Issue 7, 2015

Infrared micro-spectroscopy for cyto-pathological classification of esophageal cells

Abstract

We report results from a study utilizing infrared spectral cytopathology (SCP) to detect abnormalities in exfoliated esophageal cells. SCP has been developed over the past decade as an ancillary tool to classical cytopathology. In SCP, the biochemical composition of individual cells is probed by collecting infrared absorption spectra from each individual, unstained cell, and correlating the observed spectral patterns, and the variations therein, against classical diagnostic methods to obtain an objective, machine-based classification of cells. In the past, SCP has been applied to the analysis and classification of cells exfoliated from the cervix and the oral cavity. In these studies, it was established that SCP can distinguish normal and abnormal cell types. Furthermore, SCP can differentiate between truly normal cells, and cells with normal morphology from the vicinity of abnormalities. Thus, SCP may be a valuable tool for the screening of early stages of dysplasia and pre-cancer.

Graphical abstract: Infrared micro-spectroscopy for cyto-pathological classification of esophageal cells

Article information

Article type
Paper
Submitted
23 ذو الحجة 1435
Accepted
26 صفر 1436
First published
26 صفر 1436

Analyst, 2015,140, 2215-2223

Author version available

Infrared micro-spectroscopy for cyto-pathological classification of esophageal cells

D. Townsend, M. Miljković, B. Bird, K. Lenau, O. Old, M. Almond, C. Kendall, G. Lloyd, N. Shepherd, H. Barr, N. Stone and M. Diem, Analyst, 2015, 140, 2215 DOI: 10.1039/C4AN01884B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements