Issue 13, 2019

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Graphical abstract: High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Supplementary files

Article information

Article type
Paper
Submitted
03 صفر 1440
Accepted
19 ربيع الأول 1440
First published
19 ربيع الأول 1440

CrystEngComm, 2019,21, 2135-2143

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

I. Torres-Moya, B. Saikia, P. Prieto, J. R. Carrillo and J. W. Steed, CrystEngComm, 2019, 21, 2135 DOI: 10.1039/C8CE01742E

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