Issue 6, 2018

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

Abstract

A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.

Graphical abstract: Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

Supplementary files

Article information

Article type
Communication
Submitted
10 صفر 1439
Accepted
03 ربيع الثاني 1439
First published
03 ربيع الثاني 1439

Chem. Commun., 2018,54, 658-661

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

D. Bouzada, I. Salvadó, G. Barka, G. Rama, J. Martínez-Costas, R. Lorca, Á. Somoza, M. Melle-Franco, M. E. Vázquez and M. Vázquez López, Chem. Commun., 2018, 54, 658 DOI: 10.1039/C7CC08286J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements