Issue 9, 2022

Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

Abstract

The first C–H trifluoroethylamination of heteroarenes with previously unknown N-trifluoroethyl hydroxylamine reagents was achieved under photoredox catalyzed conditions. In the presence of an iridium(III) photoredox catalyst, a variety of heteroarenes, such as indoles, benzofurans, and benzothiophenes, were smoothly converted to the trifluoroethylaminated products in moderate to high yields and with excellent regioselectivity.

Graphical abstract: Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

Supplementary files

Article information

Article type
Communication
Submitted
24 ربيع الثاني 1443
Accepted
16 جمادى الأولى 1443
First published
02 جمادى الثانية 1443

Chem. Commun., 2022,58, 1346-1349

Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

J. Wang, S. Liu, Y. Huang, X. Xu and F. Qing, Chem. Commun., 2022, 58, 1346 DOI: 10.1039/D1CC06688A

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