Issue 42, 2016

Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Abstract

An efficient copper-catalyzed oxidative decarboxylative amination of arylacetic acids with 2-aminobenzoketones and ammonium acetate under an oxygen atmosphere was first developed. This reaction represents a novel avenue for 2-arylquinazolines in good to excellent yields via multiple C–N bond formations. This protocol features inexpensive copper as the catalyst, molecular oxygen as the sole oxidant, H2O and CO2 as wastes, and a broad substrate scope.

Graphical abstract: Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Supplementary files

Article information

Article type
Paper
Submitted
07 جمادى الأولى 1437
Accepted
26 جمادى الثانية 1437
First published
27 جمادى الثانية 1437

RSC Adv., 2016,6, 36192-36197

Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines

Y. Yan, M. Shi, B. Niu, X. Meng, C. Zhu, G. Liu, T. Chen and Y. Liu, RSC Adv., 2016, 6, 36192 DOI: 10.1039/C6RA04195G

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