Issue 63, 2024

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

Abstract

This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.

Graphical abstract: Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
15 ذو القعدة 1445
Accepted
02 محرم 1446
First published
03 محرم 1446

Chem. Commun., 2024,60, 8248-8251

Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy

L. Zhang, M. He, X. Xia, Z. Ma, C. Lv, R. Wang, W. Liu, J. Fan, X. Peng and W. Sun, Chem. Commun., 2024, 60, 8248 DOI: 10.1039/D4CC02391A

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