The aqueous medium-dimethylsulfoxide conundrum in biological studies

Saeedeh Negin; Michael R. Gokel; Mohit B. Patel; Sergey L. Sedinkin; David C. Osborn; George W. Gokel

doi:10.1039/C4RA15217D

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The aqueous medium-dimethylsulfoxide conundrum in biological studies

Saeedeh Negin,^ab Michael R. Gokel,^a Mohit B. Patel,^bc Sergey L. Sedinkin,^ab David C. Osborn^a and George W. Gokel*^abc

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* Corresponding authors

^a Center for Nanoscience, University of Missouri-St. Louis, St. Louis, Missouri, USA
E-mail: gokelg@umsl.edu
Fax: +1-314-516-5342
Tel: +1-314-516-5321

^b Dept. of Chemistry, University of Missouri-St. Louis, St. Louis, Missouri, USA

^c Department of Biology, University of Missouri-St. Louis, St. Louis, Missouri, USA

Abstract

A series of straight and branched chain pyrogallol[4]arenes was studied and found to be essentially nontoxic to two strains of E. coli. An apparent enhancement of potency observed for kanamycin against E. coli was found to be due to the presence of DMSO in the growth media. Quantitative studies are presented that assay the effect of DMSO concentration on the apparent potency of kanamycin against E. coli.

This article is part of the themed collection: Supramolecular Chemistry in Water

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Article information

DOI: https://doi.org/10.1039/C4RA15217D
Article type: Paper
Submitted: 03 صفر 1436
Accepted: 23 صفر 1436
First published: 23 صفر 1436

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RSC Adv., 2015,5, 8088-8093

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The aqueous medium-dimethylsulfoxide conundrum in biological studies

S. Negin, M. R. Gokel, M. B. Patel, S. L. Sedinkin, D. C. Osborn and G. W. Gokel, RSC Adv., 2015, 5, 8088 DOI: 10.1039/C4RA15217D

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The aqueous medium-dimethylsulfoxide conundrum in biological studies

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