Solvent-free and catalyst-free direct alkylation of alkenes

Meng-Yao Li; Jiatong Li; Ao Gu; Xiao-Mei Nong; Shuyang Zhai; Zhu-Ying Yue; Chen-Guo Feng; Yingbin Liu; Guo-Qiang Lin

doi:10.1039/D3GC02685J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Solvent-free and catalyst-free direct alkylation of alkenes†‡

Meng-Yao Li,

§^a Jiatong Li,§^a Ao Gu,^a Xiao-Mei Nong,^a Shuyang Zhai,^a Zhu-Ying Yue,^a Chen-Guo Feng,

*^b Yingbin Liu*^a and Guo-Qiang Lin^b

Author affiliations

* Corresponding authors

^a State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
E-mail: laoniulyb@shsmu.edu.cn

^b The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
E-mail: fengcg@shutcm.edu.cn

Abstract

A convenient method for synthesizing aryl-containing trisubstituted alkenes through direct alkylation of alkenes was successfully achieved under solvent-free and catalyst-free conditions. The absence of solvents was found to be crucial in initiating this sequence. Moreover, this protocol stands out due to its minimal waste production and straightforward operation. The radical capture experiment provided evidence for an ionic reaction mechanism.

This article is part of the themed collection: 130th Anniversary of Wuhan University

Download options Please wait...

Supplementary files

Supplementary information PDF (6472K)

Article information

DOI: https://doi.org/10.1039/D3GC02685J
Article type: Communication
Submitted: 04 محرم 1445
Accepted: 24 محرم 1445
First published: 28 محرم 1445

Download Citation

Green Chem., 2023,25, 7073-7078

Permissions

Request permissions

Solvent-free and catalyst-free direct alkylation of alkenes

M. Li, J. Li, A. Gu, X. Nong, S. Zhai, Z. Yue, C. Feng, Y. Liu and G. Lin, Green Chem., 2023, 25, 7073 DOI: 10.1039/D3GC02685J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Green Chemistry

Solvent-free and catalyst-free direct alkylation of alkenes†‡

Abstract

Supplementary files

Article information

Download Citation

Permissions

Solvent-free and catalyst-free direct alkylation of alkenes

Social activity

Search articles by author

Spotlight

Advertisements