Issue 30, 2024

Microfluidic-based cardiovascular systems for advanced study of atherosclerosis

Abstract

Atherosclerosis (AS) is a significant global health concern due to its high morbidity and mortality rates. Extensive efforts have been made to replicate the cardiovascular system and explore the pathogenesis, diagnosis, and treatment of AS. Microfluidics has emerged as a valuable technology for modeling the cardiovascular system and studying AS. Here a brief review of the advances of microfluidic-based cardiovascular systems for AS research is presented. The critical pathogenetic mechanisms of AS investigated by microfluidic-based cardiovascular systems are categorized and reviewed, with a detailed summary of accurate diagnostic methods for detecting biomarkers using microfluidics represented. Furthermore, the review covers the evaluation and screening of AS drugs assisted by microfluidic systems, along with the fabrication of novel drug delivery carriers. Finally, the challenges and future prospects for advancing microfluidic-based cardiovascular systems in AS research are discussed and proposed, particularly regarding new opportunities in multi-disciplinary fundamental research and therapeutic applications for a broader range of disease treatments.

Graphical abstract: Microfluidic-based cardiovascular systems for advanced study of atherosclerosis

Supplementary files

Article information

Article type
Review Article
Submitted
28 رمضان 1445
Accepted
18 ذو الحجة 1445
First published
25 ذو الحجة 1445

J. Mater. Chem. B, 2024,12, 7225-7245

Microfluidic-based cardiovascular systems for advanced study of atherosclerosis

H. Zheng, L. Tai, C. Xu, W. Wang, Q. Ma and W. Sun, J. Mater. Chem. B, 2024, 12, 7225 DOI: 10.1039/D4TB00756E

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