Issue 98, 2021

Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Abstract

An iron-catalysed C–H functionalisation of simple monosubstituted allenes for the synthesis of 1-tetrahydroisoquinolinyl 1,1-disubstituted allenes is reported. This transformation represents the first example of a direct conversion of allenic C–H bonds to C–C bonds through cross dehydrogenative coupling. The optimized protocol features broad scope and employs mild, functional group tolerant conditions.

Graphical abstract: Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Supplementary files

Article information

Article type
Communication
Submitted
16 ربيع الأول 1443
Accepted
13 ربيع الثاني 1443
First published
19 ربيع الثاني 1443

Chem. Commun., 2021,57, 13329-13332

Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp2)–H functionalisation

Y. Xia, N. W. Wade, P. N. Palermo, Y. Wang and Y. Wang, Chem. Commun., 2021, 57, 13329 DOI: 10.1039/D1CC05949A

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