Issue 39, 2018

Iron-catalysed carbene-transfer reactions of diazo acetonitrile

Abstract

A continuous-flow protocol for the synthesis of diazo acetonitrile was developed. It was further applied in iron-catalysed insertion reactions of diazo acetonitrile into N–H and S–H bonds to yield valuable α-substituted acetonitrile, including gram-scale synthesis.

Graphical abstract: Iron-catalysed carbene-transfer reactions of diazo acetonitrile

Supplementary files

Article information

Article type
Communication
Submitted
04 ذو الحجة 1439
Accepted
10 محرم 1440
First published
10 محرم 1440

Org. Biomol. Chem., 2018,16, 7129-7133

Iron-catalysed carbene-transfer reactions of diazo acetonitrile

C. Empel, K. J. Hock and R. M. Koenigs, Org. Biomol. Chem., 2018, 16, 7129 DOI: 10.1039/C8OB01991F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements