Issue 50, 2018

Bead-based screening in chemical biology and drug discovery

Abstract

High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.

Graphical abstract: Bead-based screening in chemical biology and drug discovery

Article information

Article type
Feature Article
Submitted
10 رجب 1439
Accepted
15 رمضان 1439
First published
15 رمضان 1439

Chem. Commun., 2018,54, 6759-6771

Bead-based screening in chemical biology and drug discovery

V. V. Komnatnyy, T. E. Nielsen and K. Qvortrup, Chem. Commun., 2018, 54, 6759 DOI: 10.1039/C8CC02486C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements