Issue 30, 2015

Design of hybrid nanovehicles for remotely triggered drug release: an overview

Abstract

In the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed.

Graphical abstract: Design of hybrid nanovehicles for remotely triggered drug release: an overview

Article information

Article type
Review Article
Submitted
21 جمادى الثانية 1436
Accepted
17 شعبان 1436
First published
28 شعبان 1436

J. Mater. Chem. B, 2015,3, 6117-6147

Author version available

Design of hybrid nanovehicles for remotely triggered drug release: an overview

J. Liu, C. Detrembleur, S. Mornet, C. Jérôme and E. Duguet, J. Mater. Chem. B, 2015, 3, 6117 DOI: 10.1039/C5TB00664C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements