Issue 40, 2018

Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Abstract

Cp*Co(III)-catalysed selective alkylation of directed C–H bonds of arenes and heteroarenes has been accomplished employing donor–acceptor carbenes, derived from α-diazocarbonyl compounds. The developed method allows ready access to various substituted α-(hetero)aryl-α-arylacetic acid derivatives in good to excellent yields. Synthetic utility was also shown through the synthesis of a substituted indole derivative, an anticancer agent.

Graphical abstract: Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
17 ذو الحجة 1439
Accepted
11 محرم 1440
First published
11 محرم 1440

Org. Biomol. Chem., 2018,16, 7346-7350

Cp*Co(III)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

J. Ghorai, M. Chaitanya and P. Anbarasan, Org. Biomol. Chem., 2018, 16, 7346 DOI: 10.1039/C8OB02111B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements