Issue 1, 2015

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Abstract

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.

Graphical abstract: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Article information

Article type
Feature Article
Submitted
20 شوال 1435
Accepted
09 ذو القعدة 1435
First published
10 ذو القعدة 1435

Chem. Commun., 2015,51, 34-45

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

A. E. Goetz, T. K. Shah and N. K. Garg, Chem. Commun., 2015, 51, 34 DOI: 10.1039/C4CC06445C

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