Issue 21, 2019

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Abstract

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C–C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.

Graphical abstract: Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Supplementary files

Article information

Article type
Communication
Submitted
13 ربيع الثاني 1440
Accepted
05 رجب 1440
First published
13 رجب 1440

Dalton Trans., 2019,48, 7094-7099

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

J. Rana, V. Gupta and E. Balaraman, Dalton Trans., 2019, 48, 7094 DOI: 10.1039/C8DT05020A

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