Issue 41, 2009

NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

Abstract

Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.

Graphical abstract: NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

Supplementary files

Article information

Article type
Communication
Submitted
03 رجب 1430
Accepted
23 شعبان 1430
First published
06 رمضان 1430

Chem. Commun., 2009, 6210-6212

NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

M. G. Schrems and A. Pfaltz, Chem. Commun., 2009, 6210 DOI: 10.1039/B912680E

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