Issue 24, 2021

Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines

Abstract

A series of chiral ferrocene-backbone phosphines-spiro phosphonamidite ligands was developed for ruthenium-catalyzed enantioselective access to a broad range of β-amino alcohols from 1,2-diols and amines via the borrowing-hydrogen prciniple. Up to >99% ee with a broad substrate scope was attained. Late-stage functionalization of drugs and natural products were realized by means of this route. Data from density-functional-theory studies were in good agreement with experimental results.

Graphical abstract: Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines

Supplementary files

Article information

Article type
Research Article
Submitted
17 صفر 1443
Accepted
21 ربيع الأول 1443
First published
28 ربيع الأول 1443

Org. Chem. Front., 2021,8, 6830-6836

Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines

X. Yi, Y. Chen, A. Huang, D. Song, J. He, F. Ling and W. Zhong, Org. Chem. Front., 2021, 8, 6830 DOI: 10.1039/D1QO01443A

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