Issue 21, 2023

Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

Abstract

A photoredox-catalyzed direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes is described, providing a practical approach for the generation of diverse fluoroalkyl-containing quinoxalin-2(1H)-ones. This methodology exhibits good reaction efficiency, excellent functional group tolerance and extensive structural diversity. In this transformation, difluoromethyl and monofluoroalkyl triphenylphosphonium salts are used as the precursors for providing the corresponding fluoroalkyl radicals via a single electron transfer process under photoredox catalysis.

Graphical abstract: Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
19 محرم 1445
Accepted
30 صفر 1445
First published
30 صفر 1445

Org. Chem. Front., 2023,10, 5375-5382

Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

W. Wang, T. Zhu and J. Wu, Org. Chem. Front., 2023, 10, 5375 DOI: 10.1039/D3QO01247F

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