Issue 57, 2023

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Abstract

In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

Graphical abstract: Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Supplementary files

Article information

Article type
Communication
Submitted
15 شوال 1444
Accepted
16 ذو القعدة 1444
First published
18 ذو القعدة 1444

Chem. Commun., 2023,59, 8806-8809

Author version available

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Y. Hsu, S. J. Chen, J. Bernal-Chanchavac, B. Sharma, H. Moghimianavval, N. Stephanopoulos and A. P. Liu, Chem. Commun., 2023, 59, 8806 DOI: 10.1039/D3CC02204H

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