Issue 23, 2023

Breast tumor-on-chip: from the tumor microenvironment to medical applications

Abstract

With the development of microfluidic technology, tumor-on-chip models have gradually become a new tool for the study of breast cancer because they can simulate more key factors of the tumor microenvironment compared with traditional models in vitro. Here, we review up-to-date advancements in breast tumor-on-chip models. We summarize and analyze the breast tumor microenvironment (TME), preclinical breast cancer models for TME simulation, fabrication methods of tumor-on-chip models, tumor-on-chip models for TME reconstruction, and applications of breast tumor-on-chip models and provide a perspective on breast tumor-on-chip models. This review will contribute to the construction and design of microenvironments for breast tumor-on-chip models, even the development of the pharmaceutical field, personalized/precision therapy, and clinical medicine.

Graphical abstract: Breast tumor-on-chip: from the tumor microenvironment to medical applications

Article information

Article type
Critical Review
Submitted
11 محرم 1445
Accepted
11 ربيع الأول 1445
First published
13 ربيع الأول 1445

Analyst, 2023,148, 5822-5842

Breast tumor-on-chip: from the tumor microenvironment to medical applications

Y. Liu, R. Liu, H. Liu, T. Lyu, K. Chen, K. Jin and Y. Tian, Analyst, 2023, 148, 5822 DOI: 10.1039/D3AN01295F

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