Issue 6, 2010

A graphene-enhanced molecular beacon for homogeneous DNA detection

Abstract

In this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method.

Graphical abstract: A graphene-enhanced molecular beacon for homogeneous DNA detection

Article information

Article type
Paper
Submitted
23 ذو الحجة 1430
Accepted
15 ربيع الأول 1431
First published
27 جمادى الأولى 1431

Nanoscale, 2010,2, 1021-1026

A graphene-enhanced molecular beacon for homogeneous DNA detection

F. Li, Y. Huang, Q. Yang, Z. Zhong, D. Li, L. Wang, S. Song and C. Fan, Nanoscale, 2010, 2, 1021 DOI: 10.1039/B9NR00401G

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