, Zhe Zhang, Bo Tang, Zongguang Zhou and Haining Chen
Pharmaceutics, 2021, 13, 2116
DOI: 10.3390/pharmaceutics13122116

Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment
Bowen Li, Jianwu Tian, Fu Zhang, Chongzhi Wu, Zhiyao Li, Dandan Wang, Jiahao Zhuang, Siqin Chen, Wentao Song, Yufu Tang, Yuan Ping and Bin Liu
Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-53771-8

In vitro investigation of epigenetic regulators related to chemo-resistance and stemness of CD133+VE cells sorted from U87MG cell line
Elham Abusharieh, Nazneen Aslam, Malek A. Zihlif, Yasser Bustanji, Suha Wehaibi, Duaa Abuarqoub, Diana Shahin, Heba Saadeh, Raghad Barham and Abdalla S. Awidi
Gene, 2025, 956, 149432
DOI: 10.1016/j.gene.2025.149432

Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models
Xi Lei, Yi Wang, Yuanyuan Chen, Jinyue Duan, Xin Gao and Zhongyi Cong
Molecules, 2025, 30, 2377
DOI: 10.3390/molecules30112377

Time-Resolved Quantification of Single-Cell Extracellular Vesicles Secretion for Drug Resistance Evaluation
Haimeng Pei, Haibin Si, Dexin Du, Lu Li and Bo Tang
Anal. Chem., 2025, 97, 15753
DOI: 10.1021/acs.analchem.5c01558

Human Glioblastoma Visualization: Triple Receptor-Targeting Fluorescent Complex of Dye, SIWV Tetra-Peptide, and Serum Albumin Protein
Jong Min An, Heejo Moon, Peter Verwilst, Jinwoo Shin, B. Moon Kim, Chul-Kee Park, Jong Seung Kim, Seung Geun Yeo, Hyo Young Kim and Dokyoung Kim
ACS Sens., 2021, 6, 2270
DOI: 10.1021/acssensors.1c00320

Overcoming Chemoresistance via an AIEgen-Based Covalent Organic Framework
An Song, Qing Wang, Bo-Yu Liu, Qi-Chao Yang, Zi-Yan Hu, Heng-Tao Lei, Xiao-Long Zhang, Fang-Ling Gao, Wu-Yin Wang, Meng-Jie Zhang, Shuo Wang, Tian-Fu Wu, Liang Zhang and Zhi-Jun Sun
Nano Lett., 2026, 26, 1662
DOI: 10.1021/acs.nanolett.5c05157

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang and Bixiang Zhang
Exp Hematol Oncol, 2022, 11
DOI: 10.1186/s40164-022-00352-4

Iron metabolism: backfire of cancer cell stemness and therapeutic modalities
Rong Yu, Yinhui Hang, Hsiang-i Tsai, Dongqing Wang and Haitao Zhu
Cancer Cell Int, 2024, 24
DOI: 10.1186/s12935-024-03329-x

Small molecule inhibitors from organoid‐based drug screen induce concurrent apoptosis and gasdermin E‐dependent pyroptosis in colorectal cancer
Yuchen Zhang, Zhuoqing Xu, Wenqing Feng, Han Gao, Zifeng Xu, Yiming Miao, Wenchang Li, Fangqian Chen, Zeping Lv, Jianting Huo, Abudumaimaitijiang Tuersun, Wangyi Liu, Yaping Zong, Xiaohui Shen, Jingkun Zhao and Aiguo Lu
Clinical & Translational Med, 2022, 12
DOI: 10.1002/ctm2.812

Re-expression of embryonic stem cell markers in malignant tissue: an observational study in pancreatic cancer
Sashikanta Swain, Sipra Rout, Sarojini Raman, Praveen Kumar Ravi, Sruthy Babu and Pravash Ranjan Mishra
Anat Cell Biol, 2026, 59, 115
DOI: 10.5115/acb.25.310

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer
Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang and Kun Zhang
J Transl Med, 2023, 21
DOI: 10.1186/s12967-023-04120-8

Targeted Cancer Stem Cell Therapeutics: An Update
Naurin Fatima, Mohammad Umar, Subiya Ambreen, Mohammad Shaququzzaman, Mohammad Mumtaz Alam and Ruhi Ali
CTMC, 2025, 25, 842
DOI: 10.2174/0115680266275014240110071351

New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite
Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar and Abeer S. Elsherbiny
Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-01846-3

