Issue 7, 2019

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Abstract

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. By this method, a variety of chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities. This work not only provides a new pathway for the synthesis of chiral oxazolines, but also expands the library of chiral trifluoromethylthiolated molecules.

Graphical abstract: Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Supplementary files

Article information

Article type
Communication
Submitted
08 صفر 1440
Accepted
27 صفر 1440
First published
27 صفر 1440

Org. Biomol. Chem., 2019,17, 1763-1766

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

T. Qin, Q. Jiang, J. Ji, J. Luo and X. Zhao, Org. Biomol. Chem., 2019, 17, 1763 DOI: 10.1039/C8OB02575D

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