[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

Abstract

Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl₃(BnMe₂-tacn)] via treatment with 2.99 mol. equiv. of [¹⁹F]KF doped with cyclotron-produced [¹⁸F]F⁻ target water, with heating to 80–100 °C for 1 h, gives up to 24% ¹⁸F incorporation. SPE purification of the [Al¹⁹F₂¹⁸F(BnMe₂-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).