Discovery of semisynthetic celastrol derivatives exhibiting potent anti-ovarian cancer stem cell activity and STAT3 inhibition
Na Li, Chaobo Li, Juan Zhang, Qian Jiang, Zhaoxue Wang, Shaozhen Nie, Zhenzhen Gao, Guangyao Li, Hao Fang, Shaoda Ren and Xiaojing Li
Chemico-Biological Interactions, 2022, 366, 110172
DOI: 10.1016/j.cbi.2022.110172

Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy
Jingjing Luo, Tongxu Sun, Zhenghui Liu, Yangfan Liu, Junjiang Liu, Shimeng Wang, Xueke Shi and Hongmei Zhou
Int J Oral Sci, 2025, 17
DOI: 10.1038/s41368-025-00380-w

Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma
Jie-Zhuang Huang, Jian-Di Li, Gang Chen and Rong-Quan He
World J Clin Oncol, 2024, 15, 62
DOI: 10.5306/wjco.v15.i1.62

Cancer stem cells: advances in the glucose, lipid and amino acid metabolism
Weina Kong, Yunge Gao, Shuhua Zhao and Hong Yang
Mol Cell Biochem, 2024, 479, 2545
DOI: 10.1007/s11010-023-04861-6

Progress of Cancer Stem Cells in Retinoblastoma
Nan Wang and Jian-Min Ma
CSCR, 2024, 19, 1093
DOI: 10.2174/011574888X252989230921065809

The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia
Xiuying Hu, Tianzhen Hu, Shuyun Cao, Li Jiang, Yan Zhou, Qin Fang and Jishi Wang
Cell Death Dis, 2025, 16
DOI: 10.1038/s41419-025-07927-z

Nanobiotechnology augmented cancer stem cell guided management of cancer: liquid-biopsy, imaging, and treatment
Si Sun, Qiang Yang, Dawei Jiang and Yuan Zhang
J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02432-5

CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition
Zhenya Tan, Ke Pan, Minqiong Sun, Xianzhu Pan, Zhi Yang, Zhiling Chang, Xue Yang, Jicheng Zhu, Li Zhan, Yakun Liu, Xiaofei Li, Keqiong Lin, Lin Chen, Hui Mo, Wei Luo, Chen Kan, Lunxi Duan and Hong Zheng
Cell Death Differ, 2024, 31, 1302
DOI: 10.1038/s41418-024-01360-z

CD44 upregulation in chronic liver disease marks the transition to hepatocellular carcinoma and portends poor prognosis
Rui Dong, Akshaya Srikanth, Umesh Tharehalli, Thomas Seufferlein, Reinhold Schirmbeck and André Lechel
Br J Cancer, 2026, 134, 555
DOI: 10.1038/s41416-025-03284-y

DNA‐Damage‐Response‐Targeting Mitochondria‐Activated Multifunctional Prodrug Strategy for Self‐Defensive Tumor Therapy
Paramesh Jangili, Na Kong, Ji Hyeon Kim, Jun Zhou, Haijun Liu, Xingcai Zhang, Wei Tao and Jong Seung Kim
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202117075

The roles EpCAM plays to enhance the malignancy of gastric cancer
Xuewei Zhao, Ruixia Zhao, Yang Feng, Zuchun Qiu, Xue Bai, Danying Zhang, Yujuan Zhou, Hongming Fang, Niu Liu, Lirong Chen, Chenshuang Jia, Yue Yuan, Xinyao Li, Wei Duan, Guochao Nie and Yingchun Hou
J Cancer Res Clin Oncol, 2023, 149, 8495
DOI: 10.1007/s00432-023-04767-2

Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
Gitika Thakur, Raj Kumar, Saet-Byul Kim, Sang-Yeob Lee, Sung-Lim Lee and Gyu-Jin Rho
Biomedicines, 2021, 9, 178
DOI: 10.3390/biomedicines9020178

Cholesterol metabolism on stem cell fate determination: a frontier horizon
Boyang Xu, Ling Li, Qian Wei, Yuli Wang, He Huang, Tao Pang, Zhijian Wei, Guoqing Zheng and Yue Li
Stem Cell Res Ther, 2025, 16
DOI: 10.1186/s13287-025-04687-7

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells
Hsi-Lung Hsieh, Ming-Chin Yu, Li-Ching Cheng, Ta-Sen Yeh and Ming-Ming Tsai
WJSC, 2022, 14, 76
DOI: 10.4252/wjsc.v14.i1.76

Monitoring inflammation-cancer progression by cell viscosity, polarity and leucine aminopeptidase using multicolor fluorescent probe
Ruixi Li, Jingxuan Guo, Yishan Duan, Xian Liu, Lijuan Gui, Yue Xu, Xiangkai Kong, Yongjun Li, Haiyan Chen and Zhenwei Yuan
Chemical Engineering Journal, 2022, 435, 135043
DOI: 10.1016/j.cej.2022.135043

Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies
Yunhan Tan, Siyuan Qin, Zhe Zhang, Yongen Liu, Li Zhou, Bowen Li, Edouard C. Nice, Yuanyuan Zhang and Jing Jing
MedComm – Oncology, 2025, 4
DOI: 10.1002/mog2.70009

Dendronized hyaluronic acid-docetaxel conjugate as a stimuli-responsive nano-agent for breast cancer therapy
Wenjia Wang, Xiaoqin Zhang, Zhiqian Li, Dayi Pan, Hongyan Zhu, Zhongwei Gu, Jie Chen, Hu Zhang, Qiyong Gong and Kui Luo
Carbohydrate Polymers, 2021, 267, 118160
DOI: 10.1016/j.carbpol.2021.118160

Sniping Cancer Stem Cells with Nanomaterials
Wen-Da Wang, Yan-Yu Guo, Zhong-Lu Yang, Guang-Liang Su and Zhi-Jun Sun
ACS Nano, 2023, 17, 23262
DOI: 10.1021/acsnano.3c07828

Plant-mediated synthesis of biocompatible Fe3O4 nanoparticles for magnetic hyperthermia therapy: A preclinical study in pharmaceutical nanotechnology
A.B. Pandhare, S.V. Mulik, A.S. Patil, D. Sohn, N.B. Birajdar, V.M. Khot, Moonis Ali Khan, A. Manikandan, Lalitha Gnanasekaran, D.S. Vijayan, S. Santhoshkumar, B.E. Keshta, S.D. Delekar and R.P. Patil
Developmental Biology, 2026, 530, 119
DOI: 10.1016/j.ydbio.2025.11.009

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao and Jing Cai
Advanced Science, 2026, 13
DOI: 10.1002/advs.202521279

Detection of atherosclerosis-associated HOCl using a mitochondria-targeted fluorescent probe
Bingya Wang, Fengying Yuan, Shan Wang, Ran Duan, Wen Xiu Ren and Ji-Ting Hou
Sensors and Actuators B: Chemical, 2021, 348, 130695
DOI: 10.1016/j.snb.2021.130695

Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection
Xutong Qiu, Yi Li and Zhuoyuan Zhang
Cell Oncol., 2023, 46, 847
DOI: 10.1007/s13402-023-00801-0

Supramolecular Assembly Based on Sulfato-β-cyclodextrin for Hypoxia Cell Imaging
Hui-Juan Wang, Heng-Yi Zhang, Cong Zhang, Bing Zhang, Xianyin Dai, Xiufang Xu and Yu Liu
ACS Appl. Polym. Mater., 2022, 4, 2935
DOI: 10.1021/acsapm.2c00228

The symbiotic axis between the acidic tumor microenvironment and cancer stem cells: a driver of malignancy and therapeutic resistance
Zhengyu Wang, Hanghang Yuan, Mei Liu, Jupeng Yuan and Dawei Chen
Front. Oncol., 2026, 16
DOI: 10.3389/fonc.2026.1804379

Cancer Stem Cell (CSC) Inhibitors in Oncology—A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives
Prashant S. Kharkar
J. Med. Chem., 2020, 63, 15279
DOI: 10.1021/acs.jmedchem.0c01336

The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status
Margarita Pustovalova, Lina Alhaddad, Taisia Blokhina, Nadezhda Smetanina, Anna Chigasova, Roman Chuprov-Netochin, Petr Eremin, Ilmira Gilmutdinova, Andreyan N. Osipov and Sergey Leonov
IJMS, 2021, 22, 2369
DOI: 10.3390/ijms22052369

Modulatory effects of cancer stem cell-derived extracellular vesicles on the tumor immune microenvironment
Xinyu Li, Cuilian Zhang, Wei Yue and Yuening Jiang
Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1362120

Plasma-derived extracellular matrix for xenofree and cost-effective organoid modeling for hepatocellular carcinoma
Azza M. El-Derby, Mennatallah A. Khedr, Nehal I. Ghoneim, Mahmoud M. Gabr, Sherry M. Khater and Nagwa El-Badri
J Transl Med, 2024, 22
DOI: 10.1186/s12967-024-05230-7

Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma
Xiaotian He, Yiyang Ma, Yingsheng Wen, Rusi Zhang, Dechang Zhao, Gongming Wang, Weidong Wang, Zirui Huang, Guangran Guo, Xuewen Zhang, Huayue Lin and Lanjun Zhang
Bioactive Materials, 2024, 36, 238
DOI: 10.1016/j.bioactmat.2024.02.026

The Great Escape: The Power of Cancer Stem Cells to Evade Programmed Cell Death
Vanessa Castelli, Antonio Giordano, Elisabetta Benedetti, Francesco Giansanti, Massimiliano Quintiliani, Annamaria Cimini and Michele d’Angelo
Cancers, 2021, 13, 328
DOI: 10.3390/cancers13020328

Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy
Jinggong Liu, Wenying Li, Yongpeng Lin, Yongjun Peng, Meixiao Zhan, Haoqiang Lai, Yanzhou Chang, Yongjin Li, Ka-hing Wong, Bolai Chen and Tianfeng Chen
NPG Asia Mater, 2023, 15
DOI: 10.1038/s41427-023-00473-0

Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer
Yuanjiang Wang, Zhaodan Lv, Feihong Chen, Xing Wang and Shaohua Gou
J. Med. Chem., 2021, 64, 12877
DOI: 10.1021/acs.jmedchem.1c01013

CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells
Ruinan Zhao, Xiangyu Guo, Guohao Zhang, Sen Liu, Ranran Ma, Mengqi Wang, Shiming Chen, Wenjie Zhu, Yuan Liu, Peng Gao and Haiting Liu
Cell Death Dis, 2024, 15
DOI: 10.1038/s41419-024-06673-y

Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
Xu Yang, Li Deng, Xianhong Diao, Siyuan Yang, Li Zou, Qin Yang, Jian Li, Jianyun Nie, Lina Zhao and Baowei Jiao
iScience, 2023, 26, 108218
DOI: 10.1016/j.isci.2023.108218

A Small Molecule Strategy for Targeting Cancer Stem Cells in Hypoxic Microenvironments and Preventing Tumorigenesis
Ji Hyeon Kim, Peter Verwilst, Miae Won, Junhyoung Lee, Jonathan L. Sessler, Jiyou Han and Jong Seung Kim
J. Am. Chem. Soc., 2021, 143, 14115
DOI: 10.1021/jacs.1c03875

Microfluidic systems for modeling digestive cancer: a review of recent progress
ZahraSadat Razavi, Madjid Soltani, Hamidreza Pazoki-Toroudi and Mahsa Dabagh
Biomed. Phys. Eng. Express, 2024, 10, 052002
DOI: 10.1088/2057-1976/ad6f15

MiR-21-5p Modulates Cisplatin-Resistance of CD44+ Gastric Cancer Stem Cells Through Regulating the TGF-β2/SMAD Signaling Pathway
Xinyang Nie, Jian Liu, Daohan Wang, Chuan Li, Yuxin Teng, Zhufeng Li, Yangpu Jia, Peiyao Wang, Jingyu Deng, Weidong Li and Li Lu
IJGM, 2024, Volume 17, 4579
DOI: 10.2147/IJGM.S476647

Dual-Targeting CSC Therapy: Acid-Responsive Cisplatin/CaCO3@siRNA Nanoplatform Overcomes HCC Chemoresistance
Fei Wang, Ming Lin, Yong Liu, Han Wang, Bin Li, Tan Yang and Weijie Li
Pharmaceuticals, 2025, 19, 22
DOI: 10.3390/ph19010022

Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance
Leiguang Ye, Jinying Zhu, Xiaoman Wang, Nianhan Chen, Ying Sun, Xuemei Zeng, Shijian Liu and Shuangqian Yan
J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03796-y

Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer
Mengqing Chen, Lin Huang, Mengna Zhu, Jing Cai, Feiquan Ying, Lin Liu, Wenhan Li, Si Sun and Yiping Wen
Cancer Immunol Immunother, 2025, 74
DOI: 10.1007/s00262-025-04215-9

TRIM family contribute to tumorigenesis, cancer development, and drug resistance
Ning Huang, Xiaolin Sun, Peng Li, Xin liu, Xuemei Zhang, Qian Chen and Hong Xin
Exp Hematol Oncol, 2022, 11
DOI: 10.1186/s40164-022-00322-w

Targeting cancer stem cell pathways for lung cancer therapy
Mingxin Liu, Hong Wu and Chuan Xu
Current Opinion in Oncology, 2023, 35, 78
DOI: 10.1097/CCO.0000000000000912

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production
Bei-Bei Zhang, Jun-gang Liu, Xian-Yu Bai, Yuan-Jiao Huang, Ning Xu, Tao Ren and Songwen Tan
Bioinorganic Chemistry and Applications, 2021, 2021, 1
DOI: 10.1155/2021/4763944

Association between lncRNAs with stem cells in cancer; a particular focus on lncRNA-CSCs axis in cancer immunopathogenesis
Raed Obaid Saleh, Abdullah M. Shbeer, Raghu Jetti, Ibrahim Ahmed Robadi, Ahmed Hjazi, Anaheed Hussein Kareem, Maha Noori Shakir, Mohammed Qasim Alasheqi, Ahmed Alawadi and Ali Haslany
International Immunopharmacology, 2024, 136, 112306
DOI: 10.1016/j.intimp.2024.112306

Quantum Biotechnology
Nicolas P. Mauranyapin, Alex Terrasson and Warwick P. Bowen
Adv Quantum Tech, 2022, 5
DOI: 10.1002/qute.202100139

Hyperbaric oxygen regulates tumor microenvironment and boosts commercialized nanomedicine delivery for potent eradication of cancer stem-like cells
Xin Liu, Ningbing Ye, Chen Xiao, Xiaoxian Wang, Shiyou Li, Yihan Deng, Xiaoquan Yang, Zifu Li and Xiangliang Yang
Nano Today, 2021, 40, 101248
DOI: 10.1016/j.nantod.2021.101248

Development of a NIR fluorescent probe for the detection of intracellular cysteine and glutathione and the monitoring of the drug resistance
Xinmiao Lu, Muyu Wu, Siwen Wang, Jingcan Qin and Peiyong Li
Talanta, 2021, 235, 122771
DOI: 10.1016/j.talanta.2021.122771

Cannot Target What Cannot Be Seen: Molecular Imaging of Cancer Stem Cells
Loredana G. Marcu, Leyla Moghaddasi and Eva Bezak
IJMS, 2023, 24, 1524
DOI: 10.3390/ijms24021524

Hypoxia differently regulates the proportion of ALDHhi cells in lung squamous carcinoma H520 and adenocarcinoma A549 cells via the Wnt/β‐catenin pathway
Ni Liu, Qi Zheng, Yuqing Zhang, Huimin Wang, Zhihui Zhang, Long He, Chenxi Wei, Handai Xia, Yanguo Liu and Xiuwen Wang
Thoracic Cancer, 2024, 15, 1419
DOI: 10.1111/1759-7714.15328

Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
Ganping Wang, Ming Zhang, Maosheng Cheng, Xiaochen Wang, Kang Li, Jianwen Chen, Zhi Chen, Shuang Chen, Jie Chen, Gan Xiong, Xiuyun Xu, Cheng Wang and Demeng Chen
Cancer Letters, 2021, 507, 55
DOI: 10.1016/j.canlet.2021.03.009

Liver extracellular matrix hydrogel-based three-dimensional culture system of HepG2 cells to enhance cancer stem cell properties
Lei Chen, Huijing Ma, Kaiming Li, Xinqiang Song and Xiansi Zeng
Materials Science and Engineering: C, 2021, 126, 112119
DOI: 10.1016/j.msec.2021.112119

A Bright Horizon of Intelligent Targeted-cancer Therapy: Nanoparticles Against Breast Cancer Stem Cells
Ahmad Vaez, Milad Abbasi, Leili Shabani, Esmat Azizipour, Mostafa Shafiee, Mohammad Ali Zare, Omid Rahbar, Arezo Azari, Ali Mohammad Amani and Ali Golchin
CSCR, 2023, 18, 787
DOI: 10.2174/1574888X17666221004105330

A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis
Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu and He Lian
Chemical Engineering Journal, 2023, 468, 143730
DOI: 10.1016/j.cej.2023.143730

Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by attenuating the malignancy of cancer stem cells via the gut microbiota-bile acid-FXR axis
Ye Zhang, Meng Shen, Jianaer· Baokan, Liting Xu, Mingxin Ni, Junyan Jin, Weixing Shen, Dongdong Sun, Liu Li, Yueyang Lai, Qiuying Yan, Chengtao Yu, Jiani Tan, Changliang Xu, Lihuiping Tao, Minmin Fan and Haibo Cheng
Phytomedicine, 2025, 148, 157366
DOI: 10.1016/j.phymed.2025.157366

Preoperative CD44v6-positive extracellular vesicles as a prognostic biomarker in pancreatic ductal adenocarcinoma
Yosuke Uematsu, Sachiko Matsuda, Minoru Kitago, Sho Uemura, Gaku Shimane, Yutaka Nakano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Yohei Masugi, Ryo Takemura and Yuko Kitagawa
J Gastroenterol, 2026, 61, 345
DOI: 10.1007/s00535-026-02343-2