Issue 15, 2022

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Abstract

The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use of antibiotics in feed. Therefore, it is an urgent need to develop alternatives to antibiotics to control infectious diseases in feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent and broad-spectrum activity against common pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and do not induce bacteria to develop resistance or cross-resistance to antibiotics. The optimal peptide polymer demonstrates strong in vivo therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance.

Graphical abstract: Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

Supplementary files

Article information

Article type
Paper
Submitted
29 رمضان 1443
Accepted
25 شوال 1443
First published
02 ذو القعدة 1443

Biomater. Sci., 2022,10, 4193-4207

Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

P. Ma, Y. Wu, W. Jiang, N. Shao, M. Zhou, Y. Chen, J. Xie, Z. Qiao and R. Liu, Biomater. Sci., 2022, 10, 4193 DOI: 10.1039/D2BM00672C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements